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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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GSTP1-1 in Ovarian Cyst Fluid and Disease Outcome of Patients With Ovarian Cancer

Eva Kolwijck, Petra L.M. Zusterzeel, Hennie M.J. Roelofs, Jan C. Hendriks, Wilbert H.M. Peters and Leon F.A.G. Massuger
Eva Kolwijck
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Petra L.M. Zusterzeel
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Hennie M.J. Roelofs
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Jan C. Hendriks
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Wilbert H.M. Peters
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Leon F.A.G. Massuger
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DOI: 10.1158/1055-9965.EPI-09-0098 Published August 2009
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    Figure 1.

    The boxplots of the GSTP1-1 (ng/mL) concentrations in oCF by histologic subtype of patients with malignant (n = 56), borderline (n = 21), and benign (n = 88) ovarian tumors.

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    Figure 2.

    Kaplan-Meier estimates of DFS (A) and of OS (B) of patients who received chemotherapy (n = 30). The group with low GSTP1-1 values (≤160 ng/mL; solid line) and the group with high GSTP1-1 values (>160 ng/mL; broken line) include 12 and 18 patients, respectively. Vertical bars, patients with censored data.

Tables

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  • Table 1.

    Median (range) GSTP1-1 cyst fluid concentrations (ng/mL) by clinicopathologic parameters and of patients with EOC (n = 56)

    n (%)Cyst fluid medianGSTP1-1 (range)P
    FIGO stage0.010*
        I + II27 (48)162(10-1,302)
        III + IV28 (50)703(10-32,695)
        Unknown1 (2)
    Tumor grade0.044*
        Low-grade14 (25)89(10-1,302)
        High-grade37 (66)448(10-32,695)
        Unknown5 (9)
    Histology0.264†
        Serous24 (43)224(10-25,963)
        Mucinous15 (27)114(10-32,695)
        Endometrioid12 (21)447(28-3,583)
        Other‡5 (9)881(362-2,384)
    Residual tumor0.301*
        <1 cm38 (68)299(10-3,583)
        ≥1 cm18 (32)617(10-32,695)
    Malignant cells in ascites0.101*
        No25 (45)162(12-13,020)
        Yes28 (50)535(10-32,695)
        Unknown3 (5)
    Preoperative CA 1250.010*
        ≤126 U/mL27 (48)114(10-960)
        >126 U/mL26 (47)594(10-32,695)
        Unknown3 (5)
    Total56 (100)383(10-32,695)
    • ↵*Mann-Whitney U test.

    • ↵†Kruskal-Wallis test.

    • ↵‡Clear cell, n = 4; undifferentiated, n = 1.

  • Table 2.

    HR with 95% CI of DFS and of OS by clinicopathologic parameters of patients with EOC who received six courses of adjuvant platinum-based chemotherapy (n = 30), using univariate Cox Regression

    nDFS(95% CI)POS(95% CI)P
    HRHR
    GSTP1-1
        Low (≤160 ng/mL)121.00(Reference)1.00(Reference)
        High (>160 ng/mL)182.79(0.97-8.04)0.058*4.50(0.97-20.92)0.055*
    FIGO stage
        I + II111.00(Reference)1.00(Reference)
        III + IV1910.17(2.25-45.99)0.003*3.12(0.84-11.59)0.089*
    Residual disease
        <1 cm181.00(Reference)1.00(Reference)
        ≥1 cm121.56(0.52-4.67)0.4241.06(0.28-4.03)0.935
    Malignant cells in ascites
        No91.00(Reference)1.00(Reference)
        Yes205.07(1.14-22.65)0.033*2.30(0.61-8.67)0.218
    Preoperative CA 125
        ≤126 U/mL111.00(Reference)1.00(Reference)
        >126 U/mL182.65(0.82-8.60)0.1044.97(1.06-23.20)0.041*
    • ↵*Parameters with a P value of ≤0.10 were selected for multivariate analysis.

  • Table 3.

    Published reports on outcomes of the relationship between GSTP1-1 levels and response to chemotherapy and survival including the methods used for tissue analysis of GSTP1-1

    ReferencenMethod used for analysis of GSTP1-1Correlation between GSTP1-1 and response to chemotherapyCorrelation between GSTP1-1 and survival
    Van der Zee et al.17High performance liquid chromatographyNo—
    Green et al.78ImmunohistochemistryYesYes
    Hamada et al.61ImmunohistochemistryYesYes
    Van der Zee et al.89ImmunohistochemistryNoNo
    Hirazono et al.36Immunohistochemistry—Yes
    Wrigley et al.66ImmunohistochemistryNoNo
    Western blottingNoNo
    Ghazal-Aswad et al.39ImmunohistochemistryNo—
    Cheng et al.20ImmunohistochemistryYes—
    Western blotting—No
    Kase et al.87ImmunohistochemistryYes—
    Satoh et al.67Immunohistochemistry—Yes
    Ikeda et al.93Immunohistochemistry—No
    Howells et al.77ImmunohistochemistryNoNo
    Saip et al.55ImmunohistochemistryNoNo
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Cancer Epidemiology Biomarkers & Prevention: 18 (8)
August 2009
Volume 18, Issue 8
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GSTP1-1 in Ovarian Cyst Fluid and Disease Outcome of Patients With Ovarian Cancer
Eva Kolwijck, Petra L.M. Zusterzeel, Hennie M.J. Roelofs, Jan C. Hendriks, Wilbert H.M. Peters and Leon F.A.G. Massuger
Cancer Epidemiol Biomarkers Prev August 1 2009 (18) (8) 2176-2181; DOI: 10.1158/1055-9965.EPI-09-0098

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GSTP1-1 in Ovarian Cyst Fluid and Disease Outcome of Patients With Ovarian Cancer
Eva Kolwijck, Petra L.M. Zusterzeel, Hennie M.J. Roelofs, Jan C. Hendriks, Wilbert H.M. Peters and Leon F.A.G. Massuger
Cancer Epidemiol Biomarkers Prev August 1 2009 (18) (8) 2176-2181; DOI: 10.1158/1055-9965.EPI-09-0098
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