Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Research Articles

Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Simon M. Collin, Chris Metcalfe, Helga Refsum, Sarah J. Lewis, Luisa Zuccolo, George Davey Smith, Lina Chen, Ross Harris, Michael Davis, Gemma Marsden, Carole Johnston, J. Athene Lane, Marta Ebbing, Kaare Harald Bønaa, Ottar Nygård, Per Magne Ueland, Maria V. Grau, John A. Baron, Jenny L. Donovan, David E. Neal, Freddie C. Hamdy, A. David Smith and Richard M. Martin
Simon M. Collin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chris Metcalfe
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helga Refsum
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah J. Lewis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luisa Zuccolo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
George Davey Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lina Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ross Harris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Davis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gemma Marsden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carole Johnston
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Athene Lane
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marta Ebbing
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kaare Harald Bønaa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ottar Nygård
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Per Magne Ueland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria V. Grau
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John A. Baron
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jenny L. Donovan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David E. Neal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Freddie C. Hamdy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. David Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard M. Martin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.EPI-10-0180 Published June 2010
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Additional Files
  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Meta-analyses of associations of circulating folate, vitamin B12, and tHcy concentrations with prostate cancer risk.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Meta-analyses of associations of circulating folate, vitamin B12, and tHcy concentrations with prostate cancer risk in prospective cohort studies.

Tables

  • Figures
  • Additional Files
  • Table 1.

    Baseline characteristics of participants stratified by case-control status

    CharacteristicMeasureCases (n = 1,461)Controls (n = 1,507)P*
    AgeMean (SD)62.5 (5.1)62.3 (5.1)0.2
    Ethnicity (white)98.5%98.7%0.3
    BMI (kg/m2)†Mean (SD)27.9 (3.7)28.2 (4.1)0.1
    Tobacco use†Current smoker20.2%17.3%0.1
    Ever smoked63.3%65.5%0.3
    Alcohol consumption in the past 12 mo†Almost daily or more often38.5%37.8%0.5
    Once or twice per week41.2%42.4%
    Once or twice per month8.5%6.9%
    Special occasions or never11.9%12.9%
    Vitamin supplement use in past 12 mo (yes/no)†7.8%7.9%0.9
    Circulating vitamin and metabolite concentrationsMedian (5th-95th percentile) CasesMedian (5th-95th percentile) ControlsP*
    Folate (nmol/L)15.9 (6.1-51.4)15.8 (6.2-52.3)0.6
    Vitamin B12 (pmol/L)307 (156-542)299 (158-521)0.1
    Holo-haptocorrin (pmol/L)247 (119-439)240 (120-425)0.04
    Holo-transcobalamin (pmol/L)57 (23-117)56 (24-119)0.9
    Total transcobalamin (pmol/L)860 (612-1,269)874 (602-1,270)0.1
    tHcy (μmol/L)11.1 (7.8-17.6)11.1 (7.7-17.7)0.9
    • ↵*χ2 test (proportions), Student's t test (means), or two-sample Wilcoxon rank-sum (Mann-Whitney) test (medians).

    • ↵†Numbers of cases and controls for whom these data were available: BMI (1,183 cases and 1,105 controls), current smoker (846 cases and 808 controls), ever smoked (1,208 cases and 1,117 controls), alcohol consumption (1,204 cases and 1,116 controls), and vitamin supplementation (875 cases and 831 controls).

  • Table 2.

    ORs for prostate cancer by categorical (quartiles) and continuous (loge-transformed) measures of plasma vitamin and metabolite concentrations

