Article Figures & Data
Figures
- Figure 1.
Forest plot of fixed summary effect for ovarian cancer and asbestos exposure.
Tables
- Table 1.
Cohort and case–control studies of women exposed occupationally or environmentally to asbestos that examine ovarian cancer mortality or incidence as an outcome
Study Author (ref) Publication year Number of women exposed Type of asbestos exposure Period of follow-up Peritoneal mesothelioma cases (n) Pleural mesothelioma cases (n) Ovarian cancer cases (n) SMR (95% CI) Ovarian cancers confirmed Cohort studies Leyland gas mask workers Acheson et al. (25) 1982 757 Crocidolite 1951–1980 2 15a (5) 12 2.75 (1.42–4.81) No Blackburn gas mask workers Acheson et al. (25) 1982 570 Chrysotile 1951–1980 0 7a (1) 5 1.48 (0.48–3.44) No Employees on central register, Germany Rosler et al. (32) 1994 616 Chrysotile and crocidolite 1977–1988 4 9 2 1.09b (0.13–3.95) No Italian women compensated for asbestosis Germani et al. (27) 1999 631 Chrysotile and crocidolite 1980–1997 12 14 9 4.77 (2.18–9.06) No Population of Finnish female workers Vasama- Neuvonen et al. (33) 1999 892,591 (born between 1906 and 1945) Not stated 1971–1995 N/A N/A 5,072 SIR = 1.3 (0.9–1.8)e Yes East London asbestos factory workers Berry et al. (3) 2000 700 Crocidolite and chrysotile 1951–1980 11 14 9 2.53 (1.16–4.80) Yes— earlier report (13) Polish women diagnosed with asbestosis Szeszenia- Dabrowska et al. (24) 2002 490 Not stated 1970–1999 0 3d 1 0.79 No Turin asbestos textile factory workers Mamo et al. (29) 2004 645 Chrysotile 1981–1995 0 10 1 1.28 (0.02–7.12) No Polish asbestos cement products factory workers Wilczynska et al. (34) 2005 1,470 Not stated 1945–1999 0 3 8 1.76 (0.76–3.47) No 6 3.76f (1.38–8.18) Italian asbestos textile workers Pira et al. (30) 2005 1,077 Mixed with crocidolite 1946–1996 9c 11d 5 2.61 (0.85–6.09) No Nottingham gas mask workers McDonald et al. (12) 2006 1,154 Crocidolite 1940–2002 18 47 10 1.8 (0.9–3.3) Yes– earlier report (14) Italian asbestos cement factory workers Magnani et al. (28) 2007 777 Chrysotile and crocidolite 1965–2003 16c 39d 9 2.27 (1.04–4.32) Yes Italian wives of asbestos factory workers Ferrante et al. (26) 2007 1,780 Chrysotile and crocidolite 1965–2003 3c 21d 11 1.42 (0.71–2.54) No Wittenoom women Reid et al. (31) 2009 2,968 Crocidolite 1982–2006 1 46 11 SIR = 1.27 (0.52–2.02) Yes Case–control studies Johns Hopkins Hospital patientsg Rosenblatt et al. (36) 1992 77 cases 46 controls Not stated 1981–1985 N/A N/A 69 1.3 (0.3–3.6) respiratory exposure Yes 18 2.8 (0.9–8.8) relatives exposed to fibers Norwegian pulp and paper workers (nested case–control study) Langseth et al. (35) 2004 46 cases 184 controls Not stated 1953–1999 N/A N/A 6 2.02 (0.72–5.66) Yes -
↵aLung and pleural cancers combined (number of mesotheliomas listed on death certificates in this cohort).
-
↵bStandardized proportionate mortality ratio.
-
↵cPeritoneal cancers.
-
↵dPleural cancers.
-
↵eMedium/high exposure.
-
↵fAmong women who worked in asbestos yarn and cloth production areas (high exposure).
-
↵gFibers include asbestos, talc, and fiberglass.
-
- Table 2.
Summary statistics for asbestos exposure and incidence or mortality from ovarian cancer
Number of studies Number of cases Fixed-effects size (95% CI) Random-effects size (95% CI) Heterogeneity, χ2 Heterogeneity, degrees of freedom Heterogeneity, P All studies combined 16 5,240 1.75 (1.45–2.10) 1.80 (1.45–2.24) 17.91 15 0.268 Cohort studies only 14 5,165 1.75 (1.45–2.12) 1.83 (1.44–2.33) 17.61 13 0.173 Case–control studies only 2 75 1.69 (0.76–3.73) 1.69 (0.76–3.73) 0.29 1 0.593 All studies that reviewed ovarian pathology 7 5,186 1.54 (1.22–1.95) 1.54 (1.22–1.95) 5.72 6 0.455 Cohort studies that reviewed ovarian pathology 5 5,102 1.53 (1.20–1.95) 1.59 (1.17–2.15) 5.38 4 0.251 Studies that examined cancer incidence 4 5,158 1.29 (0.97–1.73) 1.29 (0.97–1.73) 1.08 3 0.781
July 2011
Volume 20, Issue 7
Volume 20, Issue 7
Does Exposure to Asbestos Cause Ovarian Cancer? A Systematic Literature Review and Meta-analysis
Jump to section
Advertisement