Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Proffered Abstracts - Poster Presentations

Abstract 10: Interaction between obesity and variants in angiogenesis-related genes and prostate cancer aggressiveness.

Ernest K. Amankwah, Hui-Yi Lin, Thomas A. Sellers, Hyun Park, Selina Radlein, Julio Pow-Sang, Ardeshir Hakam, Xiaotao Qu, Ya-Yu Tsai and Jong Park
Ernest K. Amankwah
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hui-Yi Lin
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas A. Sellers
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hyun Park
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Selina Radlein
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julio Pow-Sang
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ardeshir Hakam
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaotao Qu
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ya-Yu Tsai
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jong Park
Moffitt Cancer Center, Tampa, FL.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.GWAS-10 Published November 2012
  • Article
  • Info & Metrics
Loading

Abstract

Introduction: Angiogenesis has been associated with Gleason score, tumor stage, progression, metastasis and survival in prostate cancer. Furthermore, obesity has been associated with aggressive prostate cancer in most studies. However, the effect of the interaction between variants in genes in the angiogenesis pathway and obesity on the risk of aggressive prostate cancer is not well studied. We hypothesized that (i) variants in angiogenesis-related genes will associate with prostate cancer aggressiveness and (ii) obesity will modify the association between the variants and prostate cancer aggressiveness.

Methods: We conducted a two-stage analysis in two independent study populations to evaluate the role of variants in the angiogenesis pathway and their interaction with body mass index (BMI, as a measure of obesity) on prostate cancer aggressiveness. In our discovery stage, we compared genotype frequencies of 2,177 SNPs in 161 angiogenesis-related genes between 659 aggressive and 492 non-aggressive cases derived from existing Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer genome-wide association study data. In the replication stage, we attempted to validate initial findings from the discovery stage in a historical cohort of 437 aggressive and 603 non-aggressive prostate cancer patients treated at the Moffitt Cancer Center from 1986 to 2003. In both data sets, aggressive disease was defined as a Gleason score≥7 or stage≥III (all others were considered non-aggressive) and obesity was defined as BMI≥30kg/m2 (all others were considered non-obese). Associations between aggressive prostate cancer and individual SNPs were evaluated using logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (95%CI). We evaluated cumulative effects of validated SNPs by summing the number of risk alleles (risk score) for each subject in the replication dataset. Interactions between validated SNPs and obesity were evaluated in the replication dataset using logistic regression models that included a product term for the ordinal coding of genotype and a binary obesity variable, as well as main effects of these variables. Associations at SNPs with statistically significant interactions were then stratified by obesity.

Results: In the discovery dataset, 279 SNPs in 75 angiogenesis related-genes had a raw p-value < 0.05. Among these 279 SNPs, 160 (57.3%) had data available in the replication dataset. Four of these SNPs (COL4A3 rs10498214, PDGFD rs488753, COL4A3 rs6436661 and ELK3 rs2268509) were significantly associated with aggressive disease in the replication dataset. A meta-analysis of the two datasets revealed an increased risk for COL4A3 rs10498214 (OR=1.58, 95%CI=1.17-2.13), PDGFD rs488753 (OR=1.46, 95%CI=1.14-1.87) and ELK3 rs2268509 (OR=1.41, 95%CI=1.17-1.70) and a reduced risk for COL4A3 rs6436661 (OR=0.73, 95%CI=0.59-0.90). In risk score analyses, patients carrying 5-8 (OR=1.63, 95%CI=1.20-2.21, P=0.007), but not 4 (OR=1.31, 95%CI=0.95-1.81, P=0.86), risk alleles of these four SNPs had a significant increased risk for aggressive disease compared to patients carrying 0-3 risk alleles. We observed an increased risk of aggressive disease for obese cases (OR=1.35, 95%CI=1.02-1.80, P=0.039) compared to non-obese cases and a statistically significant interaction between COL4A3 rs10498214 and obesity (Pinteraction=0.0098). The per minor allele (rs10498214) risk for aggressive prostate cancer increased among obese cases (OR=1.79, 95%CI=1.24-2.58, P=0.002), but not non-obese cases (OR=0.97, 95%CI=0.75-1.24, P=0.78).

Conclusion: Our findings suggest that angiogenesis gene variants influence the risk of aggressive prostate cancer and obesity may modify this association. Further studies are warranted to validate these initial findings.

Citation Format: Ernest K. Amankwah, Hui-Yi Lin, Thomas A. Sellers, Hyun Park, Selina Radlein, Julio Pow-Sang, Ardeshir Hakam, Xiaotao Qu, Ya-Yu Tsai, Jong Park. Interaction between obesity and variants in angiogenesis-related genes and prostate cancer aggressiveness. [abstract]. In: Proceedings of the AACR Special Conference on Post-GWAS Horizons in Molecular Epidemiology: Digging Deeper into the Environment; 2012 Nov 11-14; Hollywood, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2012;21(11 Suppl):Abstract nr 10.

  • ©2012 American Association for Cancer Research.
PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 21 (11 Supplement)
November 2012
Volume 21, Issue 11 Supplement
  • Table of Contents

Sign up for alerts

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Abstract 10: Interaction between obesity and variants in angiogenesis-related genes and prostate cancer aggressiveness.
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract 10: Interaction between obesity and variants in angiogenesis-related genes and prostate cancer aggressiveness.
Ernest K. Amankwah, Hui-Yi Lin, Thomas A. Sellers, Hyun Park, Selina Radlein, Julio Pow-Sang, Ardeshir Hakam, Xiaotao Qu, Ya-Yu Tsai and Jong Park
Cancer Epidemiol Biomarkers Prev November 1 2012 (21) (11 Supplement) 10; DOI: 10.1158/1055-9965.GWAS-10

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Abstract 10: Interaction between obesity and variants in angiogenesis-related genes and prostate cancer aggressiveness.
Ernest K. Amankwah, Hui-Yi Lin, Thomas A. Sellers, Hyun Park, Selina Radlein, Julio Pow-Sang, Ardeshir Hakam, Xiaotao Qu, Ya-Yu Tsai and Jong Park
Cancer Epidemiol Biomarkers Prev November 1 2012 (21) (11 Supplement) 10; DOI: 10.1158/1055-9965.GWAS-10
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
Advertisement

Related Articles

Cited By...

More in this TOC Section

Proffered Abstracts - Poster Presentations

  • Abstract 79: The relationship between abdominal fat distribution, vitamin D levels, and physical activity in colorectal cancer patients: A pilot study.
  • Abstract 81: Dietary supplement use among German colorectal cancer patients: The ColoCare Study.
  • Abstract 82: Gene expression induced by acrylamide and glycidamide in mammalian cells.
Show more Proffered Abstracts - Poster Presentations

Molecular Epidemiology and Gene-Environment Interactions

  • Abstract PR2: Pathway-based gene-environment interactions in ovarian cancer.
  • Abstract PR6: Genetically determined differences in arsenic metabolism efficiency influence risk for premalignant skin lesions in Bangladesh: Mendelian randomization and gene-environment interaction.
  • Abstract PR1: LINE-1 %5-methyl cytosine levels in prediagnostic leukocyte DNA and future bladder cancer risk among PLCO and ATBC cohort subjects.
Show more Molecular Epidemiology and Gene-Environment Interactions
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement