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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Research Articles

The Impact of Acculturation on Awareness of Genetic Testing for Increased Cancer Risk among Hispanics in the Year 2000 National Health Interview Survey

Susan T. Vadaparampil, Louise Wideroff, Nancy Breen and Edward Trapido
Susan T. Vadaparampil
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Louise Wideroff
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Nancy Breen
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Edward Trapido
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DOI: 10.1158/1055-9965.EPI-05-0378 Published April 2006
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Abstract

Previous studies suggest disparities in use of preventive cancer services among U.S. Hispanics are partly explained by knowledge and access factors. One area of emerging interest is uptake of genetic counseling and testing services by underserved populations. This study aims to estimate the percentage of Hispanics in five ethnic subgroups who are aware of genetic testing for inherited cancer risk, and to assess the influence of acculturation factors primarily related to language on test awareness. Weighted data from 4,313 Hispanic respondents (age >25 years) in the year 2000 National Health Interview Survey were analyzed. Overall, 20.6% of Hispanics had heard of genetic testing for cancer risk, with percentages highest among Puerto Ricans (27.3%) and lowest among Mexicans (14.3%). Completing the interview in Spanish and English [odds ratio (OR), 0.52; 95% confidence interval (95% CI), 0.35-0.78], or only Spanish (OR, 0.60; 95% CI, 0.42-0.86), was inversely associated with test awareness (reference group, only English). Having an intermediate (OR, 0.66; 95% CI, 0.48-0.90) or low (OR, 0.63; 95% CI, 0.39-1.01) level of English language preference was also inversely associated (reference, high level) whereas being born outside the United States was weakly associated (OR, 0.80; 95% CI, 0.57-1.11). Estimates were adjusted for age, education, ethnicity, parents' cancer history, health care access, and selected health behaviors and beliefs. Results of this national survey indicate that acculturation factors related to language may affect cancer genetic test awareness in Hispanics. These factors must be taken into account when informing individuals about the role of genetics in cancer risk and providing cancer genetic health services. (Cancer Epidemiol Biomarkers Prev 2006;15(4):618–23)

  • Health survey
  • genetic testing
  • Hispanics
  • acculturation
  • cancer risk
  • health disparity
  • awareness

Introduction

Hispanics are the fastest growing minority group in the United States and are expected to comprise 25% of the entire U.S. population by the year 2050. They are an ethnically and racially diverse group with origins in Mexico, the Caribbean, Central or South America, and Spain, tied together by a common language (1). Whereas Hispanics have lower incidence and mortality from cancers in general, they tend to be diagnosed at later stages for several cancers including the colon, prostate, lung, and breast and have lower survival rates compared with the general population (2-4). This differential in stage of cancer diagnosis among Hispanics may be partially associated with less knowledge, access, and utilization of preventive services such as cancer screening tests.

An additional area where a disparity may be emerging is in the use of cancer genetic counseling and testing services. In a national study of 646 patients who received genetic testing in community based (non-research) settings between the years 1998 and 2000, only 1% (n = 7) were Hispanic (5). As of yet, mutation prevalence, associated breast cancer risk, and the need for cancer genetic services are not well defined in Hispanics although BRCA1/2 mutations have been documented (6-14). For example, among 10,000 high-risk individuals undergoing mutation testing at a commercial laboratory who specified a single ancestry, the prevalence of BRCA1/2 mutations was 16% among Europeans, 19% among Africans, 18% among Latin Americans/Caribbeans, 14% among Native Americans, and 12% among Asians (15). Whereas review articles and reports emphasize the need for and use of genetic counseling and testing services in the Hispanic community (16-18), there are less empirical data about factors that may contribute to utilization of these services, such as awareness of their availability (5, 19).

People with basic knowledge about inherited cancer risk and awareness of genetic testing for cancer susceptibility mutations can potentially make more informed choices about whether or not to seek such services (20). However, awareness of such concepts has been shown to vary by demographic characteristics and family history (21-25). In minority groups with a significant immigrant population, such as Hispanics, acculturation factors (e.g., primary language spoken, length of residence in the United States) may also influence access to information about genetic testing through the health care system or other dissemination channels (16).

Several studies have shown that language acculturation factors (i.e., use of English versus Spanish) are directly associated with awareness of, access to, and utilization of health care services (26-31). In a 2002 national survey of >3,000 Latinos residing in the United States, only 53% of Spanish dominant speakers had health insurance compared with 74% and 75% of bilingual or English dominant speakers, respectively. Spanish dominant speakers were over six times more likely (49%) than English dominant speakers (8%) to report difficulty in communicating with their health care provider (32). Thus, language barriers and lack of health insurance may contribute to decreased access to provider discussion about preventive health services (28-31) and possibly newer medical technologies.

Limited evidence suggests this may occur with cancer genetic counseling and testing services. A previous analysis of the 2000 National Health Interview Survey (NHIS) indicates Hispanics were least likely to report having heard of genetic testing for increased cancer risk (20%) compared with African Americans (39%) and non-Hispanic whites (48%). Close to half of the Hispanic respondents reported Spanish as their only or primary spoken language, suggesting that exposure to information about inherited risk and genetic testing is partly mediated by acculturation factors (33).

No study to date has explored the effect of acculturation on awareness of genetic testing for inherited cancer susceptibility in a large, nationally representative, multiethnic sample of Hispanics residing in the United States. Although the proportion of respondents who are appropriate candidates for genetic counseling and testing is small in a national sample, valuable information can be obtained that is harder to assess in select high-risk clinical samples, where minority groups such as Hispanics are often underrepresented. First, it is possible to assess knowledge gaps that may contribute to underutilization or delayed uptake of cancer genetics services by high-risk individuals. This is particularly important for underserved Hispanic populations in the United States for whom there are little published data about use of such services (6, 14, 19, 34). Second, given the recent direct-to-consumer advertising campaigns targeting the general population (35) and translation of advertising materials into Spanish by genetic testing companies (36), identifying baseline levels of awareness may be important in developing messages about risk-appropriate use of testing. The major purpose of this study is to estimate, by ethnic subgroup, the percentage of Hispanic adults in the U.S. population who have heard of genetic tests for inherited cancer susceptibility and to assess the influence of acculturation factors on test awareness.

Materials and Methods

Survey Methods

The NHIS, conducted annually by the National Center for Health Statistics (Centers for Disease Control and Prevention, Hyattsville, MD), employs a stratified multistage sampling design in which African Americans and Hispanics are oversampled. An in-person, computer-assisted household interview is conducted by U.S. Bureau of the Census interviewers to obtain basic health and demographic information about the U.S. population. In 2000, a cancer control module was added to the core questionnaire to assess knowledge, attitudes, and practices related to cancer prevention and control. A more detailed description of the Year 2000 survey can be downloaded from the Internet at http://www.cdc.gov/nchs/nhis.htm#2000_NHIS.

A Spanish version of the questionnaire was used if a respondent preferred to complete the interview in Spanish. The Spanish version was developed in several stages. Initial stages included cognitive testing of questionnaires in English and Spanish. Then, a translator experienced in health surveys did a preliminary Spanish translation of the final NHIS questionnaire. Subsequently, NHIS staff convened a translation review conference with bilingual experts from various backgrounds, including senior field interviewers, survey designers, and topic matter experts. The group worked to improve meaning, clarity, and language flow. The revised Spanish instrument was then field tested in both languages; after which, final revisions were made in preparation for the actual survey (37).5 During the survey, interviewers recorded the language of interview (only English, Spanish and English, only Spanish). Respondents who self-identified as Hispanic were asked to report their specific ethnic origin as Puerto Rican, Mexican, Mexican American, Cuban/Cuban American, Dominican, Central or South American, Other Latin American, Other Spanish, or Other.

In the interview, genetic testing was first defined for the respondents as “testing your blood to see if you carry genes which may predict a greater chance of developing cancer at some point in your life. This does not include tests to determine if you have cancer now.” Respondents were then asked: “Have you ever heard of genetic testing to determine if a person is at increased risk of developing cancer?”

