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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Research Articles

Recurrent Prostate Cancer Genomic Alterations Predict Response to Brachytherapy Treatment

Jacqueline Fontugne, Daniel Lee, Chiara Cantaloni, Christopher E. Barbieri, Orazio Caffo, Esther Hanspeter, Guido Mazzoleni, Paolo Dalla Palma, Mark A. Rubin, Giovanni Fellin, Juan Miguel Mosquera, Mattia Barbareschi and Francesca Demichelis
Jacqueline Fontugne
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Daniel Lee
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Chiara Cantaloni
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Christopher E. Barbieri
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Orazio Caffo
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Esther Hanspeter
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Guido Mazzoleni
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Paolo Dalla Palma
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Mark A. Rubin
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Giovanni Fellin
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Juan Miguel Mosquera
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Mattia Barbareschi
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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Francesca Demichelis
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
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DOI: 10.1158/1055-9965.EPI-13-1180 Published April 2014
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Article Information

Volume 23, Issue 4, pp. 594-600

DOI 
https://doi.org/10.1158/1055-9965.EPI-13-1180
PubMed 
24515272

Published By 
American Association for Cancer Research
Print ISSN 
1055-9965
Online ISSN 
1538-7755
History 
  • Received November 10, 2013
  • Revision received December 31, 2013
  • Accepted January 15, 2014
  • Published first February 10, 2014.

Article Versions

  • Previous version (February 10, 2014 - 06:35).
  • Previous version (March 18, 2014 - 06:21).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Jacqueline Fontugne1,
  2. Daniel Lee1,2,
  3. Chiara Cantaloni5,
  4. Christopher E. Barbieri1,2,
  5. Orazio Caffo6,
  6. Esther Hanspeter9,
  7. Guido Mazzoleni9,
  8. Paolo Dalla Palma7,
  9. Mark A. Rubin1,2,3,
  10. Giovanni Fellin8,
  11. Juan Miguel Mosquera1,3,
  12. Mattia Barbareschi7, and
  13. Francesca Demichelis4,5
  1. Authors' Affiliations: Departments of 1Pathology and Laboratory Medicine and 2Urology; 3Institute for Precision Medicine; 4Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York; 5Centre for Integrative Biology, University of Trento; Departments of 6Medical Oncology, 7Pathology, and 8Radiotherapy and Medical Physics, Ospedale Santa Chiara, Trento; and 9Department of Surgical Pathology, Central Hospital, Bolzano, Italy
  1. Corresponding Authors:
    Francesca Demichelis, Centre for Integrative Biology, University of Trento, Via Sommarive, 14, 38123 Povo, Trento, Italy. Phone: 39-0461-285305; Fax: 39-0461-283937; E-mail: demichelis{at}science.unitn.it; and Juan Miguel Mosquera, Weill Medical College of Cornell University, NewYork-Presbyterian Hospital, 525 East 68th Street, ST-1015B, New York, NY 10065. Phone: 212-746-2700; Fax: 212-746-8816; E-mail: jmm9018{at}med.cornell.edu
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Cancer Epidemiology Biomarkers & Prevention: 23 (4)
April 2014
Volume 23, Issue 4
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Recurrent Prostate Cancer Genomic Alterations Predict Response to Brachytherapy Treatment
Jacqueline Fontugne, Daniel Lee, Chiara Cantaloni, Christopher E. Barbieri, Orazio Caffo, Esther Hanspeter, Guido Mazzoleni, Paolo Dalla Palma, Mark A. Rubin, Giovanni Fellin, Juan Miguel Mosquera, Mattia Barbareschi and Francesca Demichelis
Cancer Epidemiol Biomarkers Prev April 1 2014 (23) (4) 594-600; DOI: 10.1158/1055-9965.EPI-13-1180

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Recurrent Prostate Cancer Genomic Alterations Predict Response to Brachytherapy Treatment
Jacqueline Fontugne, Daniel Lee, Chiara Cantaloni, Christopher E. Barbieri, Orazio Caffo, Esther Hanspeter, Guido Mazzoleni, Paolo Dalla Palma, Mark A. Rubin, Giovanni Fellin, Juan Miguel Mosquera, Mattia Barbareschi and Francesca Demichelis
Cancer Epidemiol Biomarkers Prev April 1 2014 (23) (4) 594-600; DOI: 10.1158/1055-9965.EPI-13-1180
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