Article Figures & Data
Tables
- Table 1.
Vigorous exercise at baseline according to baseline characteristics (age-standardized)
H/wk Characteristics <1 1–4 ≥5 Number of women 22,760 14,638 5,399 Age, % 30–39 37 51 54 40–49 37 34 33 50–59 18 12 10 ≥60 8 3 3 BMI, mean 29.4 27.6 26.7 ≥16 years of education, % 40 51 48 Age at menarche ≤ 11, % 28 27 26 Nulliparous, % 24 29 30 First birth before age 20, % 27 22 25 Recent oral contraceptive user, % 32 33 33 Female hormone user, % 19 20 19 Premenopausal, % 70 71 71 Age at menopause < 45, % 21 20 20 Family history of breast cancer, % 7 7 8 Cigarette smoking, % Never smoked 58 60 58 <20 pack years 30 31 31 ≥20 pack years 10 8 8 Alcohol consumption, % Never drank 58 56 55 <7 drinks/d 35 37 36 ≥7 drinks/d 6 6 8 Vegetable/fruit pattern, top quintile, % 15 25 33 Meat/fried foods pattern, top quintile, % 23 16 13 Any walking for exercise at baseline <1 h/wk 57 27 20 ≥5 h/wk 8 13 41 Brisk walking for exercise at baseline <1 h/wk 87 71 64 ≥5 h/wk 3 6 19 Vigorous exercise at age 30 ≥5 h/wk 9 19 60 Vigorous exercise at age 21 ≥5 h/wk 18 32 53 Vigorous exercise in high school ≥5 h/wk 28 45 62 Sitting watching TV at baseline <1 h/d 10 13 13 ≥5 h/d 17 11 15 Sitting at work at baseline <1 h/d 20 16 18 ≥5 h/d 48 50 50 - Table 2.
Vigorous exercise at baseline in relation to incidence of breast cancer overall and ER+ and ER− breast cancer
All breast cancer ER+ breast cancer ER− breast cancer h/wk Cases Person-years IRRa (95% CI) Cases IRR (95% CI) Cases IRR (95% CI) <1 773 313,900 1.00 (Ref.) 382 1.00 (Ref.) 228 1.00 (Ref.) 1 117 62,939 0.85 (0.70–1.03) 59 0.86 (0.66–1.14) 35 0.83 (0.58–1.18) 2 149 67,081 0.99 (0.83–1.19) 76 1.00 (0.78–1.29) 45 1.00 (0.72–1.38) 3–4 159 77,243 0.94 (0.79–1.12) 84 0.98 (0.77–1.25) 45 0.88 (0.63–1.22) 5–6 69 35,793 0.89 (0.69–1.14) 36 0.92 (0.65–1.30) 23 0.97 (0.63–1.50) ≥7 63 39,593 0.74 (0.57–0.96) 32 0.75 (0.52–1.09) 22 0.85 (0.55–1.33) Ptrend = 0.05 Ptrend = 0.28 Ptrend = 0.43 -
↵aIRRs adjusted for age (single year), time period (questionnaire cycle), years of education (≤12, 13–15, 16, ≥17), parity (0, 1, 2, ≥3), vegetable/fruit dietary pattern (quintiles), and meat/fried foods dietary pattern (quintiles)
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- Table 3.
Brisk walking at baseline in relation to breast cancer overall, ER+, and ER− breast cancer
All breast cancer ER+ breast cancer ER− breast cancer h/wk Cases Person-years IRRa (95% CI) Cases IRR (95% CI) Cases IRR (95% CI) <1 1,086 470,638 1.00 (Ref.) 544 1.00 (Ref.) 310 1.00 (Ref.) 1 67 31,643 0.96 (0.75–1.22) 36 1.02 (0.72–1.43) 23 1.10 (0.72–1.68) 2 59 32,662 0.79 (0.61–1.03) 34 0.88 (0.62–1.25) 14 0.63 (0.37–1.08) 3–4 78 37,884 0.88 (0.69–1.11) 36 0.77 (0.55–1.09) 30 1.17 (0.79–1.71) 5–6 40 20,299 0.84 (0.61–1.16) 20 0.80 (0.51–1.27) 16 1.14 (0.68–1.90) 7+ 29 17,057 0.77 (0.53–1.13) 16 0.83 (0.50–1.38) 10 0.88 (0.46–1.68) Ptrend = 0.02 Ptrend = 0.08 Ptrend = 0.98 NOTE: Walking defined as brisk based on fairly brisk or brisk pace reported on the 2003 or 2005 questionnaire
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↵aIRRs adjusted for age (single year), time period (questionnaire cycle), BMI (<25, 25–29, ≥30 kg/m2), years of education (≤12, 13–15, 16, ≥17), parity (0, 1, 2, ≥3), vegetable/fruit dietary pattern (quintiles), meat/fried foods dietary pattern (quintiles), and vigorous exercise (<1, 1–4, ≥5 h/wk).
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- Table 4.
Vigorous exercise at baseline in relation to incidence of breast cancer by age, BMI, parity, family history of breast cancer, menopausal status, and age
h/wk Cases IRRa (95% CI) Cases IRR (95% CI) Pinteraction Age < 50 Age ≥ 50 <1 287 1.00 (Ref.) 486 1.00 (Ref.) 1 55 0.77 (0.58–1.03) 62 0.90 (0.69–1.18) 2 63 0.84 (0.64–1.11) 86 1.12 (0.88–1.41) 3–4 75 0.83 (0.64–1.08) 84 1.02 (0.80–1.29) 5–6 31 0.74 (0.51–1.08) 38 1.02 (0.73–1.43) ≥7 26 0.57 (0.38–0.86) 37 0.91 (0.65–1.27) Ptrend = 0.003 Ptrend = 0.98 0.44 BMI < 30 BMI ≥ 30 <1 418 1.00 (Ref.) 350 1.00 (Ref.) 1 71 0.86 (0.67–1.11) 45 0.83 (0.61–1.13) 2 101 1.09 (0.88–1.36) 48 0.85 (0.62–1.15) 3–4 110 0.98 (0.79–1.21) 49 0.88 (0.65–1.19) 5–6 50 0.96 (0.71–1.30) 18 0.74 (0.46–1.19) ≥7 41 0.73 (0.53–1.01) 22 0.81 (0.52–1.25) Ptrend = 0.24 Ptrend = 0.08 0.28 Nulliparous Parous <1 137 1.00 (Ref.) 636 1.00 (Ref.) 1 19 0.69 (0.40–1.04) 98 0.90 (0.73–1.12) 2 29 0.82 (0.54–1.23) 120 1.05 (0.86–1.28) 3–4 48 1.12 (0.80–1.59) 111 0.87 (0.71–1.07) 5–6 16 0.79 (0.46–1.34) 53 0.92 (0.69–1.23) ≥7 18 0.70 (0.48–1.31) 45 0.72 (0.53–0.97) Ptrend = 0.55 Ptrend = 0.05 0.26 Family history: yes Family history: no <1 123 1.00 (Ref.) 650 1.00 (Ref.) 1 16 0.73 (0.43–1.24) 101 0.87 (0.70–1.07) 2 23 1.04 (0.66–1.64) 126 0.99 (0.82–1.20) 3–4 28 1.05 (0.68–1.60) 131 0.91 (0.75–1.11) 5–6 11 0.88 (0.47–1.65) 58 0.89 (0.68–1.17) ≥7 10 0.75 (0.39–1.44) 53 0.74 (0.56–0.99) Ptrend = 0.59 Ptrend = 0.05 0.97 Premenopausal Postmenopausal <1 238 1.00 (Ref.) 425 1.00 (Ref.) 1 52 0.88 (0.65–1.19) 47 0.81 (0.60–1.09) 2 63 0.99 (0.75–1.31) 65 1.01 (0.78–1.31) 3–4 74 0.99 (0.76–1.29) 65 0.94 (0.72–1.22) 5–6 32 0.89 (0.61–1.30) 27 0.85 (0.60–1.33) ≥7 24 0.64 (0.42–0.98) 32 0.94 (0.66–1.36) Ptrend = 0.13 Ptrend = 0.55 0.76 ↵aIRRs adjusted for age (single year), questionnaire cycle, years of education (≤12, 13–14, 16, ≥17), parity (0, 1, 2, ≥3), vegetable/fruit dietary pattern (quintiles), and meat/fried foods dietary pattern (quintiles).
- Table 5.
Sitting watching TV and sitting at work in 1995 in relation to incidence of breast cancer overall and ER+ and ER− breast cancer
All breast cancer ER+ breast cancer ER− breast cancer h/d Cases Person-years IRRa (95% CI) Cases IRR (95% CI) Cases IRR (95% CI) TV <1 158 72,748 1.00 (Ref.) 84 1.00 (Ref.) 43 1.00 (Ref.) 1–2 540 236,342 1.05 (0.88–1.26) 288 1.06 (0.83–1.35) 161 1.18 (0.84–1.65) 3–4 430 206,362 0.97 (0.80–1.16) 212 0.90 (0.70–1.17) 128 1.09 (0.77–1.55) 5+ 205 86,367 1.13 (0.91–1.40) 88 0.94 (0.69–1.28) 67 1.39 (0.94–2.07) Ptrend = 0.66 Ptrend = 0.25 Ptrend = 0.24 Work <1 260 110,837 1.00 (Ref.) 136 1.00 (Ref.) 71 1.00 (Ref.) 1–2 164 70,811 1.06 (0.87–1.30) 89 1.06 (0.80–1.39) 48 1.10 (0.76–1.60) 3–4 257 105,176 1.15 (0.96–1.37) 146 1.19 (0.94–1.52) 56 0.89 (0.62–1.27) 5+ 635 301,221 1.05 (0.90–1.22) 294 0.92 (0.74–1.13) 211 1.19 (0.90–1.57) Ptrend = 0.68 Ptrend = 0.26 Ptrend = 0.21 ↵aIRRs adjusted for age (single year), time period (questionnaire cycle), BMI (<25, 25–29, ≥30 kg/m2), years of education (≤12, 13–15, 16, ≥17), parity (0, 1, 2, ≥3), vegetable/fruit dietary pattern (quintiles), meat/fried foods dietary pattern (quintiles), and vigorous activity; sitting watching TV adjusted for sitting at work and vice versa.
- Table 6.
Vigorous exercise together with combined sitting watching TV and sitting at work in 1995 in relation to incidence of breast cancer overall and ER+ and ER− breast cancer
All breast cancer ER+ breast cancer ER− breast cancer h/wk Exercise h/d Sitting Cases Person-years IRRa (95% CI) Cases Person-years IRR (95% CI) Cases Person-years IRR (95% CI) <1 <5 184 72,646 1.14 (0.78–1.66) 98 72,546 0.89 (0.57–1.42) 48 72,497 1.45 (0.65–3.22) <1 5–9 352 139,461 1.24 (0.87–1.78) 180 139,268 0.93 (0.60–1.45) 104 139,200 1.73 (0.80–3.72) <1 10+ 200 83,625 1.22 (0.84–1.78) 86 83,495 0.79 (0.49–1.26) 66 83,477 1.89 (0.86–4.16) 1–4 <5 104 46,394 1.12 (0.75–1.65) 60 46,346 0.94 (0.58–1.52) 24 46,306 1.20 (0.51–2.78) 1–4 5–9 206 101,305 1.11 (0.77–1.61) 109 101,202 0.86 (0.55–1.35) 59 101,154 1.46 (0.66–3.19) 1–4 10+ 96 50,555 1.10 (0.74–1.64) 41 50,496 0.69 (0.41–1.16) 34 50,489 1.80 (0.79–4.07) 5+ <5 33 16,824 1.00 (Ref.) 23 16,814 1.00 (Ref.) 7 16,792 1.00 (Ref.) 5+ 5–9 60 34,856 0.96 (0.63–1.47) 27 34,816 0.63 (0.36–1.10) 24 34,812 1.76 (0.76–4.09) 5+ 10+ 29 20,177 0.85 (0.51–1.40) 14 20,159 0.62 (0.32–1.20) 9 20,154 1.18 (0.44–3.18) ↵aIRRs adjusted for age (single year), time period (questionnaire cycle), BMI (<25, 25–29, ≥30 kg/m2), years of education (≤12, 13–15, 16, ≥17), parity (0, 1, 2, ≥3), vegetable/fruit dietary pattern (quintiles), and meat/fried foods dietary pattern (quintiles).
Volume 23, Issue 11
