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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Impact of Breast Cancer Subtypes and Treatment on Survival: An Analysis Spanning Two Decades

Reina Haque, Syed A. Ahmed, Galina Inzhakova, Jiaxiao Shi, Chantal Avila, Jonathan Polikoff, Leslie Bernstein, Shelley M. Enger and Michael F. Press
Reina Haque
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Syed A. Ahmed
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Galina Inzhakova
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Jiaxiao Shi
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Chantal Avila
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Jonathan Polikoff
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Leslie Bernstein
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Shelley M. Enger
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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Michael F. Press
Authors' Affiliations: 1Kaiser Permanente Southern California, Research & Evaluation, Pasadena, California; 2Department of Population Sciences, City of Hope, Duarte, California; 3Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
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DOI: 10.1158/1055-9965.EPI-12-0474 Published October 2012
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Abstract

Background: We investigated the impact of breast cancer molecular subtypes and treatment on survival in a cohort of medically insured women followed for more than 20 years.

Methods: We examined 934 female members of an integrated health care delivery system newly diagnosed with invasive breast cancer between 1988 and 1995 and followed them through 2008. Tumors were classified into four molecular subtypes on the basis of their expression profile: luminal A; luminal B; basal-like; and HER2-enriched. We followed women from the surgery date to death, health plan disenrollment, or study's end. HR and 95% confidence intervals (CI) were fit using Cox proportional hazards models adjusting for cancer treatments and tumor characteristics.

Results: A total of 223 (23.9%) women died because of breast cancer during the 21-year study period. Compared with women with luminal A tumors, women with HER2-enriched (HR 2.56, 95% CI 1.53–4.29) and luminal B tumors (HR 1.96, 95% CI: 1.08–3.54) had roughly a two-fold increased adjusted risk of breast cancer mortality. In addition, the survival curves suggest that risk of late mortality persists in women with luminal A tumors.

Conclusion: Among women with health care coverage, molecular subtypes were important predictors of breast cancer mortality. Women with HER2-enriched tumors and luminal B subtypes had the poorest survival despite adjusting for important covariates.

Impact: In a cohort followed for more than 20 years, women with HER2-enriched tumors had worse survival, but interestingly, the survival curve for women with luminal A tumors continued to steadily decline after 10 years of follow-up. Cancer Epidemiol Biomarkers Prev; 21(10); 1848–55. ©2012 AACR.

  • Received April 19, 2012.
  • Revision received July 18, 2012.
  • Accepted July 22, 2012.
  • ©2012 American Association for Cancer Research.
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Cancer Epidemiology Biomarkers & Prevention: 21 (10)
October 2012
Volume 21, Issue 10
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Impact of Breast Cancer Subtypes and Treatment on Survival: An Analysis Spanning Two Decades
Reina Haque, Syed A. Ahmed, Galina Inzhakova, Jiaxiao Shi, Chantal Avila, Jonathan Polikoff, Leslie Bernstein, Shelley M. Enger and Michael F. Press
Cancer Epidemiol Biomarkers Prev October 1 2012 (21) (10) 1848-1855; DOI: 10.1158/1055-9965.EPI-12-0474

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Impact of Breast Cancer Subtypes and Treatment on Survival: An Analysis Spanning Two Decades
Reina Haque, Syed A. Ahmed, Galina Inzhakova, Jiaxiao Shi, Chantal Avila, Jonathan Polikoff, Leslie Bernstein, Shelley M. Enger and Michael F. Press
Cancer Epidemiol Biomarkers Prev October 1 2012 (21) (10) 1848-1855; DOI: 10.1158/1055-9965.EPI-12-0474
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