Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Collections
      • Disparities Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CEBP Focus Archive
    • Meeting Abstracts
    • Collections
      • Disparities Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
Short Communications

Activated Checkpoint Kinase 2 Expression and Risk for Oral Squamous Cell Carcinoma

Angela J. Yoon, Jing Shen, Regina M. Santella, David J. Zegarelli, Rongzhen Chen and I.B. Weinstein
Angela J. Yoon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jing Shen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Regina M. Santella
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David J. Zegarelli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rongzhen Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I.B. Weinstein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1055-9965.EPI-07-0659 Published December 2007
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Photomicrographs of representative pChk2 immunostaining. A. Nuclear staining (brown) of the surface epithelium demonstrating considerable variation in the intensity of the stain within a given field. A diffuse staining pattern is observed (as opposed to sporadic and scattered positivity) involving full thickness of the epithelium. Magnification, ×100. B. A mitotic figure staining dark brown +3 intensity (short arrow), the golden brown staining (two arrowheads) is of +2 intensity, the lighter but discernable brown staining (two longer arrows) is of +1 intensity, and the faint brownish color (circle) was considered as background staining. A complete absence of brown stain (rectangle) was interpreted as negative staining. Magnification, ×400. The fraction of cells exhibiting nuclear staining of various intensity (0, +1, +2, and +3) was estimated and added together to formulate the cumulative score. For example, in the field shown ∼1% has +3 intensity, 15% with +2, and 30% with +1 intensity, which will yield (1% × 3) + (15% × 2) + (30% × 1) = 0.63 cumulative score. Each slide was independently reviewed thrice and then the results between two pathologists compared to assure consistency.

Tables

  • Figures
  • Table 1.

    Patient characteristics and biopsy specimens

    Case groupControl groupP
    Total no. patients4897—
    Sex
        Male (%)27 (56.3)50 (51.5)—
        Female (%)21 (43.7)47 (48.5)0.59
    No. biopsies before SCC
        One2297—
        More than one26——
    Total no. tissue specimens examined14497—
        Non-SCC9697—
        SCC48——
    Mean age at initial biopsy (SD)70.4 (10.4)57.1 (21.2)<0.001
    Time from initial biopsy to SCC
            Mean years (SD)3.2 (2.9)——
            Range (y)0.08-13——
  • Table 2.

    Status of pChk2 expression for the tissue samples in each category of histologic diagnosis

    Tissue specimens from cases (n = 144)Tissue specimens from controls (n = 97)
    Histologic diagnosispChk2 positive (%)pChk2 negative (%)pChk2 positive (%)pChk2 negative (%)
    No histologic atypia41 (28.5)16 (11.1)23 (23.7)69 (71.1)
    Atypia/dysplasia32 (22.2)7 (4.9)2 (2.1)2 (2.1)
    SCC44 (30.5)4 (2.8)——
  • Table 3.

    Mean years to SCC progression, sensitivity, specificity, accuracy, OR, and median immunostain score for precancerous lesions and SCC

    Mean years to SCC (SD)Sensitivity (%)Specificity (%)Accuracy (%)OR (95% CI)Mean score (SD)
    No histologic atypia3.0 (2.8)71.974.273.48.6 (3.7-19.8)0.39 (0.36)
    Atypia/dysplasia2.9 (2.7)82.174.276.514.3 (4.9-41.5)0.55 (0.45)
    Precancerous lesion (combined above two rows)2.976.074.275.110.5 (4.8-22.6)—
    SCC—91.774.280.029.8 (9.4-94.6)0.54 (0.40)
    Precancerous lesions progressing to SCC
        In <3 y—64.374.271.25.8 (2.4-13.8)—
        After >3 y—85.274.278.219.9 (7.3-55.5)—
PreviousNext
Back to top
Cancer Epidemiology Biomarkers & Prevention: 16 (12)
December 2007
Volume 16, Issue 12
  • Table of Contents
  • Table of Contents (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Activated Checkpoint Kinase 2 Expression and Risk for Oral Squamous Cell Carcinoma
(Your Name) has forwarded a page to you from Cancer Epidemiology, Biomarkers & Prevention
(Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention.
Citation Tools
Activated Checkpoint Kinase 2 Expression and Risk for Oral Squamous Cell Carcinoma
Angela J. Yoon, Jing Shen, Regina M. Santella, David J. Zegarelli, Rongzhen Chen and I.B. Weinstein
Cancer Epidemiol Biomarkers Prev December 1 2007 (16) (12) 2768-2772; DOI: 10.1158/1055-9965.EPI-07-0659

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Activated Checkpoint Kinase 2 Expression and Risk for Oral Squamous Cell Carcinoma
Angela J. Yoon, Jing Shen, Regina M. Santella, David J. Zegarelli, Rongzhen Chen and I.B. Weinstein
Cancer Epidemiol Biomarkers Prev December 1 2007 (16) (12) 2768-2772; DOI: 10.1158/1055-9965.EPI-07-0659
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Statin Use and Breast Cancer Risk
  • Tamoxifen and Longitudinal Mammographic Density Change
  • Cancer Predisposition Gene Mutations and Pancreatic Cancer
Show more Short Communications
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Epidemiology, Biomarkers & Prevention

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2019 by the American Association for Cancer Research.

Cancer Epidemiology, Biomarkers & Prevention
eISSN: 1538-7755
ISSN: 1055-9965

Advertisement