Breast and Ovarian Cancer in Relatives of Cancer Patients, with and without BRCA Mutations

DOI: 10.1158/1055-9965.EPI-05-0687 Published February 2006

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Figure 1.
Distribution of screened non-Hispanic White patients with invasive cancers of the breast or ovary. Breast cancer patients were tested for BRCA1 and BRCA2 mutations; ovarian cancer patients were tested only for BRCA2 mutations.

Table 1.

Distribution of breast and ovarian cancer patients according to age at diagnosis and BRCA mutation status, by cancer site

Table 2.

SIRs for breast cancer in first-degree relatives of cancer patients, by patients' cancer site and BRCA mutation status

Abbreviations: O, number of cancers; E, expected number (based on U.S. incidence rates).
↵* Two-tailed test of similar SIRs in relatives of breast and ovarian cancer patients.
↵† BRCA2 testing was not done among ovarian cancer patients.

Table 3.

SIRs for ovarian cancer in first-degree relatives of cancer patients, by patients' cancer site and BRCA mutation status

↵* Two-tailed test of similar SIRs in relatives of breast and ovarian cancer patients.
↵† BRCA2 testing was not done among ovarian cancer patients.

Table 4.
Distribution of mutation position in patients with BRCA1 mutations, by cancer site
Exon Breast cancer, n (%) Ovarian cancer, n (%)
1-5 7 (39) 12 (41)
6-10 2 (11) 1 (3)
11 5 (28) 12 (41)
12-16 1 (6) 2 (7)
17-24 3 (17) 2 (7)
Total 18 (100) 29 (100)