Usual Adult Body Mass Index Is Not Predictive of Ovarian Cancer Survival

DOI: 10.1158/1055-9965.EPI-06-1052 Published March 2007

Article Figures & Data

Table 1.

Characteristics of 395 ovarian cancer patients, by survival status, RPCI

Characteristic	Alive (n = 95) n (%)	Dead (n = 300) n (%)	Crude HR (95% CI)*
Age at diagnosis (y)
Mean (SD)	47.5 (14.1)	58.3 (12.3)	1.04 (1.03-1.04)
<40	27 (28.4)	22 (7.3)	Reference
40-49	28 (29.5)	52 (17.3)	1.75 (1.06-2.87)
50-59	23 (24.2)	85 (28.3)	2.92 (1.82-4.68)
≥60	17 (17.9)	141 (47.0)	3.93 (2.49-6.18)
FIGO stage
I	44 (46.3)	39 (13.2)	Reference
II	17 (17.9)	22 (7.4)	1.19 (0.71-2.02)
III	30 (31.6)	180 (60.8)	3.38 (2.38-4.79)
IV	4 (4.2)	55 (18.6)	4.36 (2.88-6.61)
Tumor grade
1: Well differentiated	33 (36.3)	32 (11.1)	Reference
2: Moderately differentiated	21 (23.1)	79 (27.5)	2.45 (1.62-3.70)
3: Poorly differentiated	36 (39.6)	166 (57.8)	2.93 (2.00-4.30)
4: Undifferentiated	1 (1.1)	10 (3.5)	3.72 (1.83-7.58)
Tumor histology
Serous	45 (47.4)	225 (75.0)	Reference
Mucinous	17 (17.9)	17 (5.7)	0.39 (0.27-0.64)
Endometrioid	24 (25.3)	30 (10.0)	0.45 (0.31-0.67)
Clear cell	8 (8.4)	20 (6.7)	0.73 (0.46-1.16)
Unknown	1 (1.1)	8 (2.7)	1.01 (0.50-20.5)
Received platinum-based chemotherapy	70 (73.7)	268 (89.3)	1.97 (1.36-2.86)
History of diabetes	3 (3.3)	25 (8.6)	1.61 (1.07-2.44)
History of hypertension	19 (20.9)	64 (22.0)	1.00 (0.76-1.32)
History of thyroid disorder	3 (3.3)	17 (5.8)	1.10 (0.67-1.79)
History of arthritis	10 (11.0)	42 (14.4)	0.96 (0.69-1.33)
History of GERD	1 (1.1)	7 (2.4)	2.30 (1.08-4.88)

Table 2.

Ovarian cancer survival by usual BMI, RPCI

	Survival in months median (range)	Alive (n = 95) n (%)	Dead (n = 300) n (%)	Crude HR (95% CI)	Adjusted HR (95% CI)*
Usual BMI (kg/m²)
Normal (BMI <25)	57 (1-283)	49 (51.6)	161 (53.7)	Reference	Reference
Overweight (BMI 25.0-29.9)	58 (5-273)	23 (24.2)	85 (28.3)	1.05 (0.81-1.37)	1.10 (0.82-1.47)
Obese (BMI ≥30)	59 (2-244)	23 (24.2)	54 (18.0)	0.90 (0.66-1.23)	0.99 (0.71-1.38)