Conceptual Model

To formulate study hypotheses and guide the selection of variables for the present analysis, we used a conceptual framework originally developed to identify factors related to awareness of genetic testing in the NHIS survey for all race/ethnic groups combined (33). The framework was adapted from portions of Rogers's Diffusion of Innovations model (38), which describes five stages in the decision process for adoption of technological innovations: knowledge, persuasion, decision, implementation, and confirmation. The earliest form of knowledge, awareness that an innovation exists, is generally associated with demographic factors (e.g., higher education and income) and individual behavioral and need factors. The combined NHIS analysis identified several demographic, cancer history, health care access, health behavior, and health belief factors associated with test awareness including age, race/ethnicity, gender, region of the United States, education, time since last saw a health professional, health insurance status, parents' cancer history, vitamin supplement use, vigorous physical activity, and perceived occurrence of cancer in the family (33). In this study, we hypothesized that after adjustment for these factors, Hispanics may face additional barriers to awareness associated with acculturation.

Data Analysis

The statistical analysis was restricted to Hispanic men and women of ages ≥25 years (n = 4536) because educational level is presumably established for most people by age 25. Each respondent was assigned a basic sampling weight to adjust for the probability of selection in the stratified multistage sampling design. The sampling weight was further adjusted for survey nonresponse and poststratification (39). SUDAAN software (40) was used for the statistical analyses. Weighted percentages and SEs were calculated to estimate the proportion of Hispanics in the major ethnic subgroups (i.e., Mexican American, Mexican, Puerto Rican, Cuban/Cuban American, and Others) who had heard of genetic tests for increased cancer risk in the year 2000. A total of 223 Hispanic respondents were excluded from all analyses due to nonresponse to the NHIS Cancer Control Supplement or to the question about having heard of genetic testing for increased cancer risk. The denominator for these prevalence estimates included everyone with “yes,” “no,” or “don't know” responses to the awareness of genetic testing question (n = 4,313).

Bivariate analysis was conducted to further characterize awareness by demographic, cancer history, health care access, health behavior, health belief, and acculturation factors. The demographic characteristics were Hispanic ethnicity (Mexican, Mexican American, Cuban/Cuban American, Puerto Rican, Other Hispanic), gender, age (25-39, 40-59, 60+ years), region of residence in the United States (Northeast, Midwest, West, South), and education (less than high school, completed high school, 1-4 years college, beyond college). Because family income was missing for approximately one fourth of all NHIS respondents, education was used as the sole indication of socioeconomic status. Cancer history included personal and parents' cancer history (yes, no). Health care factors included: having a usual place to go when sick (yes, no) and health insurance status (private, public, none). Health behaviors and beliefs included vitamin supplement use (yes, no), vigorous physical activity (some, none), perceived cancer risk in self (high, medium, low), and perceived amount of cancer occurrence in the family (high, medium, low).

Finally, the acculturation variables included having been born in the United States (yes, no), language in which interview was conducted (only English, English and Spanish, only Spanish), and level of English language preference. English language preference (low, medium, high) was quantified based on responses to eight questions about language. These questions were phrased in the form “(In) Which language…”: (a) “…do you speak?”; (b) “…did you use as a child?”; (c) “…do you read better?”; (d) “…do you usually speak at home?”; (e) “…do you usually speak with your friends?”; (f) “…do you usually think?”; (g) “…are the T.V. programs you usually watch?”; (h) “…are the radio programs you usually listen to?” Responses were allowed on a Likert (1-5) scale with categories “Only Spanish,” “More Spanish than English,” “Spanish and English about the same,” “More English than Spanish,” and “Only English.” Based on a method used by Berrigan et al. (41), we then classified respondents by language preference tertile. Summed scores of 8 to 13 for the eight questions were classified as low English language preference, scores of 14 to 27 as medium English language preference, and scores of 28 to 40 as high English language preference (Cronbach's α = 0.97).

Weighted backward logistic regression was used to model the multivariate relationship of demographic, cancer history, health care access, health behavior, health belief, and acculturation factors to genetic test awareness. Of the 4,313 respondents in the study, 28 were excluded from the regression analyses because they answered “don't know” to the genetic testing awareness question, and an additional 699 were excluded because they did not respond to other key independent variables. Gender, region of United States, and personal history of cancer were not included in the regression model because they were not significantly (P > 0.05) associated with test awareness in bivariate analysis.

Results

Among the 4,313 NHIS Hispanic respondents of ages ≥25 years, 855 answered “yes” to having heard of genetic tests for increased cancer risk and 3,430 answered “no.” Figure 1 shows the weighted percentage of test awareness for all Hispanic respondents combined, the four largest subgroups (Mexican Americans, Mexicans, Puerto Ricans, and Cuban/Cuban Americans), and all other subgroups (Dominicans, Central or South Americans, Other Latin American, and Other Spanish) that were combined due to insufficient sample size. A total of 20.6% (SE, ±0.8) reported that they had heard of genetic tests for increased cancer risk, with subgroup estimates highest among Puerto Ricans and Mexican Americans, lower among Cuban/Cuban Americans, and lowest among Mexicans.

Figure 1.
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Figure 1.

Weighted percentages (and SEs) of Hispanic respondents in the Year 2000 NHIS who heard of genetic testing for increased cancer risk by ethnicity.

As shown in Table 1 , awareness varied by several acculturation factors. Most notably, 34.8% (±1.8) of respondents who expressed a high level of English language preference had heard of tests, compared with 18.5% (±1.3) with an intermediate level and 9.5% (±1.1) with a low level. Additionally, awareness was almost thrice higher among individuals who completed the NHIS 2000 interview only in English (28.7 ± 1.3%) compared with those who completed it in both Spanish and English (10.3 ± 1.6%) or only in Spanish (10.7 ± 1.1%). Finally, awareness was twice as high among those who were born in the United States (30.4 ± 1.6%) than among those born in another country (15.1 ± 0.9%).

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Table 1.

Weighted percentages and SEs of Hispanic respondents in the year 2000 NHIS who reported having heard of genetic tests for increased cancer risk by population characteristics

Regarding demographic characteristics, awareness decreased substantially with decreasing levels of education, ranging from 45.0 ± 5.1% among people who had greater than a college education to 11.1 ± 1.0% among those with less than high school education. Test awareness was slightly lower among individuals of ages ≥60 years, males, and those living in the South and West. Awareness was higher among people with a personal history of any cancer or at least one parent with a history of any cancer. Furthermore, awareness was highest if the parents had breast, ovarian, or colon cancer (major cancer sites for which genetic testing was available at the time of this survey) compared with other cancers or none at all. Test awareness also varied according to health care use and access factors, with higher awareness observed among people who last saw or talked with a health professional within the past year. Awareness among those with private or military health insurance (27.4 ± 1.2%) was nearly double that of individuals with public (13.3 ± 1.6%) or no health insurance (13.9 ± 1.3%). Awareness was somewhat higher in individuals with health behaviors and beliefs suggestive of general health awareness, including vitamin supplement use, engaging in some vigorous physical activity, and perceiving a high personal risk of cancer or cancer occurrence in the family.

Multivariate Analysis

After adjustment for demographic and other covariates, several language factors were independently associated with genetic test awareness (Table 2 ). Those who expressed an intermediate or low level of English language preference were approximately one third less likely to report test awareness than those who reported a high English language preference. Those who completed the interview in Spanish and English, compared with those completing the interview only in English, were about half as likely to report test awareness. Completion in Spanish only was also inversely associated.

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Table 2.

ORs and 95% CIs of Hispanic respondents who reported having health of genetic tests for increased cancer risks in the year 2000 NHIS

Lower test awareness was associated with decreasing educational level (Wald test for linear trend, P = 0.03). Compared with individuals who had an education beyond college, those who only completed high school [odds ratio (OR), 0.41; 95% confidence interval (95% CI), 0.25-0.67] or did not complete high school (OR, 0.33; 95% CI, 0.20-0.54) were less likely to be aware of genetic testing for cancer risk. In addition, test awareness was inversely associated with not engaging in physical activity, perceiving low or intermediate cancer occurrence in the family (Wald test for linear trend, P = 0.01), and marginally, with having public health insurance or not using vitamin supplements. ORs were suggestive of increasing test awareness with increasing age (Wald test for linear trend, P < 0.01).

Discussion

In the present study, the prevalence of genetic testing awareness was significantly lower among individuals who had intermediate to low English language utilization, after adjustment for key demographic, cancer history, health care access, and health behavior and belief factors. Results were consistent when both language of interview and a scale representing language preferences for activities, such as speaking, reading, and accessing electronic media, were used. In contrast, Hispanic ethnicity and place of origin were not independently associated with test awareness. This indicates that acculturation factors particularly related to language preference and use are important determinants of awareness of genetic testing.

Interestingly, respondents completing the interview in both languages were less likely to be aware of genetic testing than those who completed the interview entirely in Spanish. This may reflect a group of individuals who overestimated their ability to complete the lengthy interview in English, but due to limited language proficiency, reverted back to Spanish when necessary. English proficiency, arguably a factor that facilitates optimal health care system access, is one reason for the differences in knowledge and behavior related to cancer screening use among Hispanics (26, 42, 43).

The findings of our study show that some associations are similar whereas others are different for Hispanics compared with the U.S. population overall, as reported in a previous NHIS study (33). For example, higher education and engaging in routine physical activity were associated with increased awareness of genetic testing in both populations. Having public or no health insurance or not using vitamin supplements, which were inversely associated with genetic testing in the U.S. population (33), were only marginally associated among Hispanics. Older age (60+ years) was a significant predictor of genetic test awareness in the Hispanic sample although the reverse was observed in the U.S. population (33), suggesting an age-ethnicity interaction.

Findings for associations of test awareness with familial factors were also not consistent between Hispanics and the U.S. population. Individuals in the U.S. population who perceived a moderate occurrence of cancer in the family were less aware of tests (33), whereas among Hispanics, the inverse association was observed among those who perceived either a low or moderate occurrence. Cancer history in self or parents was a modest determinant of test awareness in the U.S. population but was not independently associated among Hispanics. Although this may indicate a trend toward risk-appropriate awareness of testing among Hispanics, it is important to consider differential reporting or knowledge of family history (44, 45) as an explanation. For example, in populations with recent migration to the United States, such as certain Hispanic ethnic groups, actual and perceived cancer occurrence in the family may be underestimated due to loss of family health information associated with less frequent personal contact.

Although providing important information related to awareness of cancer genetic testing, the present study has some limitations that must be considered when interpreting results. First, people with higher educational attainment may have overreported awareness due to social desirability (46). Conversely, people with lower educational attainment and general health knowledge may have confused genetic tests with other types of blood tests or cancer screening tests. Additionally, there may be subtle differences in language that may have influenced the Spanish wording of the question on test awareness and that in turn may have affected study participants' responses. Despite extensive efforts to translate survey items into Spanish, this process did not include back translation, which is a common method to establish the validity of materials translated into Spanish (47).

Finally, there is currently controversy about if or how acculturation should be measured in the context of health research (48). Some argue that there has been a lack of underlying conceptualization of the definition of acculturation which precludes accurate measurement of this construct; however, most agree that language use is a central issue in assessing acculturation (48). Two of the three measures of acculturation we used related to language use. Additionally, there is concern that studies which measure acculturation fail to consider other important variables such as Hispanic subethnicity and socioeconomic status (48). In our study, we have attempted to address this issue by simultaneously including these factors in a multivariate model, allowing us to assess their independent effects on awareness. We recognize that other aspects of acculturation such as perceived ethnic identity, residence patterns, and knowledge of country of origin (48), not measured in the present study, may have also influenced awareness of genetic testing for cancer risk.

Conclusion

In a review of genetic counseling issues in the Hispanic community, language was cited as one of the potential barriers to optimal utilization of genetic counseling and testing services (16). Results of this national survey indicate that acculturation factors, particularly those related to language, may affect awareness of cancer genetics services in the Hispanic community. Although genetic tests to predict cancer risk would not be indicated for most individuals in the general Hispanic population, this study strongly suggests that Spanish language translations, and perhaps other cultural factors not addressed here, need to be considered when informing individuals about the role of genetics in cancer risk and providing cancer genetic health services.

Acknowledgments

We thank Timothy McNeel (Information Services, Inc., Silver Spring, MD) for his statistical programming work.

Footnotes

  • ↵5 Deborah Rose, personal communication.

  • Grant support: National Cancer Institute with federal funds.

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted February 16, 2006.
    • Received May 25, 2005.
    • Revision received February 3, 2006.

References

  1. ↵
    Projections of the resident population by age, sex, race, and Hispanic origin: 1999 to 2100. In. Washington, DC; US Census Bureau. Population Projection Program. Population Division (NP-D1-A); 2000.
  2. ↵
    O'Brien K, Cokkinides V, Jemal A, et al. Cancer statistics for Hispanics, 2003. CA Cancer J Clin 2003;53:208–26.
    OpenUrlCrossRefPubMed
  3. American Cancer Society. Cancer facts and figures for Hispanics: 2003-2005. (ACS Publication No. 8623). Atlanta (GA): American Cancer Society; 2003.
  4. ↵
    American Cancer Society. Cancer facts and figures for Hispanics: 2000-2001. (ACS publication no. 8622). Atlanta (GA): American Cancer Society; 2001.
  5. ↵
    Chen WY, Garber JE, Higham S, et al. BRCA1/2 genetic testing in the community setting. J Clin Oncol 2002;20:4485–92.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    Mullineaux LG, Castellano TM, Shaw J, et al. Identification of germline 185delAG BRCA1 mutations in non-Jewish Americans of Spanish ancestry from the San Luis Valley, Colorado. Cancer 2003;98:597–602.
    OpenUrlCrossRefPubMed
  7. Diez O, Osorio A, Robledo M, et al. Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients. Br J Cancer 1999;79:1302–3.
    OpenUrlCrossRefPubMed
  8. Diez O, Cortes J, Domenech M, et al. BRCA1 mutation analysis in 83 Spanish breast and breast/ovarian cancer families. Int J Cancer 1999;83:465–9.
    OpenUrlCrossRefPubMed
  9. Osorio A, Robledo M, Martinez B, et al. Molecular analysis of the BRCA2 gene in 16 breast/ovarian cancer Spanish families. Clin Genet 1998;54:142–7.
    OpenUrlPubMed
  10. Osorio A, Robledo M, Albertos J, et al. Molecular analysis of the six most recurrent mutations in the BRCA1 gene in 87 Spanish breast/ovarian cancer families. Cancer Lett 1998;123:153–8.
    OpenUrlPubMed
  11. de la Hoya M, Sulleiro S, Osorio A, et al. Clustering of cancer-related mutations in a subset of BRCA1 alleles: a study in the Spanish population. Int J Cancer 2002;100:618–9.
    OpenUrlCrossRefPubMed
  12. de la Hoya M, Perez-Segura P, Van Orsouw N, Diaz-Rubio E, Caldes T. Spanish family study on hereditary breast and/or ovarian cancer: analysis of the BRCA1 gene. Int J Cancer 2001;91:137–40.
    OpenUrlCrossRefPubMed
  13. de la Hoya M, Osorio A, Godino J, et al. Association between BRCA1 and BRCA2 mutations and cancer phenotype in Spanish breast/ovarian cancer families: implications for genetic testing. Int J Cancer 2002;97:466–71.
    OpenUrlCrossRefPubMed
  14. ↵
    Weitzel JN, Lagos V, Blazer KR, et al. Prevalence of BRCA mutations and founder effect in high-risk Hispanic families. Cancer Epidemiol Biomarkers Prev 2005;14:1666–71.
    OpenUrlAbstract/FREE Full Text
  15. ↵
    Frank TS, Deffenbaugh AM, Reid JE, et al. Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 2002;20:1480–90.
    OpenUrlAbstract/FREE Full Text
  16. ↵
    Penchaszadeh VB. Genetic counseling issues in Latinos. Genet Test 2001;5:193–200.
    OpenUrlPubMed
  17. Doksum T, Joseph C, Watson M, Kim L, Brand A. Genetics education and underserved populations: summary of the literature. Cambridge (MA): Abt Associates Inc.; 2004.
  18. ↵
    Ramirez AG. Hispanic/Latino Genetics Community Consultation Network (HLGCCN) summitt report 2003. San Antonio (TX): Redes En Accion; 2003. Available from http://www.redesenaccion.org/.
  19. ↵
    Thompson HS, Valdimarsdottir HB, Jandorf L, Redd W. Perceived disadvantages and concerns about abuses of genetic testing for cancer risk: differences across African American, Latina and Caucasian women. Patient Educ Couns 2003;51:217–27.
    OpenUrlCrossRefPubMed
  20. ↵
    Schwartz MD, Benkendorf J, Lerman C, Isaacs C, Ryan-Robertson A, Johnson L. Impact of educational print materials on knowledge, attitudes, and interest in BRCA1/BRCA2: testing among Ashkenazi Jewish women. Cancer 2001;92:932–40.
    OpenUrlCrossRefPubMed
  21. ↵
    Aro AR, Hakonen A, Hietala M, et al. Acceptance of genetic testing in a general population: age, education and gender differences. Patient Educ Couns 1997;32:41–9.
    OpenUrlCrossRefPubMed
  22. Bottorff JL, Ratner PA, Balneaves LG, et al. Women's interest in genetic testing for breast cancer risk: the influence of sociodemographics and knowledge. Cancer Epidemiol Biomarkers Prev 2002;11:89–95.
    OpenUrlAbstract/FREE Full Text
  23. Bosompra K, Ashikaga T, Flynn BS, Worden JK, Solomon LJ. Psychosocial factors associated with the public's willingness to pay for genetic testing for cancer risk: a structural equations model. Health Educ Res 2001;16:157–72.
    OpenUrlAbstract/FREE Full Text
  24. Andrykowski MA, Munn RK, Studts JL. Interest in learning of personal genetic risk for cancer: a general population survey. Prev Med 1996;25:527–36.
    OpenUrlCrossRefPubMed
  25. ↵
    Tambor ES, Rimer BK, Strigo TS. Genetic testing for breast cancer susceptibility: awareness and interest among women in the general population. Am J Med Genet 1997;68:43–9.
    OpenUrlCrossRefPubMed
  26. ↵
    Derose KP, Baker DW. Limited English proficiency and Latinos' use of physician services. Med Care Res Rev 2000;57:76–91.
    OpenUrlAbstract/FREE Full Text
  27. Morales LS, Cunningham WE, Brown JA, Liu H, Hays RD. Are Latinos less satisfied with communication by health care providers? J Gen Intern Med 1999;14:409–17.
    OpenUrlCrossRefPubMed
  28. ↵
    Schur CL, Albers LA. Language, sociodemographics, and health care use of Hispanic adults. J Health Care Poor Underserved 1996;7:140–58.
    OpenUrlPubMed
  29. Fox SA, Stein JA. The effect of physician-patient communication on mammography utilization by different ethnic groups. Med Care 1991;29:1065–82.
    OpenUrlPubMed
  30. Ashton CM, Haidet P, Paterniti DA, et al. Racial and ethnic disparities in the use of health services: bias, preferences, or poor communication? J Gen Intern Med 2003;18:146–52.
    OpenUrlCrossRefPubMed
  31. ↵
    Fiscella K, Franks P, Doescher MP, Saver BG. Disparities in health care by race, ethnicity, and language among the insured: findings from a national sample. Med Care 2002;40:52–9.
    OpenUrlCrossRefPubMed
  32. ↵
    Brodie M, Steffenson A, Valdez J, Levin R, Suro R. 2002 National Survey of Latinos: summary of findings. Menlo Park (CA): The Henry J. Kaiser Family Foundation & Pew Hispanic Center; 2002.
  33. ↵
    Wideroff L, Vadaparampil ST, Breen N, Croyle RT, Freedman AN. Awareness of genetic testing for increased cancer risk in the year 2000 National Health Interview Survey. Community Genet 2003;6:147–56.
    OpenUrlCrossRefPubMed
  34. ↵
    Singer E, Antonucci T, Van Hoewyk J. Racial and ethnic variations in knowledge and attitudes about genetic testing. Genet Test 2004;8:31–43.
    OpenUrlCrossRefPubMed
  35. ↵
    Jacobellis J, Martin L, Engel J, et al. Genetic testing for breast and ovarian cancer susceptibility: evaluating direct-to-consumer marketing-Atlanta, Denver, Raleigh-Durham, and Seattle, 2003. MMWR Morb Mortal Wkly Rep 2004;53:603–6.
    OpenUrlPubMed
  36. ↵
    Myriad. Cancer de seno y de ovario: si tuviera la opcion, se enfrentaria a lo conocido o a lo desconcido (Breast and ovarian cancer: given a choice would you rather deal with the known or the unknown?). In; Myriad Genetics Laboratories, Salt Lake City, (UT); 2002.
  37. ↵
    Rose D. National Center for Health Statistics. Hyatsville (MD); 2003.
  38. ↵
    Rogers EM. Diffusion of innovations. 4th ed. New York (NY): Simon and Schuster, Inc.; 1995. p. 161–203.
  39. ↵
    National Center for Health Statistics. Data File Documentation, National Health Interview Survey 2000 (machine readable data file and documentation). Hyattsville (MD): National Center for Health Statistics; 2002.
  40. ↵
    Shah BV, Barnwell BG, Beiler GS. SUDAAN user's manual, release 7.5. Research Triangle Park (NC): Research Triangle Institute; 1997.
  41. ↵
    Berrigan D, Dodd K, Troiano RP, Reeve B, Ballard-Barbash R. Associations between language acculturation of adult Hispanics in the United States and physical activity. Res Q Exerc Sport. In press.
  42. ↵
    Intercultural Cancer Council. Hispanics/Latinos and Cancer. Houston (TX); Intercultural Cancer Council; 2001.
  43. ↵
    American Cancer Society. Cancer prevention and early detection facts and figures—2002. ACS Publication No. 8600.02. Atlanta (GA): American Cancer Society; 2002.
  44. ↵
    Mitchell RJ, Brewster D, Campbell H, et al. Accuracy of reporting of family history of colorectal cancer. Gut 2004;53:291–5.
    OpenUrlAbstract/FREE Full Text
  45. ↵
    Murff HJ, Byrne D, Syngal S. Cancer risk assessment: quality and impact of the family history interview. Am J Prev Med 2004;27:239–45.
    OpenUrlPubMed
  46. ↵
    Tourangeau R, Rips IJ, Rasinski K. The psychology of survey response. Cambridge: Cambridge University Press; 2000. p. 257–8.
  47. ↵
    Beck CT, Bernal H, Froman RD. Methods to document semantic equivalence of a translated scale. Res Nurs Health 2003;26:64–73.
    OpenUrlCrossRefPubMed
  48. ↵
    Hunt LM, Schneider S, Comer B. Should “acculturation” be a variable in health research? A critical review of research on US Hispanics. Soc Sci Med 2004;59:973–86.
    OpenUrlCrossRefPubMed
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Cancer Epidemiology Biomarkers & Prevention: 15 (4)
April 2006
Volume 15, Issue 4
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The Impact of Acculturation on Awareness of Genetic Testing for Increased Cancer Risk among Hispanics in the Year 2000 National Health Interview Survey
Susan T. Vadaparampil, Louise Wideroff, Nancy Breen and Edward Trapido
Cancer Epidemiol Biomarkers Prev April 1 2006 (15) (4) 618-623; DOI: 10.1158/1055-9965.EPI-05-0378

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The Impact of Acculturation on Awareness of Genetic Testing for Increased Cancer Risk among Hispanics in the Year 2000 National Health Interview Survey
Susan T. Vadaparampil, Louise Wideroff, Nancy Breen and Edward Trapido
Cancer Epidemiol Biomarkers Prev April 1 2006 (15) (4) 618-623; DOI: 10.1158/1055-9965.EPI-05-0378
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