Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Highlights

Highlights of This Issue

DOI:  Published June 2010
  • Article
  • Info & Metrics
  • PDF
Loading

Glioma Biomarkers

Santosh et al. Page 1399
Sreekanthreddy et al. Page 1409

Two studies in this issue address the development of informative astrocytoma and glioblastoma (GBM) biomarkers. In the first study, Santosh and colleagues evaluated insulin-like growth factor binding protein isoforms 2, 3, and 5 (IGFBP-2,-3, and -5) in astrocytoma samples. The authors report that mRNA and protein expression levels of these three IGFBP isoforms were associated with increasing grades of astrocytoma malignancy. In the second study, Sreekanthreddy and colleagues used information from glioma microarray databases to identify informative serum biomarkers. The authors identify several novel serum biomarkers for glioblastoma. Specifically, they report that high serum osteopontin (OPN) levels are a poor prognostic indicator in GBMs.

Tobacco-Specific Nitrosamines and Biomarkers

Ashley et al. Page 1389

There are significant differences in the levels of carcinogenic tobaccospecific nitrosamines (TSNA) found in cigarettes from different countries. In this study, Ashley and colleagues evaluated how TSNA levels in used cigarette butts relate to the amounts of salivary nitrosamines and urinary nitrosamine metabolites of smokers from four different countries. The study reports a direct association between salivary nitrosamine and urinary nitrosamine metabolite levels. In addition, levels of both were significantly reduced in subjects smoking cigarettes with lower TSNA levels (from Canada and Australia) compared to smokers of high TSNA cigarettes (from the United States). These findings provide incentive for countries to adopt known tobacco curing practices that can lower cigarette TSNA levels.

Chronic Infection and Lung Cancer Risk

Chaturvedi et al. Page 1498

Although the bacterium, Chlamydia pneumoniae has been implicated in lung carcinogenesis, the lack of a validated marker for chronic C. pneumoniae infection has hampered the precise estimation of its role in lung cancer. Chaturvedi and colleagues studied the relationship between C. pneumoniae infection and prospective lung cancer risk by assaying the presence of antibodies against Chlamydial heat shock protein-60 (CHSP-60). They report that individuals seropositive for CHSP-60 antibodies had significantly increased lung cancer risk. CHSP-60-related risk did not differ significantly by lung cancer histology or smoking, and CHSP-60 seropositivity was associated with increased risk 2 to 5 years prior to lung cancer diagnosis. This work highlights the potential for lung cancer risk reduction through treatments targeting chronic pulmonary infection and inflammation.

Urinary Biomarkers of Oxidative Assault

Il'yasova et al. Page 1506

To help identify biomarkers that reliably monitor oxidative stress levels in humans, Il'yasova and colleagues report on the responsiveness of urinary biomarkers in breast cancer patients undergoing doxorubicinbased chemotherapy. The study monitored five urinary biomarkers of oxidative lipid modification: four F2-isoprostanes and one oxidative product of uric acid (allantoin). This study found that in all subjects, the levels of all five urinary biomarkers increased following doxorubicin chemotherapy. These encouraging findings suggest the use of these biomarkers to measure oxidative stress levels in humans.

PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 19 (6)
June 2010
Volume 19, Issue 6
  • Table of Contents
  • Table of Contents (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Highlights of This Issue
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Highlights of This Issue
Cancer Epidemiol Biomarkers Prev June 1 2010 (19) (6) 1387;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Highlights of This Issue
Cancer Epidemiol Biomarkers Prev June 1 2010 (19) (6) 1387;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Glioma Biomarkers
    • Tobacco-Specific Nitrosamines and Biomarkers
    • Chronic Infection and Lung Cancer Risk
    • Urinary Biomarkers of Oxidative Assault
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Selected Articles from This Issue
  • Selected Articles from This Issue
  • Selected Articles from This Issue
Show more Highlights
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement