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Cancer Epidemiology, Biomarkers & Prevention
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The Increased Risk of Colon Cancer Due to Cigarette Smoking May Be Greater in Women than Men

Ranjan Parajuli, Eivind Bjerkaas, Aage Tverdal, Randi Selmer, Loïc Le Marchand, Elisabete Weiderpass and Inger T. Gram
Ranjan Parajuli
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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Eivind Bjerkaas
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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Aage Tverdal
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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Randi Selmer
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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Loïc Le Marchand
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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Elisabete Weiderpass
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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Inger T. Gram
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
1Department of Community Medicine, Faculty of Health Sciences, University of Tromsø; 2Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, Norway; 3Division of Epidemiology, Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Nydalen; 4Department of Research, Cancer Registry of Norway, Oslo, Norway; 5Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 7Department of Genetic Epidemiology, Samfundet Folkhälsan, Helsinki, Finland
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DOI: 10.1158/1055-9965.EPI-12-1351 Published May 2013
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Abstract

Background: Smoking is a recently established risk factor for colon cancer. We wanted to explore the hypothesis that women may be more susceptible to smoking-attributed colon cancer than men as one of the possible explanations for the high colon cancer risk of Norwegian women.

Methods: We followed 602,242 participants aged 19 to 67 years at enrollment in 1972–2003, by linkage to national registries through December 2007. We used Cox proportional hazard models to estimate HRs and 95% confidence intervals (CI).

Results: During a mean follow-up of 14 years, altogether 3,998 (46% women) subjects developed colon cancer. Female ever-smokers had a 19% (HR = 1.19, 95% CI = 1.09–1.32) and male ever-smokers an 8% (HR = 1.08, CI = 0.97–1.19) increased risk of colon cancer compared with never smokers. For all the four dose–response variables examined, female ever-smokers in the most exposed category of smoking initiation, (HR = 1.48, 95% CI = 1.21–1.81), of daily cigarette consumption (HR = 1.28, 95% CI = 1.06–1.55), of smoking duration (HR = 1.47, 95% CI = 1.11–1.95), and of pack-years of smoking (HR = 1.33, 95% CI = 1.11–1.57) had a significantly increased risk of more than 20% for colon cancer overall and of more than 40% for proximal colon cancer, compared with never smokers. A test for heterogeneity by gender was statistically significant only for ever smoking and risk of proximal colon cancer (Wald χ2, P = 0.02).

Conclusions: Female smokers may be more susceptible to colon cancer and especially to proximal colon cancer than male smokers.

Impact: Women who smoke are more vulnerable to colon cancer than men. Cancer Epidemiol Biomarkers Prev; 22(5); 862–71. ©2013 AACR.

  • Received December 10, 2012.
  • Revision received February 20, 2013.
  • Accepted March 4, 2013.
  • ©2013 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 22 (5)
May 2013
Volume 22, Issue 5
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The Increased Risk of Colon Cancer Due to Cigarette Smoking May Be Greater in Women than Men
Ranjan Parajuli, Eivind Bjerkaas, Aage Tverdal, Randi Selmer, Loïc Le Marchand, Elisabete Weiderpass and Inger T. Gram
Cancer Epidemiol Biomarkers Prev May 1 2013 (22) (5) 862-871; DOI: 10.1158/1055-9965.EPI-12-1351

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The Increased Risk of Colon Cancer Due to Cigarette Smoking May Be Greater in Women than Men
Ranjan Parajuli, Eivind Bjerkaas, Aage Tverdal, Randi Selmer, Loïc Le Marchand, Elisabete Weiderpass and Inger T. Gram
Cancer Epidemiol Biomarkers Prev May 1 2013 (22) (5) 862-871; DOI: 10.1158/1055-9965.EPI-12-1351
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