Article Figures & Data
Tables
- Table 1.
Demographic and tumor characteristics of the 1,252 CaPS cases (2001-2002)
Characteristic Age at diagnosis, median (range), y 65.9 (47.3-80.4) Years of follow-up, median (range) 5.1 (0.4-6.5) Family history, n (%) None 1088 (86.9) 1 blood relative 118 (9.4) ≥2 blood relatives 46 (3.7) T stage, n (%) T1 428 (34.2) T2 377 (30.1) T3 239 (19.1) T4/N1/M1 176 (14.0) Missing 32 (2.6) Gleason, n (%) 2-5 182 (14.5) 6 405 (32.4) 7 338 (27.0) 8-10 192 (15.3) Missing 135 (10.8) Curative treatment,* n (%) 602 (48.1) Hormonal therapy,† n (%) 577 (46.1) - Table 2.
Distribution of SNPs and likelihood ratio test P values from Cox proportional hazards models of prostate cancer mortality among 1,252 cases
Gene rs number Location Variation Minor allele frequency LRT P value* Multivariate model 1† Multivariate model 2‡ COX-2 rs2745557 202 C>T 0.17 0.93 0.89 rs5275 6,365 T>C 0.35 0.24 0.48 rs4648276 3,935 T>C 0.11 0.91 0.97 rs689470 8,365 C>T 0.03 0.79 0.97 rs20432 3,100 T>G 0.14 0.76 0.94 IL-1RN rs878972 2,118 A>C 0.26 0.48 0.78 rs315934 8,111 T>C 0.19 0.98 0.99 rs3087263 10,173 G>A 0.09 0.96 0.70 rs315951 14,992 C>G 0.33 0.09 0.09 IL-6 rs1474348 1,027 G>C 0.49 0.70 0.78 rs2069845 3,268 G>A 0.48 0.15 0.29 rs1800795 −237 G>C 0.49 0.44 0.79 rs1800796 −636 G>C 0.04 0.80 0.64 rs1800797 −661 G>A 0.49 0.62 0.89 IL-10 rs1800871 −853 C>T 0.26 0.66 0.46 rs1800872 −627 C>A 0.27 0.66 0.46 rs3024509 2,483 T>C 0.07 0.89 0.94 rs3024505 5,876 C>T 0.12 0.66 0.29 rs1800896 −1,117 A>G 0.46 0.80 0.83 rs1554286 1,547 C>T 0.22 0.78 0.55 IRAK1 rs1059702 1,071 (F196S) C>T 0.12 0.86 0.79 rs7061789 4,788 T>C 0.18 0.98 0.99 rs1059703 6,434 (S532L) T>C 0.13 0.80 0.87 rs3027878 9,373 T>G 0.18 0.99 0.99 IRAK4 rs1057190 −13,656 T>C 0.11 0.36 0.40 rs4251431 −7,225 G>T 0.09 0.70 0.92 rs4251571 −2,001 A>G 0.02 0.43 0.15 rs4251459 652 T>C 0.11 0.36 0.44 rs4251487 7,987 G>C 0.02 0.58 0.44 rs4251545 18,380 (A428G) G>A 0.10 0.71 0.87 rs4251559 20,791 A>G 0.44 0.66 0.58 MIC-1 rs1058587 Exon2 +2,423 C>G 0.28 0.95 0.99 rs1059519 Exon1 +25 C>G 0.29 0.14 0.53 rs1059369 Exon1 +142 A>T 0.27 0.30 0.41 rs1227732 IVS1 +1,809 G>T 0.16 0.002§ 0.009 MyD88 rs4988453 −938 C>A 0.06 0.39 0.19 TIRAP rs646005 9,537 T>C 0.37 0.71 0.79 rs8177376 14,115 T>G 0.24 0.96 0.80 rs12290468 17,678 G>A 0.05 0.71 0.99 TLR1 rs5743551 −7,202 A>G 0.23 0.02 0.03 rs5743556 −6,399 T>C 0.15 0.21 0.35 N/A −2,299 T>C 0.18 0.82 0.98 rs5743604 −833 T>C 0.30 0.04 0.06 rs5743611 238 G>C 0.11 0.98 0.89 rs4624663 2,576 A>G 0.04 0.96 0.99 TLR2 rs3804099 596 T>C 0.43 0.58 0.61 rs3804100 1,349 T>C 0.06 