Article Figures & Data
Tables
- Table 1.
Comparison of cases and controls on demographics and selected endometrial cancer risk factors
Cases (n = 1,204) Controls (n = 1,212) P Age (mean ± SD) 54.9 ± 8.5 55.1 ± 8.5 0.75* Education (%) No formal education 7.9 11.0 Elementary education 14.1 12.9 Middle and high school 62.9 63.3 Professional, college and above 15.1 12.8 0.03† Marital status (%) Unmarried 1.5 1.1 Married or cohabiting 87.6 87.6 Separated/divorced/widowed 10.9 11.3 0.63† Family income in previous year, yuan (%) <10,000 11.6 11.2 10,000-14,999 21.7 21.3 15,000-19,999 19.9 18.5 20,000-29,999 21.9 25.6 ≥30,000 24.9 23.4 0.33† No. pregnancies (%) Never 7.4 3.6 1 16.9 13.8 2 25.2 26.0 3 22.3 24.9 4 16.9 17.6 ≥5 11.3 14.1 <0.01† Cancer among first-degree relatives (%)‡ 8.5 4.4 <0.01† Natural menopause (%) 97.0 99.1 <0.01† Oral conceptive use (%) 18.5 24.9 <0.01† Hormone replacement therapy (%) 4.4 4.0 0.66† Regular exercise (%) 28.7 33.5 0.01† Age at menarche§ 14.0 (13.0, 16.0) 15.0 (13.0, 16.0) <0.01* Age at menopause (among postmenopausal women)§ 50.3 (48.6, 52.5) 49.6 (47.3, 51.1) <0.01* Years of menstruation§ 33.3 (30.1, 36.1) 31.5 (28.2, 34.4) <0.01* BMI§ 25.2 (22.9, 28.1) 23.5 (21.4, 26.0) <0.01* Waist-to-hip circumference ratio§ 0.84 (0.81, 0.87) 0.81 (0.78, 0.85) <0.01* NOTE: Subjects with missing values were excluded from the analysis.
↵* Nonvariable test on continuous variables.
↵† χ2 test was used to compare the distribution of categorical variables.
↵‡ Family history of colorectal, endometrial, or breast cancer among first-degree relatives.
↵§ Median (25th, 75th percentile) is presented.
- Table 2.
Allele frequencies (%) of the CYP19A1 gene and haplotype distribution of CYP19A1 polymorphisms, the Shanghai Endometrial Cancer Study
Alleles Cases (%) P (HWE) Controls (%) P (HWE) P SNP rs1065779 G 1,192 (57.7) 0.08 1,129 (54.8) 0.34 0.06 T 874 (42.3) 931 (45.2) rs700519 C 1,783 (87.0) 0.51 1,780 (86.7) 0.60 0.83 T 267 (13.0) 272 (13.3) rs28566535 A 1,350 (64.9) 0.77 1,374 (66.6) 0.42 0.24 C 730 (35.1) 688 (33.4) rs752760 T 1,238 (60.3) 0.29 1,230 (61.8) 0.14 0.32 C 816 (39.7) 760 (38.2) rs1870050 A 1,515 (74.6) 0.91 1,382 (68.6) 0.57 <0.01 C 515 (25.4) 632 (31.4) Estimated frequency of CYP19A1 haplotypes (in the order of SNP 1-2-3-4-5* based on their chromosome positions) GCACA 27.8 26.2 TCATC 12.3 15.6 GCCTA 16.0 14.0 TTCTA 8.8 7.6 GCATC 8.8 9.6 TCACA 8.5 8.3 Others 18.5 17.7 Overall χ2 test P = 0.02 NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants. Common allele of the SNP is in boldface type.
↵* SNP1, rs1065779; SNP2, rs700519; SNP3, rs28566535; SNP4, rs752760; and SNP5, rs1870050.
- Table 3.
Associations between CYP19A1 genotypes and endometrial cancer risk
All subjects Premenopausal women Postmenopausal women Cases Controls OR* (95% CI) Cases Controls OR* (95% CI) Cases Controls OR* (95% CI) rs1065779 (n = 1,033) (n = 1,030) G/G 330 317 1.0 139 128 1.0 191 189 1.0 G/T 532 495 1.07 (0.90-1.27) 227 190 1.08 (0.82-1.43) 305 305 1.04 (0.84-1.31) T/T 171 218 0.78 (0.62-0.99) 79 77 0.94 (0.65-1.37) 92 141 0.68 (0.50-0.93) Ptrend 0.06 0.91 0.02 Pinteraction = 0.15 rs700519 (n = 1,025) (n = 1,026) C/C 773 774 1.0 338 300 1.0 435 474 1.0 C/T 237 232 1.03 (0.84-1.26) 102 87 1.05 (0.76-1.44) 135 145 1.01 (0.78-1.31) T/T 15 20 0.76 (0.39-1.49) 6 6 0.92 (0.29-2.90) 9 14 0.70 (0.30-1.62) Ptrend 0.84 0.91 0.74 Pinteraction = 0.73 rs28566535 (n = 1,040) (n = 1,031) A/A 436 452 1.0 187 172 1.0 249 280 1.0 A/C 478 470 1.08 (0.90-1.27) 208 191 1.03 (0.78-1.34) 270 279 1.10 (0.88-1.36) C/C 126 109 1.22 (0.92-1.61) 56 32 1.62 (1.01-2.60) 70 77 1.03 (0.72-1.46) Ptrend 0.24 0.16 0.69 Pinteraction = 0.40 rs752760 (n = 1,027) (n = 995) T/T 365 391 1.0 153 148 1.0 212 243 1.0 T/C 508 448 1.27 (1.07-1.51) 217 171 1.29 (0.98-1.71) 291 277 1.25 (1.00-1.55) C/C 154 156 1.11 (0.86-1.42) 76 63 1.18 (0.80-1.74) 78 93 1.00 (0.71-1.39) Ptrend 0.32 0.38 0.72 Pinteraction = 0.62 rs1870050 (n = 1,015) (n = 1,007) A/A 566 478 1.0 249 182 1.0 317 296 1.0 A/C 383 426 0.81 (0.68-0.97) 160 154 0.85 (0.64-1.12) 223 272 0.81 (0.65-1.01) C/C 66 103 0.58 (0.42-0.80) 29 47 0.49 (0.30-0.81) 37 56 0.65 (0.42-1.01) Ptrend <0.01 <0.01 0.01 Pinteraction = 0.54 NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants.
↵* Unconditional logistic model adjusted for age.
- Table 4.
Associations between CYP19A1 genotypes and endometrial cancer risk among postmenopausal women
BMI < 25 BMI ≥ 25 Cases Controls OR* (95% CI) Cases Controls OR* (95% CI) rs1065779 G/G 91 113 1.0 100 79 1.0 G/T 129 181 0.92 (0.67-1.25) 176 124 1.17 (0.84-1.62) T/T 40 91 0.57 (0.37-0.87) 52 50 0.86 (0.54-1.35) Ptrend 0.02 0.47 Pinteraction = 0.27 rs700519 C/C 210 286 1.0 225 188 1.0 C/T 47 89 0.72 (0.49-1.06) 88 56 1.32 (0.91-1.92) T/T 2 10 0.28 (0.06-1.27) 7 4 1.46 (0.42-5.06) Ptrend 0.03 0.15 Pinteraction = 0.01 rs28566535 A/A 121 174 1.0 128 106 1.0 A/C 116 165 0.99 (0.73-1.35) 154 114 1.16 (0.84-1.60) C/C 25 48 0.74 (0.44-1.24) 45 29 1.34 (0.80-2.23) Ptrend 0.45 0.34 Pinteraction = 0.22 rs752760 T/T 86 138 1.0 126 105 1.0 T/C 137 183 1.1 7 (0.87-1.60) 154 94 1.47 (1.05-2.04) C/C 36 53 1.07 (0.67-1.59) 42 40 0.94 (0.58-1.52) Ptrend 0.53 0.85 Pinteraction = 0.76 rs1870050 A/A 141 177 1.0 176 119 1.0 A/C 97 169 0.73 (0.54-1.00) 126 103 0.92 (0.66-1.27) C/C 17 35 0.62 (0.34-1.14) 20 21 0.71 (0.38-1.36) Ptrend 0.03 0.13 Pinteraction = 0.69 NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants.
↵* Unconditional logistic model adjusted for age.
- Table 5.
Associations between haplotyes of CYP19A1 and endometrial cancer risk
Haplotypes All subjects Premenopausal women Postmenopausal women Cases Controls OR* (95% CI) Cases Controls OR* (95% CI) Cases Controls OR* (95% CI) GCACA† 588 550 1.0 256 211 1.0 332 339 1.0 TCATC 296 367 0.76 (0.62-0.92) 126 134 0.79 (0.58-1.07) 170 233 0.75 (0.58-0.96) GCCTA 373 331 1.05 (0.87-1.27) 161 124 1.07 (0.79-1.44) 212 207 1.05 (0.82-1.34) TTCTA 193 166 1.09 (0.89-1.38) 84 62 1.11 (0.76-1.62) 109 104 1.07 (0.79-1.46) GCATC 150 168 0.83 (0.65-1.07) 61 80 0.64 (0.44-0.93) 89 88 1.04 (0.74-1.44) TCACA 183 173 0.99 (0.78-1.26) 89 67 1.06 (0.74-1.54) 94 106 0.91 (0.66-1.24) Others 301 315 0.90 (0.74-1.09) 125 114 0.90 (0.66-1.23) 176 201 0.89 (0.69-1.15) Ptrend 0.75 0.64 0.88 NOTE: The number of participants does not add up to the total number of women because of missing data on genotypes for some participants.
↵* Unconditional logistic model adjusted for age.
↵† In the order of SNP 1-2-3-4-5 based on their chromosome position (SNP1, rs1065779; SNP2, rs700519; SNP3, rs28566535; SNP4, rs752760; and SNP5, rs1870050).
Volume 16, Issue 5