    MetaboliteQuartiles in controls (n = 1,507)All cases (n = 1,461) vs controlsLocalized cases (n = 1,298) vs controlsAdvanced cases (n = 163) vs controls
    OR* (95% CI)OR* (95% CI)OR* (95% CI)
    Folate (nmol/L)<10.81.00 (Reference)1.00 (Reference)1.00 (Reference)
    10.8-15.81.12 (0.91-1.37)1.18 (0.96-1.46)0.67 (0.39-1.18)
    15.9-26.21.18 (0.96-1.44)1.17 (0.94-1.44)1.47 (0.89-2.45)
    >26.21.01 (0.82-1.24)1.07 (0.86-1.34)0.71 (0.42-1.22)
    Ptrend†0.71.00.4
    Per loge0.94 (0.84-1.06)0.96 (0.86-1.08)0.90 (0.67-1.21)
    Pheterogeneity‡ = 0.5
    Vitamin B12 (pmol/L)<2391.00 (Reference)1.00 (Reference)1.00 (Reference)
    239-2990.91 (0.74-1.12)0.95 (0.77-1.18)0.70 (0.40-1.22)
    300-3760.99 (0.80-1.22)0.99 (0.80-1.24)0.93 (0.55-1.57)
    >3761.17 (0.95-1.43)1.20 (0.97-1.48)1.00 (0.61-1.65)
    Ptrend†0.060.050.7
    Per loge1.19 (0.98-1.43)1.21 (0.99-1.48)1.04 (0.64-1.68)
    Pheterogeneity‡ = 0.4
    Holo-haptocorrin (pmol/L)<1871.00 (Reference)1.00 (Reference)1.00 (Reference)
    187-2400.94 (0.76-1.16)0.95 (0.76-1.19)0.85 (0.50-1.44)
    241-3040.99 (0.80-1.22)1.04 (0.84-1.29)0.68 (0.39-1.19)
    >3041.27 (1.04-1.56)1.27 (1.02-1.57)1.24 (0.75-2.04)
    Ptrend†0.010.010.3
    Per loge1.21 (1.01-1.44)1.23 (1.02-1.48)1.05 (0.67-1.64)
    Pheterogeneity‡ = 0.3
    Holo-transcobalamin (pmol/L)<421.00 (Reference)1.00 (Reference)1.00 (Reference)
    42-561.08 (0.88-1.33)1.11 (0.89-1.37)1.02 (0.60-1.75)
    57-781.09 (0.89-1.34)1.12 (0.90-1.38)1.00 (0.61-1.65)
    >781.04 (0.84-1.28)1.09 (0.87-1.35)0.85 (0.50-1.44)
    Ptrend†0.90.60.5
    Per loge0.99 (0.86-1.14)1.01 (0.87-1.18)0.93 (0.66-1.32)
    Pheterogeneity‡ = 0.7
    Total transcobalamin (pmol/L)<7491.00 (Reference)1.00 (Reference)1.00 (Reference)
    749-8741.05 (0.86-1.29)1.00 (0.81-1.23)1.63 (0.94-2.83)
    875-1,0241.02 (0.83-1.25)1.00 (0.80-1.24)1.36 (0.78-2.37)
    >1,0240.84 (0.68-1.05)0.80 (0.64-1.00)1.36 (0.77-2.40)
    Ptrend†0.090.040.6
    Per loge0.76 (0.55-1.05)0.71 (0.50-0.99)1.45 (0.65-3.25)
    Pheterogeneity‡ = 0.06
    tHcy(μmol/L)<9.521.00 (Reference)1.00 (Reference)1.00 (Reference)
    9.52-11.131.10 (0.90-1.35)1.11 (0.89-1.37)0.93 (0.54-1.59)
    11.14-13.211.03 (0.84-1.27)1.01 (0.81-1.26)1.16 (0.68-1.95)
    >13.211.04 (0.84-1.28)1.01 (0.81-1.26)1.05 (0.61-1.79)
    Ptrend†1.00.80.8
    Per loge0.90 (0.69-1.19)0.88 (0.66-1.17)0.94 (0.47-1.91)
    Pheterogeneity‡ = 0.3
    • ↵*From conditional logistic regression matching on 5-y age group and recruiting center, further adjusted for exact age (continuous).

    • ↵†From conditional logistic regression matching on 5-y age group and recruiting center, further adjusted for exact age (continuous), using quartile means as a linear variable.

    • ↵‡From multinomial logistic regression, adjusted for age (continuous) and study center, using log-transformed concentration.

Additional Files

  • Figures
  • Tables
  • Supplementary Data

    Files in this Data Supplement:

    • Supplementary Table 1
    • Supplementary Table 2
PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 19 (6)
June 2010
Volume 19, Issue 6
  • Table of Contents
  • Table of Contents (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis
Simon M. Collin, Chris Metcalfe, Helga Refsum, Sarah J. Lewis, Luisa Zuccolo, George Davey Smith, Lina Chen, Ross Harris, Michael Davis, Gemma Marsden, Carole Johnston, J. Athene Lane, Marta Ebbing, Kaare Harald Bønaa, Ottar Nygård, Per Magne Ueland, Maria V. Grau, John A. Baron, Jenny L. Donovan, David E. Neal, Freddie C. Hamdy, A. David Smith and Richard M. Martin
Cancer Epidemiol Biomarkers Prev June 1 2010 (19) (6) 1632-1642; DOI: 10.1158/1055-9965.EPI-10-0180

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis
Simon M. Collin, Chris Metcalfe, Helga Refsum, Sarah J. Lewis, Luisa Zuccolo, George Davey Smith, Lina Chen, Ross Harris, Michael Davis, Gemma Marsden, Carole Johnston, J. Athene Lane, Marta Ebbing, Kaare Harald Bønaa, Ottar Nygård, Per Magne Ueland, Maria V. Grau, John A. Baron, Jenny L. Donovan, David E. Neal, Freddie C. Hamdy, A. David Smith and Richard M. Martin
Cancer Epidemiol Biomarkers Prev June 1 2010 (19) (6) 1632-1642; DOI: 10.1158/1055-9965.EPI-10-0180
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Gallstones and Gallbladder Cancer
  • Additive Effects of Aristolochic Acid and Arsenic in UTUC
  • Provider Lifestyle Discussions
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement