Article Figures & Data
Tables
- Table 1.
Distribution of select characteristics according to adult BMI among women with invasive breast cancer
Characteristic All (N = 3,924) % Adult BMI (kg/m2) ≤22.99 (n = 2,331), % 23.00-24.99 (n = 666), % 25.00-29.99 (n = 664), % ≥30.00 (n = 263), % Age at diagnosis (y)* 20-39 24.8 27.4 22.4 19.4 20.9 40-45 23.5 24.9 21.9 22.0 19.4 46-49 22.1 22.3 21.6 20.9 24.3 50-55 29.6 25.4 34.1 37.7 35.4 Race* White 87.5 90.6 85.6 82.8 75.3 Black/other 12.5 9.4 14.1 17.2 24.7 Menopausal status* Premenopause 47.0 51.0 43.1 39.9 39.5 Perimenopause 18.0 16.6 19.1 20.3 21.7 Natural menopause 13.1 11.4 15.6 16.0 15.2 Surgical menopause—no ovaries 7.8 7.2 7.5 9.8 8.4 Surgical menopause— ≥1 ovary 14.1 13.8 14.7 14.0 15.2 First-degree family history of breast cancer 11.7 12.2 11.7 10.7 9.5 Frequency of breast examinations† At least once per month 24.5 23.4 26.9 25.2 27.0 Several times a year 26.2 26.4 26.0 25.3 27.4 Once per year or less 49.1 50.1 46.9 49.1 45.6 Previous mammogram 16.1 16.0 17.6 17.3 11.0 Frequency of Pap smears* At least once per year 72.2 75.3 71.9 67.3 57.0 Less than once per year 27.7 24.5 28.1 32.4 42.6 History of benign breast disease‡ 16.1 17.3 16.5 13.6 11.4 Cancer stage at diagnosis* Local 51.4 54.0 47.0 48.2 47.5 Regional 45.4 43.6 49.1 47.7 45.6 Distant 3.2 2.4 3.9 4.1 6.8 Histologic type Ductal 69.6 70.0 67.1 70.6 69.6 Lobular 8.6 9.3 9.5 6.0 7.2 Other 21.8 20.8 23.4 23.4 23.2 Radiation therapy 22.4 23.3 22.8 20.3 19.4 Educational level (y)* <12 12.6 8.6 15.5 19.1 25.1 12-15 63.6 62.5 65.2 64.3 67.7 16+ 23.8 29.0 19.4 16.6 6.8 Number of comorbidities*,§ None 62.8 71.7 60.5 47.9 27.8 1 26.7 22.4 28.2 35.2 39.9 2 8.0 4.6 9.0 13.1 22.4 3+ 2.5 1.4 2.3 3.8 9.9 NOTE: Because of rounding or missing information, some column percentages do not add to 100.
↵* P < 0.001: Pearson χ2 test.
↵† Before being diagnosed with a breast problem (lumps, cysts, or other problem).
↵‡ P < 0.05: Pearson χ2 test.
↵§ Diabetes, high blood pressure, blood clots, kidney disease, gallbladder disease, heart attack, paralysis, rheumatoid arthritis, stroke, other cancer.
- Table 2.
Breast cancer mortality among women with invasive breast cancer by adult BMI
Adult BMI (kg/m2) N No. of deaths HR* (95% CI) ≤ 22.99 2,331 733 1.00 (referent) 23.00-24.99 666 252 1.20 (1.04-1.39) 25.00-29.99 664 253 1.25 (1.08-1.44) ≥30.00 263 109 1.34 (1.09-1.65) P for trend <0.0001 ↵* Adjusted for age at diagnosis, race, radiation therapy, history of benign breast disease, educational level, menopausal status, and cancer stage.
- Table 3.
Breast cancer mortality among women with invasive breast cancer by adult BMI and menopausal status
Premenopause Postmenopause Adult BMI (kg/m2) n No. of deaths HR (95% CI)* n No. of deaths HR* (95% CI) ≤22.99 1,576 501 1.00 (referent) 755 232 1.00 (referent) 23.00-24.99 414 162 1.28 (1.07-1.53) 252 90 1.12 (0.88-1.44) 25.00-29.99 400 153 1.27 (1.05-1.52) 264 100 1.23 (0.97-1.57) ≥30.00 161 65 1.38 (1.05-1.80) 102 44 1.32 (0.94-1.83) P for trend = 0.002 P for trend = 0.1 ↵* Adjusted for age at diagnosis, race, radiation therapy, history of benign breast disease, educational level, and cancer stage.
- Table 4.
Breast cancer mortality among women with invasive breast cancer by BMI at age 18
Age 18 BMI (kg/m2) N No. of deaths HR* (95% CI) ≤ 21.59 2,905 965 1.00 (referent) 21.60-23.79 647 245 1.02 (0.88-1.18) 23.80-25.49 171 62 0.93 (0.71-1.23) ≥25.50 201 75 1.00 (0.77-1.30) P for trend = 0.9 ↵* Adjusted for age at diagnosis, race, radiation therapy, history of benign breast disease, educational level, menopausal status, adult BMI, and cancer stage.
- Table 5.
Breast cancer mortality among women with invasive breast cancer by weight change from age 18 to usual adult weight
Weight change (lbs) N No. of deaths HR* (95% CI) ≤0 809 266 1.00 (referent) 1-10 998 310 0.90 (0.76-1.06) 11-17 589 200 0.98 (0.82-1.18) 18-30 822 301 1.02 (0.86-1.22) ≥31 706 270 1.02 (0.82-1.27) P for trend = 0.5 ↵* Adjusted for age at diagnosis, race, radiation therapy, history of benign breast disease, educational level, menopausal status, adult BMI, and cancer stage.