0.26 0.38 TLR3 rs3775296 −7 C>A 0.18 0.78 0.94 rs5743313 2,593 C>T 0.18 0.82 0.92 rs3775291 6,301 C>T 0.30 0.92 0.44 rs5743303 −8,921 A>T 0.17 0.75 0.94 rs5743305 8,441 T>A 0.33 0.80 0.80 TLR4 rs11536889 −11,380 G>C 0.12 0.84 0.74 rs10759932 −1,607 T>C 0.15 0.99 0.86 rs2149356 IVS3−468 G>T 0.30 0.64 0.56 rs4986790 8,551 A>G 0.05 0.87 0.99 rs1927914 −2,026 A>G 0.33 0.72 0.88 rs10759933 3,622 A>C 0.05 0.99 0.96 rs5030721 9,615 G>A 0.01 0.94 0.86 rs11536871 3,748 A>C 0.02 0.92 0.97 rs7873784 12,185 G>C 0.14 0.96 0.97 rs11536891 17,050 T>C 0.14 0.86 0.99 TLR5 n/a −27,694 C>T 0.48 0.39 0.17 rs2241096 −23,799 C>T 0.12 0.98 0.92 rs2072493 1,774 A>G 0.15 0.99 0.94 rs5744174 1,845 T>C 0.48 0.73 0.56 rs1053954 2,533 A>G 0.08 0.75 0.71 TLR6 rs5743788 −2,113 C>G 0.50 0.09 0.16 rs5743795 −1,401 G>A 0.18 0.16 0.31 rs5743806 −673 G>C 0.32 0.09 0.11 rs5743810 744 C>T 0.40 0.17 0.30 rs5743815 1,279 T>C 0.02 0.71 0.93 TLR7 rs2302267 −120 T>G 0.06 0.78 0.87 rs179019 4,271 C>A 0.23 0.99 0.95 rs179016 8,744 G>C 0.41 0.32 0.58 rs1620233 12,381 C>T 0.10 0.10 0.20 rs179008 17,961 A>T 0.25 0.95 0.84 TLR8 rs1548731 −558 C>T 0.26 0.62 0.99 rs4830806 3,467 C>T 0.39 0.84 0.55 rs5744068 6,553 C>T 0.16 0.83 0.97 rs5744080 9,299 C>T 0.36 0.99 0.99 rs5744088 12,059 G>C 0.16 0.83 0.98 TLR9 rs187084 −1,486 T>C 0.44 0.009∥ 0.05 TLR10 rs11466617 −3,260 T>C 0.16 0.12 0.12 rs11466640 −1,692 C>T 0.17 0.27 0.41 rs4274855 −260 G>A 0.17 0.32 0.52 rs11096957 720 (N241H) A>C 0.37 0.04 0.06 rs11096955 1,104 (1369L) A>C 0.36 0.09 0.18 rs11466657 1,417 (1473T) T>C 0.02 0.36 0.22 rs4129009 2,332 (1775V) A>G 0.17 0.25 0.34 TNF-α rs1799724 G1−857 C>T 0.07 0.99 0.99 rs1800750 G1−376 G>A 0.01 0.72 0.81 rs3093662 G1-IVS1 −122 A>G 0.04 0.96 0.87 rs361525 G2−238 G>A 0.03 0.99 0.99 rs3093664 G2-IVS3 +51 A>G 0.07 0.56 0.79 rs3093665 G3-EX4 +499 A>C 0.01 0.44 0.29 rs1800629 TNFa −308 G>A 0.18 0.11 0.12 rs769178 G4-3′ +1402 G>T 0.07 0.99 0.99 rs1800630 G5−863 C>A 0.17 0.94 0.76 NOTE: HRs (99% CIs) are shown in Supplementary Table 1.
Abbreviations: LRT, likelihood ratio test.
↵* From a Cox proportional hazards model of the codominant genotype when the frequency of rare heterozygotes >0.05 and from a dominant genotype otherwise.
↵† Controlling for age and geographic location.
↵‡ Controlling for age, geographic location, and indicator variables for curative and hormonal treatment.
↵§ HR (99% CI) for GT/TT versus GG: 0.54 (0.34, 0.87).
↵∥ HR (99% CI) for TC versus TT: 1.57 (1.02, 2.41); CC versus TT: 1.02 (0.57, 1.84).
Additional Files
Supplementary Data, Stark, et al.
Files in this Data Supplement: