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Cancer Epidemiology, Biomarkers & Prevention
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The Analysis of Depression and Subsequent Cancer Risk in Taiwan

Ji-An Liang, Li-Min Sun, Chih-Hsin Muo, Fung-Chang Sung, Shih-Ni Chang and Chia-Hung Kao
Ji-An Liang
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Li-Min Sun
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Chih-Hsin Muo
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Fung-Chang Sung
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Shih-Ni Chang
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Chia-Hung Kao
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DOI: 10.1158/1055-9965.EPI-10-1280 Published March 2011
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Tables

  • Table 1.

    Comparisons of incidence density of cancer between depression group and nondepression group by characteristics

    VariablesDepression
    NoYes
    nCasePerson-yearsRateanCasePerson-yearsRateaRR 95% CI
    All67,3522,571474,4015.428,41932158,3415.501.02 (0.90–1.14)
    Sex
     Women40,7281,336290,0624.615,09116336,0004.530.98 (0.84–1.16)
     Men26,6241,235184,3396.703,32815822,3427.071.06 (0.89–1.25)
    Age, y
     <3016,09671115,2100.622,012814,4860.550.90 (0.43–1.86)
     30–3913,04817494,6901.841,6313911,8083.301.80 (1.27–2.54)
     40–4912,89639494,5684.171,6124311,6023.710.89 (0.65–1.22)
     50–6413,34475395,9727.851,6689211,7227.851.00 (0.81–1.24)
     ≥6511,9681,17973,96015.91,4961398,72315.91.00 (0.84–1.19)
    Occupation
     White collar34,9781,071249,0954.304,07511928,9794.110.96 (0.79–1.15)
     Blue collar22,8021,101159,6406.902,67312118,4176.570.95 (0.79–1.15)
     Others9,57239965,6666.081,6718110,9457.401.22 (0.96–1.55)
    Urbanization level
     120,272690143,7724.802,5838818,1514.851.01 (0.81–1.26)
     219,252731136,4615.362,6319518,2625.200.97 (0.78–1.20)
     312,10342984,9595.051,352549,3095.801.15 (0.87–1.52)
     415,720721109,1706.601,8538412,6196.661.01 (0.80–1.26)
    Comorbidity
     Hypertension13,7431,02890,29811.42,42217015,68110.80.95 (0.81–1.12)
     Diabetes mellitus4,71036130,21412.0898685,52012.31.03 (0.80–1.34)
     Hyperlipidemia7,00647848,4299.871,386799,3768.430.85 (0.67–1.08)
     Heart disease10,27675466,91611.32,44514715,9649.20.82 (0.68–0.98)
    • ↵aPer 1,000 person-year.

  • Table 2.

    HRs and 95% CIs of cancer associated with depression in Cox's regression analysis in different cancer

    VariableCaseMultivariate model,a HR (95% CI)
    All cancers2,8921.03 (0.91–1.15)
    Hematologic malignancyb1301.10 (0.64–1.87)
    Colorectal cancer4080.77 (0.55–1.10)
    Lung cancer3631.01 (0.65–1.58)
    Breast cancer (women only)3251.09 (0.78–1.53)
    Uterus, cervical, ovary, and vaginal cancer (women only)2081.16 (0.84–1.60)
    Prostate cancer (men only)1231.33 (0.79–2.23)
    Brain cancer351.44 (0.55–3.76)
    • ↵aAdjusted for age, sex, urbanization, and comorbidity.

    • ↵bICD-9-CM: hematologic malignancy, 200.xx–203.xx and 205.xx–208.xx; colorectal cancer, 153.xx and 154.xx; lung cancer, 162.xx; breast cancer, 174.xx and 175.xx; uterus, cervical, ovary, and vaginal cancer, 179.xx–184.xx; prostate cancer, 185.xx; brain cancer, 179.xx and 180.xx–184.xx.

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Cancer Epidemiology Biomarkers & Prevention: 20 (3)
March 2011
Volume 20, Issue 3
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The Analysis of Depression and Subsequent Cancer Risk in Taiwan
Ji-An Liang, Li-Min Sun, Chih-Hsin Muo, Fung-Chang Sung, Shih-Ni Chang and Chia-Hung Kao
Cancer Epidemiol Biomarkers Prev March 1 2011 (20) (3) 473-475; DOI: 10.1158/1055-9965.EPI-10-1280

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The Analysis of Depression and Subsequent Cancer Risk in Taiwan
Ji-An Liang, Li-Min Sun, Chih-Hsin Muo, Fung-Chang Sung, Shih-Ni Chang and Chia-Hung Kao
Cancer Epidemiol Biomarkers Prev March 1 2011 (20) (3) 473-475; DOI: 10.1158/1055-9965.EPI-10-1280
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