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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Reproducibility of Plasma, Red Blood Cell, and Urine Biomarkers among Premenopausal and Postmenopausal Women from the Nurses' Health Studies

Joanne Kotsopoulos, Shelley S. Tworoger, Hannia Campos, Fung-Lung Chung, Charles V. Clevenger, Adrian A. Franke, Christos S. Mantzoros, Vincent Ricchiuti, Walter C. Willett, Susan E. Hankinson and A. Heather Eliassen
Joanne Kotsopoulos
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Shelley S. Tworoger
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Hannia Campos
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Fung-Lung Chung
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Charles V. Clevenger
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Adrian A. Franke
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Christos S. Mantzoros
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Vincent Ricchiuti
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Walter C. Willett
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Susan E. Hankinson
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A. Heather Eliassen
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DOI: 10.1158/1055-9965.EPI-09-1318 Published April 2010
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  • Table 1.

    ICCs over 2 to 3 y for dietary biomarkers, among postmenopausal women in the NHS

    AnalyteNo. of participants/number of time pointsCV* (%)Median (5th-95th percentile)Within-person CV (%)Between-person CV (%)ICC (95% CI)
    Carotenoids, retinol, tocopherols, plasma (μg/L)
     Lutein/zeaxanthin40/24.8228 (102–428)19.438.90.80 (0.66–0.89)
     β-Cryptptoxanthin40/24.293.3 (42.4–231.5)17.948.50.88 (0.79–0.93)
     Total lycopene40/24.7414 (195–691)21.737.30.74 (0.58–0.86)
     α-Carotene40/28.269.6 (28.5–233)34.958.70.73 (0.57–0.85)
     Total β-carotene40/24.7288 (86.9–711)32.954.70.73 (0.56–0.85)
     Total carotenoids†40/24.41,098 (511–2,077)18.538.60.81 (0.68–0.89)
     Retinol40/24.9571 (402–798)9.618.90.79 (0.65–0.88)
     γ-Tocopherol40/26.42,295 (398–4,328)24.666.00.88 (0.78–0.93)
     α-Tocopherol40/25.911,535 (7,336–22,844)13.229.80.83 (0.72–0.91)
    Fatty acids, red blood cell (% of total fatty acids)
     Saturated40/24.2‡35.6 (30.5–38.3)5.34.20.38 (0.17–0.65)
     Monounsaturated40/25.815.4 (13.2–16.6)5.05.30.52 (0.30–0.73)
     Polyunsaturated-Ω-340/25.14.9 (3.7–6.6)10.515.30.68 (0.49–0.82)
     Polyunsaturated-Ω-640/23.228.1 (24.9–30.0)5.04.10.39 (0.17–0.66)
     Trans40/210.40.99 (0.76–1.64)12.119.70.72 (0.55–0.84)
    Vitamin D, plasma
     25-Hydroxyvitamin D (ng/mL)71/310.333.3 (16.6–51.8)18.429.60.72 (0.62–0.80)
     1,25-Dihydroxyvitamin D (pg/mL)71/318.335.7 (21.0–61.0)20.723.50.56 (0.43–0.68)
    Phytoestrogens, plasma (nmol/L)
     Daidzein40/23.64.05 (0.25–76.2)123.80.00.00
     Genistein40/25.72.70 (0.40–50.5)143.431.10.03 (0.00–1.00)
     Equol40/237.70.60 (0.00–1.40)53.50.00.00
     Enterolactone40/24.112.3 (3.10–47.0)61.254.90.44 (0.22–0.68)
    Phytoestrogens, urine (nmol/mg creatinine)
     Daidzein45/212.30.23 (0.04–2.43)128.10.00.00
     Genistein45/210.60.11 (0.01–1.12)131.024.50.02 (0.00–1.00)
     Equol45/25.40.04 (0.01–0.29)8.93.00.09 (0.00–0.77)
     Enterolactone45/25.21.44 (0.06–7.07)95.3100.00.52 (0.31–0.72)
    Isothiocyanates, urine (jm/mg creatinine)45/29.80.02 (0.00–0.12)6.73.20.18 (0.03–0.60)
    • ↵*CV, CV from blinded quality control replicates.

    • ↵†Total carotenoids, α-carotene + total β-carotene + total lycopene + lutein/zeaxanthin + β-cryptptoxanthin.

