Article Figures & Data
Figures
- Figure 1.
Age-specific IRs of small intestinal cancers according to histology, gender, racial/ethnic group, and subsite, SEER-12, 1992 to 2006.
- Figure 2.
Trends in age-adjusted IRs of small intestinal cancers according to histology, gender, racial/ethnic group, and subsite, SEER-12, 1992 to 2006.
- Figure 3.
Age-specific IRs and trends in age-adjusted IRs of lymphomas of the small intestine according to histology and gender, SEER-12, 1992 to 2006.
Tables
- Table 1.
ICD-O histology codes, IRs, and RS of patients with small intestinal cancers, SEER 12, 1992 to 2006
ICD-O-3 codes Incidence* Survival† No. Rate No. 1-y RS (%) 5-y RS (%) Total 10,945 2.10 7,052 76.3 59.7 Carcinomas Adenocarcinomas NOS 8140 2,368 0.46 1,438 53.5 28.1 Mucin-producing/mucinous 8480, 8481, 8490 483 0.09 309 59.3 23.8 Arising in adenoma 8210, 8261, 8263 311 0.06 188 67.7 36.7 Other specified 8144, 8145, 8201, 8211, 8255, 8260, 8262, 8310, 8323, 8441, 8452, 8460, 8500 65 0.01 35 61.8 32.5 Other specified 8070, 8082, 8120, 8560 18 <0.01 9 ∼ ∼ NOS 8010, 8012, 8020, 8021, 8022, 8032, 8033, 8046, 8510 167 0.03 94 27.8 21.1 Neuroendocrine cancers Differentiated (carcinoids) Carcinoid, NOS 8240 3,896 0.75 2,489 91.9 82.4 Hormone specific 8153, 8156, 8241 32 0.01 24 ∼ ∼ Undifferentiated Large cell 8013, 8246 328 0.06 229 87.8 66.7 Small cell 8041 6 ∼ 5 ∼ ∼ Atypical carcinoid 8249, 8574 10 ∼ 5 ∼ ∼ Mixed endocrine-exocrine 8154, 8243, 8244, 8245 43 0.01 28 92.0 59.3 Sarcomas GIST 8935, 8936 616 0.12 396 93.3 70.3 Leiomyosarcoma 8890, 8891, 8895, 8896 307 0.06 206 84.2 44.3 Other specified 8825, 8830, 8851, 8852, 8853, 8858, 8901, 8930, 8940, 8980, 8990, 9044, 9120, 9133, 9140 76 0.01 52 56.6 38.8 Undifferentiated 8800, 8801, 8802, 8803, 8804 85 0.02 50 73.6 43.8 Lymphomas B cell Large cell 9675, 9680, 9684 1,006 0.19 691 66.1 56.6 Follicular 9690, 9691, 9695, 9698 351 0.07 252 95.6 90.7 MALT 9699 170 0.03 117 86.1 71.9 Diffuse 9670, 9671, 9673 85 0.02 58 82.1 70.7 Burkitt 9687 77 0.01 62 70.3 63.7 Other specified 9650, 9652, 9727, 9728, 9734, 9755, 9758, 9764 16 <0.01 13 ∼ ∼ T cell 9702, 9714, 9717, 9719 87 0.02 63 50.6 34.9 NHL and lymphoma NOS 9590, 9591 231 0.04 163 66.6 52.6 Other specified malignancies Melanoma 8720, 8730 9 ∼ 5 ∼ ∼ Mesothelioma 9050, 9052, 9053 5 ∼ 2 ∼ ∼ Germ cell and gonadal stromal tumors 8590, 9064, 9100 3 ∼ 3 ∼ ∼ Neuroepithelial and peripheral nerve sheath 8680, 9364, 9473, 9540, 9560 13 ∼ 9 ∼ ∼ Myeloid sarcoma 9930 3 ∼ 3 ∼ ∼ Unspecified malignancies 8000, 8001, 8004 78 0.02 54 68.8 50.9 Abbreviations: No., number of cases; ∼, incidence and RS rates are not presented for fewer than 16 and 25 cases, respectively; GIST, gastrointestinal stromal tumor; NHL, non–Hodgkin lymphoma.
- Table 2.
Age-adjusted IRs and IRRs of small intestinal cancers according to histology, gender, race, stage, and subsite, SEER-12, 1992 to 2006
Characteristic Carcinomas Neuroendocrine cancers Sarcomas Lymphomas No. IR IRR (95% CI) No. IR IRR (95% CI) No. IR IRR (95% CI) No. IR IRR (95% CI) Total 3,412 0.66 ∼ 4,315 0.83 ∼ 1,084 0.20 ∼ 2,023 0.38 ∼ Gender Females 1,618 0.55 1.00 (Reference) 2,013 0.70 1.00 (Reference) 489 0.17 1.00 (Reference) 759 0.26 1.00 (Reference) Males 1,794 0.80 1.45 (1.35-1.55) 2,302 1.00 1.42 (1.34-1.51) 595 0.24 1.43 (1.27-1.62) 1,264 0.54 2.06 (1.88-2.26) Race* Whites 2,340 0.63 1.00 (Reference) 3,246 0.88 1.00 (Reference) 732 0.20 1.00 (Reference) 1,522 0.42 1.00 (Reference) Hispanics 254 0.53 0.84 (0.73-0.96) 288 0.56 0.64 (0.56-0.72) 107 0.18 0.92 (0.73-1.14) 189 0.31 0.75 (0.63-0.89) Blacks 575 1.29 2.06 (1.87-2.26) 648 1.43 1.63 (1.50-1.78) 93 0.19 0.93 (0.74-1.16) 120 0.24 0.58 (0.47-0.70) APIs 243 0.48 0.77 (0.67-0.88) 133 0.25 0.29 (0.24-0.34) 152 0.27 1.36 (1.13-1.62) 192 0.36 0.87 (0.74-1.01) Stage Localized 780 0.15 1.00 (Reference:) 1,586 0.31 1.00 (Reference) 520 0.10 1.00 (Reference) N/A N/A Regional 1,292 0.25 1.66 (1.51-1.81) 1,473 0.28 0.93 (0.86-1.00) 224 0.04 0.43 (0.37-0.50) N/A N/A Distant 1,062 0.21 1.36 (1.24-1.49) 1,051 0.20 0.66 (0.61-0.71) 258 0.05 0.50 (0.43-0.58) N/A N/A Unspecified 278 0.05 0.36 (0.31-0.42) 205 0.04 0.13 (0.11-0.15) 82 0.02 0.15 (0.12-0.19) N/A N/A Subsite Duodenum 1,888 0.37 1.00 (Reference) 818 0.16 1.00 (Reference) 196 0.04 1.00 (Reference) 394 0.07 1.00 (Reference) Jejunum 583 0.11 0.30 (0.28-0.33) 231 0.04 0.28 (0.24-0.33) 277 0.05 1.43 (1.18-1.72) 314 0.06 0.81 (0.70-0.94) Ileum 437 0.08 0.23 (0.21-0.25) 1,966 0.38 2.39 (2.20-2.59) 203 0.04 1.06 (0.87-1.30) 507 0.10 1.29 (1.13-1.47) Unspecified 504 0.10 0.26 (0.24-0.29) 1,300 0.25 1.59 (1.46-1.74) 408 0.08 2.11 (1.77-2.52) 808 0.15 2.07 (1.83-2.34) Stage and subsite† Duodenum Localized 356 0.07 1.00 (Reference) 572 0.11 1.00 (Reference) 77 0.02 1.00 (Reference) N/A N/A Regional 730 0.14 2.05 (1.80-2.33) 58 0.01 0.10 (0.07-0.13) 46 0.01 0.60 (0.40-0.87) N/A N/A Distant 565 0.11 1.59 (1.39-1.82) 61 0.01 0.11 (0.08-0.14) 31 0.01 0.40 (0.25-0.61) N/A N/A Jejunum Localized 164 0.03 1.00 (Reference) 76 0.02 1.00 (Reference) 161 0.03 1.00 (Reference) N/A N/A Regional 229 0.04 1.40 (1.14-1.73) 92 0.02 1.20 (0.87-1.64) 45 0.01 0.28 (0.19-0.39) N/A N/A Distant 179 0.03 1.09 (0.88-1.35) 60 0.01 0.78 (0.55-1.11) 60 0.01 0.37 (0.27-0.51) N/A N/A Ileum Localized 133 0.03 1.00 (Reference) 529 0.10 1.00 (Reference) 99 0.02 1.00 (Reference) N/A N/A Regional 174 0.03 1.30 (1.03-1.64) 855 0.16 1.62 (1.45-1.81) 49 0.01 0.49 (0.34-0.70) N/A N/A Distant 118 0.02 0.88 (0.68-1.14) 544 0.10 1.03 (0.91-1.16) 47 0.01 0.48 (0.33-0.69) N/A N/A NOTE: IRs are age-adjusted to the 2000 U.S. standard population and expressed per 100,000 person-years. IRRs are based on unrounded rates.
