Article Figures & Data
Tables
- Table 1.
TERT SNP genotype and mean telomere length
TERT rs401681 δΔCt (95% CI) Breast cancer (6,434 controls) Melanoma (979 controls) SIBS (1,655 controls) Colorectal cancer (2,246 controls) Combined (11,314 controls) CC 0.00 reference 0.00 reference 0.00 reference 0.00 reference 0.00 reference CT −0.002 (−0.02 to 0.02) 0.06 (0.003-0.1) −0.002 (−0.04 to 0.04) 0.01 (−0.02 to 0.05) 0.02 (−0.005 to 0.04) TT −0.02 (−0.03 to 0.02) 0.03 (−0.05 to 0.1) 0.03 (−0.02 to 0.08) 0.004 (−0.04 to 0.05) 0.04 (−0.03 to 0.04) Per T allele P trend = 0.86 P trend = 0.38 P trend = 0.29 P trend = 0.78 P trend = 0.61 NOTE: Genotype frequencies and mean telomere length, as represented by the continuous ΔCt variable, were analyzed in control samples using linear regression for the “per T allele” change in mean telomere length (δΔCt), with associated 95% CI. Analyses were adjusted for 384-well plate and age in all the studies, and for gender and family where applicable.
- Table 2.
TERT SNP genotype and cancer risk
TERT rs401681 OR (95% CI), P-het Breast cancer (6,800 cases, 6,608 controls) Colorectal cancer (2,259 cases, 2,246 controls) Melanoma (782 cases, 999 controls) CC 1.00 reference 1.00 reference 1.00 reference CT 1.02 (0.94-1.10), 0.49 1.09 (0.96-1.25), 0.19 1.01 (0.79-1.29), 0.95 TT 1.01 (0.92-1.12), 0.70 1.02 (0.86-1.21), 0.80 0.98 (0.70-1.37), 0.90 Per T allele 1.01 (0.96-1.06) 1.02 (0.94-1.11) 0.99 (0.84-1.17) P trend = 0.64 P trend = 0.66 P trend = 0.91 NOTE: Genotype frequencies in cases and controls were compared using a 2 df χ2 test for heterogeneity (P-het) and a 1 df Cochran-Armitage χ2 test for trend in risk by T allele dose (P trend). Genotype-specific risks were estimated as ORs with associated 95% CI using unconditional logistic regression. For each study, the deviation of genotype distribution in controls from Hardy-Weinberg equilibrium was assessed by a χ2 test with 1 df (data not shown).