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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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Serum anti-Helicobacter pylori IgG antibodies and pepsinogens A and C as serological markers of chronic atrophic gastritis.

F Sitas, R Smallwood, D Jewell, P R Millard, D G Newell, S G Meuwissen, S Moses, A Zwiers and D Forman
F Sitas
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R Smallwood
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D Jewell
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P R Millard
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D G Newell
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S G Meuwissen
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S Moses
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A Zwiers
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D Forman
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DOI:  Published March 1993
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Abstract

This study was designed to test the sensitivity and specificity of serum anti-Helicobacter pylori IgG antibodies and the ratio of serum pepsinogen A to pepsinogen C (PGA:PGC) in detecting chronic atrophic gastritis (CAG) and intestinal metaplasia. Parallel gastric biopsies and a serum sample were collected from a series of 87 patients aged 20-69 years attending a routine upper endoscopy clinic. The seroprevalence (> 10 micrograms IgG/ml) of anti-H. pylori antibodies was 42.7%, and of a low PGA:PGC ratio (< 1.5) was 17.7%. A positive H. pylori IgG antibody level was more sensitive than the level of PGA:PGC in diagnosing CAG (71.4% and 25.0%, respectively), moderate CAG (86.7% and 26.7%, respectively), and intestinal metaplasia (90.9% and 50.0%, respectively). Anti-H. pylori IgG antibody levels were less specific than PGA:PGC levels in diagnosing CAG (90.9% and 93.9%, respectively), moderate CAG (78.3% and 89.1%, respectively), and intestinal metaplasia (72.6% and 92.2%, respectively). A combination of anti-H. pylori antibodies and a low PGA:PGC ratio for the detection of CAG resulted in a specificity of 100%, but the sensitivity was 21.4%.

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March 1993
Volume 2, Issue 2
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Serum anti-Helicobacter pylori IgG antibodies and pepsinogens A and C as serological markers of chronic atrophic gastritis.
F Sitas, R Smallwood, D Jewell, P R Millard, D G Newell, S G Meuwissen, S Moses, A Zwiers and D Forman
Cancer Epidemiol Biomarkers Prev March 1 1993 (2) (2) 119-123;

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Serum anti-Helicobacter pylori IgG antibodies and pepsinogens A and C as serological markers of chronic atrophic gastritis.
F Sitas, R Smallwood, D Jewell, P R Millard, D G Newell, S G Meuwissen, S Moses, A Zwiers and D Forman
Cancer Epidemiol Biomarkers Prev March 1 1993 (2) (2) 119-123;
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Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
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