Protein Expression of PTEN, Insulin-Like Growth Factor I Receptor (IGF-IR), and Lethal Prostate Cancer: A Prospective Study

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada

Departments of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; 5Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital; Departments of 6Pathology and 7Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 8Molecular and Transplantation Pathology Laboratory, F. Addarii Institute of Oncology, University of Bologna, Bologna, Italy; 9Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; 10The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia; 11Department of Pathology & Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta; and 12Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada