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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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Research Articles

Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Women's Health Study

Anna E. Prizment, Andrew Flood, Kristin E. Anderson and Aaron R. Folsom
Anna E. Prizment
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Andrew Flood
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Kristin E. Anderson
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Aaron R. Folsom
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DOI: 10.1158/1055-9965.EPI-10-0522 Published September 2010
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Abstract

Background: We hypothesized that precancer anthropometric variables are associated with mortality among women who developed colon cancer in a prospective cohort, the Iowa Women's Health Study (IWHS).

Methods: From 1986 to 2005, 1,096 incident cases of colon cancer were identified (mean age at diagnosis, 73 years). Anthropometric characteristics were self-measured before colon cancer diagnosis (in 1986). Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for all-cause and colon-cancer mortality, adjusted for age at cancer diagnosis, stage, education, smoking status, and pack-years of smoking.

Results: During the follow-up of up to 20 years, 493 women died; 289 had colon cancer as the underlying cause. The HRs of all-cause death were increased for the highest versus lowest tertile for weight (HR, 1.39; 95% CI, 1.10-1.76; P trend = 0.005); waist to hip ratio (WHR; HR, 1.36; 95% CI, 1.08-1.72; P trend = 0.008), and waist (HR, 1.45; 95% CI, 1.15-1.82; P trend = 0.001). Compared with that for body mass index (BMI) of 18.5 to 24.9 kg/m2, HRs were increased for BMI ≥30 kg/m2 (HR, 1.45; 95% CI, 1.14-1.85) and for the few women with BMI <18.5 kg/m2 (HR, 1.89; 95% CI, 1.01-3.53). Colon cancer mortality was positively associated with WHR and waist: HR, 1.37 (95% CI, 1.02;1.85; P trend = 0.04) and 1.34 (95% CI, 1.01-1.80; P trend = 0.05), respectively, for the highest versus lowest tertile.

Conclusion: Greater precancer anthropometric measures and BMI <18.5 kg/m2 predicted poorer survival among colon cancer patients. Higher abdominal adiposity measured by WHR and waist was associated with increased risk of colon cancer death.

Impact: Prediagnostic obesity may be a modifiable risk factor for death in colon cancer patients. Cancer Epidemiol Biomarkers Prev; 19(9); 2229–37. ©2010 AACR.

  • Received May 14, 2010.
  • Revision received June 15, 2010.
  • Accepted June 25, 2010.
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Cancer Epidemiology Biomarkers & Prevention: 19 (9)
September 2010
Volume 19, Issue 9
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Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Women's Health Study
Anna E. Prizment, Andrew Flood, Kristin E. Anderson and Aaron R. Folsom
Cancer Epidemiol Biomarkers Prev September 1 2010 (19) (9) 2229-2237; DOI: 10.1158/1055-9965.EPI-10-0522

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Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Women's Health Study
Anna E. Prizment, Andrew Flood, Kristin E. Anderson and Aaron R. Folsom
Cancer Epidemiol Biomarkers Prev September 1 2010 (19) (9) 2229-2237; DOI: 10.1158/1055-9965.EPI-10-0522
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