Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease

DOI: 10.1158/1055-9965.EPI-10-0295 Published August 2010

Article Figures & Data

Table 1.

Parameters of oxidative DNA damage in the study groups

Group of patients/parameter	8-oxodG/10⁶dG level in the leukocytes' DNA	8-oxoGua excretion (nmol/mmol of creatinine)	8-oxodG excretion (nmol/mmol of creatinine)
Group 1	n = 42	n = 40	n = 39
Untreated patients with celiac disease	Mean ± SD	Mean ± SD	Mean ± SD
	6.80 ± 4.54	14.38 ± 9.29	2.48 ± 1.57
	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)
	5.33 (4.14, 7.64)^*	12.68 (7.48, 17.57)^†,^‡	2.14 (1.44, 2.95)^§
Group 2	n = 75	n = 75	n = 74
Treated patients with celiac disease	Mean ± SD	Mean ± SD	Mean ± SD
	6.16 ± 2.90	11.66 ± 9.37	2.16 ± 1.28
	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)
	5.45 (3.97, 8.03)^∥	8.68 (5.32, 13.81)	1.81 (1.24, 2.74)^¶
Group 3	n = 24	n = 23	n = 23
Control group	Mean ± SD	Mean ± SD	Mean ± SD
	4.39 ± 1.03	7.78 ± 3.46	1.59 ± 0.52
	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)
	4.20 (3.78, 4.84)	7.29 (4.67, 10.72)	1.29 (1.08, 1.95)

Abbreviation: Me, median value; Q1, the first quartile; Q3, the third quartile.

↵*Statistically significant difference versus control group (P = 0.003).
↵^†Statistically significant difference versus control group (P = 0.0006).
↵^‡Statistically significant difference versus group 2 (P = 0.02).
↵^§ Statistically significant difference versus control group (P = 0.005).
↵^∥Statistically significant difference versus control group (P = 0.006).
↵^¶Statistically significant difference versus control group (P = 0.039).

Table 2.

Plasma antioxidant parameters in the study groups

Group of patients/parameter	Plasma retinol concentration (μmol/L)	Plasma α-tocopherol concentration (μmol/L)	Plasma ascorbic acid concentration (μmol/L)	Plasma uric acid concentration (μmol/L)
Group 1	n = 43	n = 43	n = 40	n = 42
Untreated patients with celiac disease	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
	1.37 ± 0.38	23.00 ± 6.63	59.66 ± 23.86	240.07 ± 69.16
	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)
	1.39 (1.03, 1.56)^*	22.22 (18.14, 28.04)^†	61.45 (43.75, 75.55)^‡	227.35 (191.66, 289.76)
Group 2	n = 78	n = 78	n = 74	n = 75
Treated patients with celiac disease	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
	1.68 ± 0.59	26.76 ± 5.34	63.24 ± 27.38	254.95 ± 95.97
	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)
	1.58 (1.20, 2.10)	27.25 (22.93, 29.77)	61.49 (43.95, 84.14)^§	229.55 (192.35, 284.64)
Group 3	n = 20	n = 20	n = 17	n = 20
Control group	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
	1.53 ± 0.49	24.55 ± 4.93	74.34 ± 17.55	271.46 ± 66.19
	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)	Me (Q1, Q3)
	1.50 (1.08, 1.79)	24.76 (22.34, 27.09)	74.75 (59.79, 83.95)	271.46 (221.59, 322.78)