    • ↵‡CVs for the individual factors were <20% except for decanoic acid, dodecanoic acid, 9c-tetradecenoic acid, 10c-heptadecenoic acid, 8c-eicosenoic acid, 9t-tetadecenoic acid, 9t,12t-octadecadienoic acid, and 9t,12c-octadecadienoic acid, which had CVs of ≥20.

  • Table 2.

    ICCs over 2 to 3 y for stress hormones among premenopausal women in the NHSII

    AnalyteNo. of participants/number of time pointsCV (%)Median (5th-95th percentile)Within-person CVBetween-person CVICC (95% CI)
    Catecholamines, urine (μg/g creatinine)
     Norepinephrine38/32.424 (11–51)35.728.80.38 (0.19–0.62)
     Dopamine38/33.1192 (113–255)18.216.80.45 (0.27–0.64)
    Free cortisol, urine (μg/g creatinine)38/34.517.8 (4.1–84.3)80.647.30.25 (0.09–0.51)
    Free cortisol, plasma (μg/dl)
     Follicular38/212.80.96 (0.30–2.39)60.912.00.02 (0.00–1.00)
     Luteal38/210.20.99 (0.24–2.50)68.90.00.00
     Average38/211.51.02 (0.54–2.10)43.414.50.09 (0.00–0.91)
    Total cortisol, plasma (μg/dl)
     Follicular38/29.114.0 (7.00–24.0)34.220.40.25 (0.06–0.62)
     Luteal38/27.115.0 (7.00–24.0)32.326.00.38 (0.16–0.66)
     Average38/28.114.5 (8.50–23.0)24.921.00.41 (0.18–0.67)
  • Table 3.

    ICCs over 2 to 3 y for other cancer-related biomarkers among premenopausal and postmenopausal women in the NHS and NHSII

    AnalyteNo. of participants/number of time pointsCV (%)Median (5th-95th percentile)Within-person CVBetween-person CVICC (95% CI)
    Postmenopausal
     MMPs, plasma (ng/mL)
      MMP140/210.51.42 (0.28–5.24)26.485.50.91 (0.84–0.95)
      MMP240/217.8158 (119–204)9.815.00.69 (0.51–0.83)
      MMP340/210.48.67 (5.56–16.3)25.927.70.52 (0.31–0.73)
      MMP740/217.52.04 (1.28–4.33)17.333.00.78 (0.62–0.88)
      MMP940/213.872.3 (30.8–286)62.418.30.07 (0.00–0.91)
     BSL, plasma (ng/mL)68/324.98.30 (3.00–27.2)39.050.80.62 (0.50–0.73)
     Soluble leptin receptor, plasma (ng/mL)35/27.44.33 (3.74–4.69)12.026.00.82 (0.68–0.90)
     Resistin, plasma (ng/mL)35/212.02.34 (1.85–3.14)18.532.00.74 (0.57–0.86)
     Melatonin, plasma (pg/mL)40/211.54.46 (1.85–52.09)57.977.40.63 (0.44–0.79)
    Premenopausal
     Melatonin, plasma (pg/mL)40/26.97.19 (0.17–85.3)88.280.00.44 (0.22–0.68)

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Cancer Epidemiology Biomarkers & Prevention: 19 (4)
April 2010
Volume 19, Issue 4
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Reproducibility of Plasma, Red Blood Cell, and Urine Biomarkers among Premenopausal and Postmenopausal Women from the Nurses' Health Studies
Joanne Kotsopoulos, Shelley S. Tworoger, Hannia Campos, Fung-Lung Chung, Charles V. Clevenger, Adrian A. Franke, Christos S. Mantzoros, Vincent Ricchiuti, Walter C. Willett, Susan E. Hankinson and A. Heather Eliassen
Cancer Epidemiol Biomarkers Prev April 1 2010 (19) (4) 938-946; DOI: 10.1158/1055-9965.EPI-09-1318

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Reproducibility of Plasma, Red Blood Cell, and Urine Biomarkers among Premenopausal and Postmenopausal Women from the Nurses' Health Studies
Joanne Kotsopoulos, Shelley S. Tworoger, Hannia Campos, Fung-Lung Chung, Charles V. Clevenger, Adrian A. Franke, Christos S. Mantzoros, Vincent Ricchiuti, Walter C. Willett, Susan E. Hankinson and A. Heather Eliassen
Cancer Epidemiol Biomarkers Prev April 1 2010 (19) (4) 938-946; DOI: 10.1158/1055-9965.EPI-09-1318
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