Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Collections
      • Disparities Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Collections
      • Disparities Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
Null Results in Brief

No Association between TERT-CLPTM1L Single Nucleotide Polymorphism rs401681 and Mean Telomere Length or Cancer Risk

Karen A. Pooley, Jonathan Tyrer, Mitul Shah, Kristy E. Driver, Jean Leyland, Judith Brown, Tina Audley, Lesley McGuffog, Bruce A.J. Ponder, Paul D.P. Pharoah, Douglas F. Easton and Alison M. Dunning
Karen A. Pooley
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan Tyrer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mitul Shah
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristy E. Driver
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean Leyland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Judith Brown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tina Audley
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lesley McGuffog
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruce A.J. Ponder
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul D.P. Pharoah
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglas F. Easton
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alison M. Dunning
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.EPI-10-0281 Published July 2010
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Tables

  • Table 1.

    TERT SNP genotype and mean telomere length

    TERT rs401681δΔCt (95% CI)
    Breast cancer (6,434 controls)Melanoma (979 controls)SIBS (1,655 controls)Colorectal cancer (2,246 controls)Combined (11,314 controls)
    CC0.00 reference0.00 reference0.00 reference0.00 reference0.00 reference
    CT−0.002 (−0.02 to 0.02)0.06 (0.003-0.1)−0.002 (−0.04 to 0.04)0.01 (−0.02 to 0.05)0.02 (−0.005 to 0.04)
    TT−0.02 (−0.03 to 0.02)0.03 (−0.05 to 0.1)0.03 (−0.02 to 0.08)0.004 (−0.04 to 0.05)0.04 (−0.03 to 0.04)
    Per T alleleP trend = 0.86P trend = 0.38P trend = 0.29P trend = 0.78P trend = 0.61

    NOTE: Genotype frequencies and mean telomere length, as represented by the continuous ΔCt variable, were analyzed in control samples using linear regression for the “per T allele” change in mean telomere length (δΔCt), with associated 95% CI. Analyses were adjusted for 384-well plate and age in all the studies, and for gender and family where applicable.

    • Table 2.

      TERT SNP genotype and cancer risk

      TERT rs401681OR (95% CI), P-het
      Breast cancer (6,800 cases, 6,608 controls)Colorectal cancer (2,259 cases, 2,246 controls)Melanoma (782 cases, 999 controls)
      CC1.00 reference1.00 reference1.00 reference
      CT1.02 (0.94-1.10), 0.491.09 (0.96-1.25), 0.191.01 (0.79-1.29), 0.95
      TT1.01 (0.92-1.12), 0.701.02 (0.86-1.21), 0.800.98 (0.70-1.37), 0.90
      Per T allele1.01 (0.96-1.06)1.02 (0.94-1.11)0.99 (0.84-1.17)
      P trend = 0.64P trend = 0.66P trend = 0.91

      NOTE: Genotype frequencies in cases and controls were compared using a 2 df χ2 test for heterogeneity (P-het) and a 1 df Cochran-Armitage χ2 test for trend in risk by T allele dose (P trend). Genotype-specific risks were estimated as ORs with associated 95% CI using unconditional logistic regression. For each study, the deviation of genotype distribution in controls from Hardy-Weinberg equilibrium was assessed by a χ2 test with 1 df (data not shown).

      PreviousNext
      Back to top
      Cancer Epidemiology Biomarkers & Prevention: 19 (7)
      July 2010
      Volume 19, Issue 7
      • Table of Contents
      • Table of Contents (PDF)

      Sign up for alerts

      View this article with LENS

      Open full page PDF
      Article Alerts
      Sign In to Email Alerts with your Email Address
      Email Article

      Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

      NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

      Enter multiple addresses on separate lines or separate them with commas.
      No Association between TERT-CLPTM1L Single Nucleotide Polymorphism rs401681 and Mean Telomere Length or Cancer Risk
      (Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
      (Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
      Citation Tools
      No Association between TERT-CLPTM1L Single Nucleotide Polymorphism rs401681 and Mean Telomere Length or Cancer Risk
      Karen A. Pooley, Jonathan Tyrer, Mitul Shah, Kristy E. Driver, Jean Leyland, Judith Brown, Tina Audley, Lesley McGuffog, Bruce A.J. Ponder, Paul D.P. Pharoah, Douglas F. Easton and Alison M. Dunning
      Cancer Epidemiol Biomarkers Prev July 1 2010 (19) (7) 1862-1865; DOI: 10.1158/1055-9965.EPI-10-0281

      Citation Manager Formats

      • BibTeX
      • Bookends
      • EasyBib
      • EndNote (tagged)
      • EndNote 8 (xml)
      • Medlars
      • Mendeley
      • Papers
      • RefWorks Tagged
      • Ref Manager
      • RIS
      • Zotero
      Share
      No Association between TERT-CLPTM1L Single Nucleotide Polymorphism rs401681 and Mean Telomere Length or Cancer Risk
      Karen A. Pooley, Jonathan Tyrer, Mitul Shah, Kristy E. Driver, Jean Leyland, Judith Brown, Tina Audley, Lesley McGuffog, Bruce A.J. Ponder, Paul D.P. Pharoah, Douglas F. Easton and Alison M. Dunning
      Cancer Epidemiol Biomarkers Prev July 1 2010 (19) (7) 1862-1865; DOI: 10.1158/1055-9965.EPI-10-0281
      del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
      • Tweet Widget
      • Facebook Like
      • Google Plus One

      Jump to section

      • Article
        • Abstract
        • Introduction
        • Materials and Methods
        • Results
        • Discussion
        • Disclosure of Potential Conflicts of Interest
        • Footnotes
        • References
      • Figures & Data
      • Info & Metrics
      • PDF
      Advertisement

      Related Articles

      Cited By...

      More in this TOC Section

      • Psychotropic medications and breast cancer
      • Genetic Variants and Colorectal Cancer Survival
      • Statin Use and Prostate Cancer Incidence in Manitoba, Canada
      Show more Null Results in Brief
      • Home
      • Alerts
      • Feedback
      • Privacy Policy
      Facebook   Twitter   LinkedIn   YouTube   RSS

      Articles

      • Online First
      • Current Issue
      • Past Issues

      Info for

      • Authors
      • Subscribers
      • Advertisers
      • Librarians
      • Reviewers

      About Cancer Epidemiology, Biomarkers & Prevention

      • About the Journal
      • Editorial Board
      • Permissions
      • Submit a Manuscript
      AACR logo

      Copyright © 2019 by the American Association for Cancer Research.

      Cancer Epidemiology, Biomarkers & Prevention
      eISSN: 1538-7755
      ISSN: 1055-9965

      Advertisement