Abbreviations: N/A, data not available.
- Table 3.
RS of small intestinal cancers according to histology, gender, race, age, calendar year, stage, and subsite, SEER-12, 1992 to 2005
Characteristic Carcinomas Neuroendocrine cancers Sarcomas Lymphomas No. 1 y (%) 5 y (%) No. 1 y (%) 5 y (%) No. 1 y (%) 5 y (%) No. 1 y (%) 5 y (%) Total 2,073 54.5 28.0 2,780 91.4 80.7 704 86.5 57.9 1,419 73.4 64.1 Gender Females 988 54.3 28.1 1,346 91.7 80.9 317 89.0 63.3 518 77.1 72.7 Males 1,085 54.8 27.8 1,434 91.2 80.6 387 84.5 53.4 901 71.3 58.9 Race Whites 1,655 54.5 29.0 2,354 92.2 81.8 632 87.8 58.7 1,329 73.4 64.1 Blacks 418 54.6 24.2 426 87.2 75.0 72 75.0 51.1 90 73.8 62.7 Age (y) <60 716 66.3 33.8 1,111 96.4 86.5 377 89.8 60.7 653 77.3 66.7 60+ 1,357 48.0 24.0 1,669 88.0 76.2 327 82.6 54.4 766 70.0 60.9 Calendar year 1992-1998 974 54.1 25.9 1,155 89.7 78.1 309 82.5 45.0 676 68.7 56.4 1999-2005 1,099 54.9 30.5 1,625 92.6 83.6 395 89.6 69.5 743 77.7 71.6 Stage Localized 423 77.8 57.5 905 91.4 88.5 322 97.0 74.8 N/A N/A N/A Regional 802 69.0 35.4 998 95.7 89.6 151 85.9 53.6 N/A N/A N/A Distant 695 27.6 3.8 757 87.5 63.9 173 74.2 37.0 N/A N/A N/A Unspecified 153 36.5 14.2 120 77.7 59.1 58 64.3 33.3 N/A N/A N/A Subsite Duodenum 1,168 47.3 24.5 491 87.8 77.5 132 76.6 55.4 282 75.8 65.9 Jejunum 380 70.8 33.6 161 93.0 80.1 181 93.3 63.6 227 74.1 60.3 Ileum 256 64.9 40.3 1,290 93.9 84.3 115 90.0 56.5 338 76.0 69.4 Unspecified 269 52.8 22.6 838 89.1 76.9 276 85.4 55.3 572 70.4 59.6 Stage and subsite* Duodenum Localized 204 66.0 46.4 344 92.9 85.6 48 99.5 82.8 N/A N/A N/A Regional 457 66.3 34.3 35 86.9 77.2 27 72.1 47.7 N/A N/A N/A Distant 371 19.0 3.5 32 66.6 40.9 23 ∼ ∼ N/A N/A N/A Jejunum Localized 98 94.0 68.3 40 95.2 83.3 98 97.3 70.5 N/A N/A N/A Regional 152 79.5 34.7 69 91.5 82.2 35 90.6 58.3 N/A N/A N/A Distant 126 42.2 3.0 51 91.7 72.5 39 89.5 54.9 N/A N/A N/A Ileum Localized 68 82.3 71.3 300 92.5 90.9 58 96.4 63.8 N/A N/A N/A Regional 112 69.5 41.3 582 97.6 92.5 28 87.0 62.4 N/A N/A N/A Distant 72 38.7 8.1 387 89.4 68.2 27 76.6 30.8 N/A N/A N/A NOTE: RS is based on cases diagnosed during 1992 to 2005 and followed through 2006.
Abbreviation: ∼, survival rates are not presented for fewer than 25 cases.
↵*Excludes cases with unspecified stage or unspecified subsite.
August 2010
Volume 19, Issue 8
Volume 19, Issue 8
Small Intestinal Cancer: a Population-Based Study of Incidence and Survival Patterns in the United States, 1992 to 2006
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