Article Figures & Data
Tables
- Table 1.
Demographic and mtDNA CN characteristics of ATBC, PLCO, and SWHS populations
Cases Controls Study (Ca/Co) Characteristic Mean/N SD/% Mean/N SD/% P valuea ATBC BMI (kg/m2) 25.59 3.49 26.35 3.87 0.045 (227/227) Age 56.67 5.00 58.41 4.79 0.68 Years smoking 38.47 7.11 35.83 9.22 0.005 Ever smoker 227 100 227 100 1 mtDNA CN 134.23 45.27 127.85 36.07 0.26 median, IQR 125.86 (102.04–160.18) 124.79 (100.63–151.51) PLCO BMI (kg/m2) 26.84 4.39 27.43 4.36 0.028 (426/436) Age 64.07 4.95 63.67 4.71 0.22 Years smoking 34.89 15.15 15.57 17.47 <0.0001 Ever smoker 380 89.20 238 54.59 <0.0001 mtDNA CN 128.37 128.26 127.39 59.96 0.079 median, IQR 110 (87–140) 114 (90–145) Sex Male 259 60.80 267 61.24 0.89 Female 167 39.20 169 38.76 Race White 399 93.66 404 92.66 0.81 Black 15 3.52 18 4.13 Other 12 2.82 14 3.21 Center University of Colorado 23 5.40 23 5.28 1 Georgetown University 19 4.46 19 4.36 Pacific Health Research and Education Institute 9 2.11 9 2.06 Henry Ford Health System 66 15.49 63 14.45 University of Minnesota 126 29.58 131 30.05 Washington University 50 11.74 50 11.47 University of Pittsburgh 43 10.09 46 10.55 University of Utah 29 6.81 31 7.11 Marshfield Clinic Research Foundation 45 10.56 47 10.78 University of Alabama Birmingham 16 3.76 17 3.90 SWHS BMI (kg/m2) 24.58 3.45 25.01 3.53 0.16 (221/222) Age 59.22 8.20 59.18 8.35 0.93 Years smoking 2.97 10.67 1.74 8.19 0.23 Ever smoker 17 7.69 11 4.95 0.24 mtDNA CN 191.84 315.45 185.88 268.6 0.82 median, IQR 118 (94–158) 124 (93–162) Abbreviations: Ca, cases; Co, controls; IQR, interquartile range.
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↵aWilcoxon rank-sum test for continuous variables/Pearson χ2 for categorical variables.
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- Table 2.
mtDNA copy number and risk of lung cancer across ATBC, PLCO, and SWHS studies by sex and smoking status
ATBC (Ca 227/Co 227) PLCO (Ca 426/Co 436) SWHS (Ca 221/Co 222) Pooled mtDNA% Ca/Co ORa 95% CI Ca/Co ORa 95% CI Ca/Co ORa 95% CI Ca/Co ORa 95% CI Overall Q1 52/57 1.00 (ref.) 117/107 1 (ref.) 54/56 1.00 (ref.) 223/220 1.00 (ref.) Q2 59/56 1.34 (0.71–2.37) 119/110 0.98 (0.64–1.50) 72/58 1.27 (0.48–1.47) 250/224 1.08 (0.82–1.42) Q3 43/57 1.15 (0.61–2.17) 96/108 0.84 (0.55–1.29) 44/53 0.84 (0.48–1.47) 183/218 0.83 (0.62–1.11) Q4 73/57 2.38 (1.12–5.06) 94/111 0.98 (0.63–1.52) 51/55 0.91 (0.53–1.57) 218/223 1.04 (0.79–1.39) P trend 0.049 P trend 0.74 P trend 0.42 P trend 0.78 Female Q1 — — 32/40 1 (ref.) 54/56 1.00 (ref.) 86/96 1.00 (ref.) Q2 — — 38/41 1.51 (0.74–3.11) 72/58 1.27 (0.48–1.47) 110/99 1.34 (0.89–2.02) Q3 — — 41/44 1.47 (0.73–2.98) 44/53 0.84 (0.48–1.47) 85/97 1.03 (0.67–1.58) Q4 — — 56/44 2.12 (1.07–4.22) 51/55 0.91 (0.53–1.57) 107/99 1.24 (0.82–1.89) P trend 0.043 P trend 0.42 P trend 0.59 Male Q1 52/57 1.00 (ref.) 85/67 1 (ref.) — — 137/125 1.00 (ref.) Q2 59/56 1.34 (0.71–2.37) 81/69 0.76 (0.44–1.28) — — 140/125 0.89 (0.61–1.29) Q3 43/57 1.15 (0.61–2.17) 55/64 0.59 (0.34–1.05) — — 98/121 0.69 (0.46–1.02) Q4 73/57 2.38 (1.12–5.06) 38/67 0.55 (0.29–0.99) — — 111/124 0.92 (0.62–1.35) P trend 0.049 P trend 0.028 P trend 0.39 Never smoker Q1 — — 9/51 1 (ref.) 52/53 1.00 (ref.) 61/104 1.00 (ref.) Q2 — — 11/51 1.35 (0.49–3.72) 66/58 1.15 (0.68–1.94) 77/109 1.17 (0.74–1.85) Q3 — — 12/42 1.23 (0.43–3.57) 40/51 0.79 (0.44–1.40) 51/93 0.86 (0.52–1.41) Q4 — — 14/54 1.49 (0.55–4.08) 46/49 0.94 (0.54–1.65) 60/103 1.03 (0.64–1.68) P trend 0.49 P trend 0.54 P trend 0.79 Ever smoker Q1 52/57 1.00 (ref.) 108/56 1 (ref.) 2/3 1.00 (ref.) 162/116 1.00 (ref.) Q2 59/56 1.34 (0.71–2.37) 108/59 0.91 (0.56–1.47) 6/0 — — 173/115 1.03 (0.73–1.47) Q3 43/57 1.15 (0.61–2.17) 84/66 0.72 (0.44–1.17) 4/2 4.33 (0.24–79.49) 132/125 0.78 (0.54–1.12) Q4 73/57 2.38 (1.12–5.06) 80/57 0.84 (0.50–1.39) 5/6 1.05 (0.087–12.81) 158/120 1.05 (0.73–1.49) P trend 0.049 P trend 0.33 P trend 0.46 P trend 0.81 Male smoker Q1 52/57 1.00 (ref.) 78/38 1 (ref.) — — 130/95 1 (ref.) Q2 59/56 1.34 (0.71–2.37) 78/40 0.8 (0.45–1.45) — — 137/96 0.94 (0.63–1.39) Q3 43/57 1.15 (0.61–2.17) 53/45 0.58 (0.32–1.06) — — 96/102 0.69 (0.46–1.03) Q4 73/57 2.38 (1.12–5.06) 33/37 0.50 (0.25–0.98) — — 106/94 0.95 (0.63–1.43) P trend 0.049 P trend 0.021 P trend 0.45 NOTE: %Quartiles: ATBC: <100.6, ≥100.6–124.8, ≥124.8–151.5, ≥151.5; PLCO: <90, ≥90–114, ≥114–145, ≥145; SWHS: <93, ≥93–124, ≥124–162, ≥162; Median: ATBC: ≤124.8; PLCO: ≤114, SWHS: <124.
Abbreviations: Ca, cases; Co, controls; Q1–Q4, quartiles.
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↵aAdjusted for age, BMI, pack-years, race, sex, date of enrollment, center (if applicable), and study.
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