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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Serum Trans-Fatty Acids Are Associated with Risk of Prostate Cancer in β-Carotene and Retinol Efficacy Trial

Irena B. King, Alan R. Kristal, Steve Schaffer, Mark Thornquist and Gary E. Goodman
Irena B. King
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Alan R. Kristal
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Steve Schaffer
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Mark Thornquist
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Gary E. Goodman
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DOI: 10.1158/1055-9965.EPI-04-0517 Published April 2005
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Abstract

Biomarkers of trans-fatty acid consumption have been associated with increased risks of breast and colon cancer, although no studies have examined their associations with prostate cancer risk. Using data from the β-Carotene and Retinol Efficacy Trial, this nested case-control study examined the relationships between serum phospholipid trans-fatty acids and prostate cancer incidence in 272 case and 426 control men. Trans-fatty acids were measured using organic extraction followed by separations with TLC and gas chromatography. Adjusted odds ratios for risk of prostate cancer with increasing levels of trans-fatty acids were calculated using logistic regression. There were consistent trends for increasing prostate cancer risk with higher levels of C18 but not C16 trans-fatty acids, although only trends for Δ11t 18:1 trans-vaccenic and Δ9c,12t 18:2 fatty acids reached statistical significance. Odds ratios (95% confidence interval) contrasting low versus high quartiles for these fatty acids were 1.69 (1.03-2.77) and 1.79 (1.02-3.15), respectively. There were no consistent differences in associations between low-grade and high-grade cancer among the subset of 209 cases with information on tumor grade. Additional studies are needed to confirm these findings and better control for factors, such as use of prostate-specific antigen screening, which may confound this association.

  • trans-fatty acids
  • prostate cancer
  • inflammation
  • Genitourinary cancers: prostate

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges.This article must therefore be hereby marked advertisement in accordance with 18 U.S.C.Section 1734 solely to indicate this fact.

    • Accepted December 6, 2004.
    • Received July 13, 2004.
    • Revision received November 8, 2004.
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Cancer Epidemiology Biomarkers & Prevention: 14 (4)
April 2005
Volume 14, Issue 4
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Serum Trans-Fatty Acids Are Associated with Risk of Prostate Cancer in β-Carotene and Retinol Efficacy Trial
Irena B. King, Alan R. Kristal, Steve Schaffer, Mark Thornquist and Gary E. Goodman
Cancer Epidemiol Biomarkers Prev April 1 2005 (14) (4) 988-992; DOI: 10.1158/1055-9965.EPI-04-0517

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Serum Trans-Fatty Acids Are Associated with Risk of Prostate Cancer in β-Carotene and Retinol Efficacy Trial
Irena B. King, Alan R. Kristal, Steve Schaffer, Mark Thornquist and Gary E. Goodman
Cancer Epidemiol Biomarkers Prev April 1 2005 (14) (4) 988-992; DOI: 10.1158/1055-9965.EPI-04-0517
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