Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Research Articles

Genetic Susceptibility Loci for Subtypes of Breast Cancer in an African American Population

Julie R. Palmer, Edward A. Ruiz-Narvaez, Charles N. Rotimi, L. Adrienne Cupples, Yvette C. Cozier, Lucile L. Adams-Campbell and Lynn Rosenberg
Julie R. Palmer
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edward A. Ruiz-Narvaez
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles N. Rotimi
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L. Adrienne Cupples
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yvette C. Cozier
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lucile L. Adams-Campbell
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lynn Rosenberg
1Slone Epidemiology Center at Boston University; 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; 3Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts; and 4Georgetown University Medical Center, Washington DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.EPI-12-0769 Published January 2013
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Most genome-wide association studies (GWAS) have been carried out in European ancestry populations; no risk variants for breast cancer have been identified solely from African ancestry GWAS data. Few GWAS hits have replicated in African ancestry populations.

Methods: In a nested case–control study of breast cancer in the Black Women's Health Study (1,199 cases/1,948 controls), we evaluated index single-nucleotide polymorphisms (SNP) in 21 loci from GWAS of European or Asian ancestry populations, overall, in subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status (ER+/PR+, n = 336; ER−/PR−, n = 229), and in triple-negative breast cancer (TNBC, N = 81). To evaluate the contribution of genetic factors to population differences in breast cancer subtype, we also examined global percent African ancestry.

Results: Index SNPs in five loci were replicated, including three associated with ER−/PR− breast cancer (TERT rs10069690 in 5p15.33, rs704010 in 10q22.3, and rs8170 in 19p13.11): per allele ORs were 1.29 [95% confidence interval (CI) 1.04–1.59], P = 0.02, 1.52 (95% CI 1.12–2.08), P = 0.01, and 1.30 (95% CI 1.01–1.68), P = 0.04, respectively. Stronger associations were observed for TNBC. Furthermore, cases in the highest quintile of percent African ancestry were three times more likely to have TNBC than ER+/PR+ cancer.

Conclusions: These findings provide the first confirmation of the TNBC SNP rs8170 in an African ancestry population, and independent confirmation of the TERT ER− SNP. Furthermore, the risk of developing ER− breast cancer, particularly TNBC, increased with increasing proportion of global African ancestry.

Impact: The findings illustrate the importance of genetic factors in the disproportionately high occurrence of TNBC in African American women. Cancer Epidemiol Biomarkers Prev; 22(1); 127–34. ©2012 AACR.

  • Received June 25, 2012.
  • Revision received October 16, 2012.
  • Accepted October 22, 2012.
  • ©2012 American Association for Cancer Research.
View Full Text
PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 22 (1)
January 2013
Volume 22, Issue 1
  • Table of Contents
  • Table of Contents (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Genetic Susceptibility Loci for Subtypes of Breast Cancer in an African American Population
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Genetic Susceptibility Loci for Subtypes of Breast Cancer in an African American Population
Julie R. Palmer, Edward A. Ruiz-Narvaez, Charles N. Rotimi, L. Adrienne Cupples, Yvette C. Cozier, Lucile L. Adams-Campbell and Lynn Rosenberg
Cancer Epidemiol Biomarkers Prev January 1 2013 (22) (1) 127-134; DOI: 10.1158/1055-9965.EPI-12-0769

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Genetic Susceptibility Loci for Subtypes of Breast Cancer in an African American Population
Julie R. Palmer, Edward A. Ruiz-Narvaez, Charles N. Rotimi, L. Adrienne Cupples, Yvette C. Cozier, Lucile L. Adams-Campbell and Lynn Rosenberg
Cancer Epidemiol Biomarkers Prev January 1 2013 (22) (1) 127-134; DOI: 10.1158/1055-9965.EPI-12-0769
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflict of Interest
    • Authors' Contributions
    • Grant Support
    • Acknowledgments
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Gallstones and Gallbladder Cancer
  • Additive Effects of Aristolochic Acid and Arsenic in UTUC
  • Provider Lifestyle Discussions
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement