Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Progress and Priorities
    • Collections
      • COVID-19 & Cancer Resource Center
      • Disparities Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Informing Public Health Policy
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Research Articles

Influence of High-Dose Estrogen Exposure during Adolescence on Mammographic Density for Age in Adulthood

Helen L. Jordan, John L. Hopper, Russell J. Thomson, Anne M. Kavanagh, Dorota M. Gertig, Jennifer Stone and Alison J. Venn
Helen L. Jordan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John L. Hopper
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Russell J. Thomson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne M. Kavanagh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dorota M. Gertig
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer Stone
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alison J. Venn
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.EPI-09-0434 Published January 2010
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Eligible study population and participation by treatment status.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Lowess smoothed plots illustrating the relationship between square root dense area (cm2), log total breast area (cm2), log nondense area (cm2), and percent density (%) with age at start of treatment (years).

Tables

  • Figures
  • Table 1.

    Characteristics of treated and untreated participants [mean (SD) or proportions where applicable]

    CharacteristicsTreated (n = 167)Untreated (n = 142)P
    Age (y), mean (SD)
        At interview48.4 (4.8)46.2 (4.1)<0.001
        At mammogram48.0 (4.7)45.8 (4.1)<0.001
    Postmenopausal* (%)57 (34.1)25 (17.6)0.001
    Age at menarche (y),† mean (SD)12.8 (1.6)12.8 (1.4)0.86
    Live births (%)
        036 (21.6)26 (18.3)0.48‡
        123 (13.8)11 (7.8)
        ≥2108 (64.7)105 (74)
    Age at first live birth (y), mean (SD)30.0 (4.6)29.4 (4.5)0.25
    Height (cm), mean (SD)178.4 (3.8)175.6 (4.7)<0.001
    Weight (kg), mean (SD)78.4 (16.2)79.9 (15.7)0.40
    BMI (kg/m2), mean (SD)24.6 (5.2)25.9 (4.9)0.030
    Birthweight (kg),§ mean (SD)3.6 (0.51)3.5 (0.49)0.13
    Birth length (cm),∥ mean (SD)53.2 (2.5)52.9 (2.4)0.53
    EMH-final height (cm),¶ mean (SD)2.1 (2.8)−1.0 (3.2)<0.001
    Fertility drugs (ever used; %)43 (25.8)18 (12.7)0.004
    HRT
        Ever used (%)35 (21.0)15 (10.6)0.013
        Current use (%)22 (13.2)7 (4.9)0.013
        Total use (y), mean (SD)3.9 (6.2)2.6 (3.1)0.073
    Hormonal contraceptive
        Ever used (%)161 (96.4)138 (97.2)0.70
        Current use (%)20 (12.0)22 (15.5)0.37
        Total use (y), mean (SD)10.1 (7.2)11.9 (6.7)0.028
    Family history of breast cancer: first-degree relative (%)27 (16.2)19 (13.4)0.49
    Smoking (%)
        Ever smoked88 (52.7)83 (58.4)0.31
        Currently smoke18 (10.8)17 (12.0)0.74
    Alcohol use (%)
        Never or rarely drink24 (14.3)24 (16.9)0.24
        Occasionally (less than once a week)28 (16.8)25 (17.6)
        Once or twice a week33 (19.8)34 (23.9)
        ≥3 d/wk82 (49.1)59 (41.5)
    Benign breast disease (%)37 (22.2)23 (16.2)0.19
    Endometriosis** (%)30 (18.0)16 (11.3)0.10
    Total breast area (cm2)
        Median (5th and 95th percentile range)102.6 (49.7-232.9)111.8 (57.4-236.0)
        Mean (SD)114.5 (57.2)123.9 (55.5)0.15
    Dense area (cm2)
        Median (5th and 95th percentile range)26.4 (3.1-60.0)27.8 (4.7-77.6)
        Mean (SD)27.6 (17.6)32.8 (22.8)0.022
    Nondense area (cm2)
        Median (5th and 95th percentile range)71.7 (18.5-226.9)69.2 (27.0-225.8)
        Mean (SD)87.0 (60.5)91.1 (59.8)0.55
    Percent density (%)
        Median (5th and 95th percentile range)26.8 (2.2-67.1)28.2 (2.5-66.1)
        Mean (SD)29.5 (20.4)30.8 (19.6)0.58
    • ↵*Women were defined as postmenopausal if the time since their last period was ≥52 weeks and (a) they had not started HRT before their periods ended or (b) they started HRT before their periods ended and they were ages ≥55 years.

    • ↵†Age at menarche: 1 missing.

    • ↵‡P value for ever live birth.

    • ↵§Birthweight: n = 72 treated and 112 untreated.

    • ↵∥Birth length: n = 48 treated and 58 untreated.

    • ↵¶EMH: n = 251.

    • ↵**Endometriosis: 2 missing.

  • Table 2.

    Multiple linear regression of the association between treatment and each of the mammographic measures adjusted for different sets of covariates

    CovariatesRegression coefficient (95% CI)P
    Dense area*
        None−0.45 (−0.87 to −0.04)0.032
        Age−0.30 (−0.72 to 0.12)0.16
        Age, BMI−0.45 (−0.86 to −0.04)0.032
        Age, BMI, benign breast disease, and endometriosis−0.54 (−0.95 to −0.12)0.009
    Percent density*
        None−0.17 (−0.62 to 0.28)0.47
        Age0.06 (−0.40 to 0.51)0.81
        Age, BMI−0.25 (−0.64 to 0.13)0.20
        Age, BMI, live births−0.28 (−0.67 to 0.11)0.16
        Age, BMI, live births, benign breast disease and endometriosis−0.32 (−0.70 to 0.07)0.11
    Total breast area†
        None−0.09 (−0.19 to 0.01)0.070
        Age−0.12 (−0.22 to −0.01)0.028
        Age, BMI−0.03 (−0.11 to 0.05)0.41
    Nondense area†
        None−0.08 (−0.23 to 0.08)0.32
        Age−0.14 (−0.30 to 0.01)0.072
        Age, BMI0.01 (−0.11 to 0.13)0.90
        Age, BMI, live births0.02 (−0.10 to 0.14)0.78

    NOTE: Age (years), BMI (kg/m2), HRT (current), and menopause [postmenopausal if the time since last period was ≥52 weeks and (a) had not started HRT before periods ended or (b) started HRT before periods ended and ages ≥55 years].

    • ↵*Square root transformed.

    • ↵†Log transformed.

  • Table 3.

    Adjusted least square mean (95% CI) of each of the mammographic measures for treated and untreated women

    Treated mean (95% CI), n = 167Untreated mean (95% CI), n = 142
    Dense area (cm2)*24.5 (21.8-27.2)29.1 (26.0-32.4)
    Percent density (%)†24.8 (22.4-27.4)27.7 (24.8-30.7)
    Nondense area (cm2)†71.7 (66.2-77.7)70.5 (64.7-76.9)
    Total breast area (cm2)*105.6 (100.1-111.4)109.3 (103.1-115.8)
    • ↵*Adjusted for age (years) and BMI (kg/m2).

    • ↵†Adjusted for age, BMI, and number of live births.

PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 19 (1)
January 2010
Volume 19, Issue 1
  • Table of Contents
  • Table of Contents (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Influence of High-Dose Estrogen Exposure during Adolescence on Mammographic Density for Age in Adulthood
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Influence of High-Dose Estrogen Exposure during Adolescence on Mammographic Density for Age in Adulthood
Helen L. Jordan, John L. Hopper, Russell J. Thomson, Anne M. Kavanagh, Dorota M. Gertig, Jennifer Stone and Alison J. Venn
Cancer Epidemiol Biomarkers Prev January 1 2010 (19) (1) 121-129; DOI: 10.1158/1055-9965.EPI-09-0434

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Influence of High-Dose Estrogen Exposure during Adolescence on Mammographic Density for Age in Adulthood
Helen L. Jordan, John L. Hopper, Russell J. Thomson, Anne M. Kavanagh, Dorota M. Gertig, Jennifer Stone and Alison J. Venn
Cancer Epidemiol Biomarkers Prev January 1 2010 (19) (1) 121-129; DOI: 10.1158/1055-9965.EPI-09-0434
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Gallstones and Gallbladder Cancer
  • Additive Effects of Aristolochic Acid and Arsenic in UTUC
  • Provider Lifestyle Discussions
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement