Article Figures & Data
Tables
- Table 1.
ICCs over 2 to 3 y for dietary biomarkers, among postmenopausal women in the NHS
Analyte No. of participants/number of time points CV* (%) Median (5th-95th percentile) Within-person CV (%) Between-person CV (%) ICC (95% CI) Carotenoids, retinol, tocopherols, plasma (μg/L) Lutein/zeaxanthin 40/2 4.8 228 (102–428) 19.4 38.9 0.80 (0.66–0.89) β-Cryptptoxanthin 40/2 4.2 93.3 (42.4–231.5) 17.9 48.5 0.88 (0.79–0.93) Total lycopene 40/2 4.7 414 (195–691) 21.7 37.3 0.74 (0.58–0.86) α-Carotene 40/2 8.2 69.6 (28.5–233) 34.9 58.7 0.73 (0.57–0.85) Total β-carotene 40/2 4.7 288 (86.9–711) 32.9 54.7 0.73 (0.56–0.85) Total carotenoids† 40/2 4.4 1,098 (511–2,077) 18.5 38.6 0.81 (0.68–0.89) Retinol 40/2 4.9 571 (402–798) 9.6 18.9 0.79 (0.65–0.88) γ-Tocopherol 40/2 6.4 2,295 (398–4,328) 24.6 66.0 0.88 (0.78–0.93) α-Tocopherol 40/2 5.9 11,535 (7,336–22,844) 13.2 29.8 0.83 (0.72–0.91) Fatty acids, red blood cell (% of total fatty acids) Saturated 40/2 4.2‡ 35.6 (30.5–38.3) 5.3 4.2 0.38 (0.17–0.65) Monounsaturated 40/2 5.8 15.4 (13.2–16.6) 5.0 5.3 0.52 (0.30–0.73) Polyunsaturated-Ω-3 40/2 5.1 4.9 (3.7–6.6) 10.5 15.3 0.68 (0.49–0.82) Polyunsaturated-Ω-6 40/2 3.2 28.1 (24.9–30.0) 5.0 4.1 0.39 (0.17–0.66) Trans 40/2 10.4 0.99 (0.76–1.64) 12.1 19.7 0.72 (0.55–0.84) Vitamin D, plasma 25-Hydroxyvitamin D (ng/mL) 71/3 10.3 33.3 (16.6–51.8) 18.4 29.6 0.72 (0.62–0.80) 1,25-Dihydroxyvitamin D (pg/mL) 71/3 18.3 35.7 (21.0–61.0) 20.7 23.5 0.56 (0.43–0.68) Phytoestrogens, plasma (nmol/L) Daidzein 40/2 3.6 4.05 (0.25–76.2) 123.8 0.0 0.00 Genistein 40/2 5.7 2.70 (0.40–50.5) 143.4 31.1 0.03 (0.00–1.00) Equol 40/2 37.7 0.60 (0.00–1.40) 53.5 0.0 0.00 Enterolactone 40/2 4.1 12.3 (3.10–47.0) 61.2 54.9 0.44 (0.22–0.68) Phytoestrogens, urine (nmol/mg creatinine) Daidzein 45/2 12.3 0.23 (0.04–2.43) 128.1 0.0 0.00 Genistein 45/2 10.6 0.11 (0.01–1.12) 131.0 24.5 0.02 (0.00–1.00) Equol 45/2 5.4 0.04 (0.01–0.29) 8.9 3.0 0.09 (0.00–0.77) Enterolactone 45/2 5.2 1.44 (0.06–7.07) 95.3 100.0 0.52 (0.31–0.72) Isothiocyanates, urine (jm/mg creatinine) 45/2 9.8 0.02 (0.00–0.12) 6.7 3.2 0.18 (0.03–0.60) ↵*CV, CV from blinded quality control replicates.
↵†Total carotenoids, α-carotene + total β-carotene + total lycopene + lutein/zeaxanthin + β-cryptptoxanthin.
↵‡CVs for the individual factors were <20% except for decanoic acid, dodecanoic acid, 9c-tetradecenoic acid, 10c-heptadecenoic acid, 8c-eicosenoic acid, 9t-tetadecenoic acid, 9t,12t-octadecadienoic acid, and 9t,12c-octadecadienoic acid, which had CVs of ≥20.
- Table 2.
ICCs over 2 to 3 y for stress hormones among premenopausal women in the NHSII
Analyte No. of participants/number of time points CV (%) Median (5th-95th percentile) Within-person CV Between-person CV ICC (95% CI) Catecholamines, urine (μg/g creatinine) Norepinephrine 38/3 2.4 24 (11–51) 35.7 28.8 0.38 (0.19–0.62) Dopamine 38/3 3.1 192 (113–255) 18.2 16.8 0.45 (0.27–0.64) Free cortisol, urine (μg/g creatinine) 38/3 4.5 17.8 (4.1–84.3) 80.6 47.3 0.25 (0.09–0.51) Free cortisol, plasma (μg/dl) Follicular 38/2 12.8 0.96 (0.30–2.39) 60.9 12.0 0.02 (0.00–1.00) Luteal 38/2 10.2 0.99 (0.24–2.50) 68.9 0.0 0.00 Average 38/2 11.5 1.02 (0.54–2.10) 43.4 14.5 0.09 (0.00–0.91) Total cortisol, plasma (μg/dl) Follicular 38/2 9.1 14.0 (7.00–24.0) 34.2 20.4 0.25 (0.06–0.62) Luteal 38/2 7.1 15.0 (7.00–24.0) 32.3 26.0 0.38 (0.16–0.66) Average 38/2 8.1 14.5 (8.50–23.0) 24.9 21.0 0.41 (0.18–0.67) - Table 3.
ICCs over 2 to 3 y for other cancer-related biomarkers among premenopausal and postmenopausal women in the NHS and NHSII
Analyte No. of participants/number of time points CV (%) Median (5th-95th percentile) Within-person CV Between-person CV ICC (95% CI) Postmenopausal MMPs, plasma (ng/mL) MMP1 40/2 10.5 1.42 (0.28–5.24) 26.4 85.5 0.91 (0.84–0.95) MMP2 40/2 17.8 158 (119–204) 9.8 15.0 0.69 (0.51–0.83) MMP3 40/2 10.4 8.67 (5.56–16.3) 25.9 27.7 0.52 (0.31–0.73) MMP7 40/2 17.5 2.04 (1.28–4.33) 17.3 33.0 0.78 (0.62–0.88) MMP9 40/2 13.8 72.3 (30.8–286) 62.4 18.3 0.07 (0.00–0.91) BSL, plasma (ng/mL) 68/3 24.9 8.30 (3.00–27.2) 39.0 50.8 0.62 (0.50–0.73) Soluble leptin receptor, plasma (ng/mL) 35/2 7.4 4.33 (3.74–4.69) 12.0 26.0 0.82 (0.68–0.90) Resistin, plasma (ng/mL) 35/2 12.0 2.34 (1.85–3.14) 18.5 32.0 0.74 (0.57–0.86) Melatonin, plasma (pg/mL) 40/2 11.5 4.46 (1.85–52.09) 57.9 77.4 0.63 (0.44–0.79) Premenopausal Melatonin, plasma (pg/mL) 40/2 6.9 7.19 (0.17–85.3) 88.2 80.0 0.44 (0.22–0.68)
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