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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Circulating Levels of Inflammatory Markers and Cancer Risk in the Health Aging and Body Composition Cohort

Dora Il'yasova, Lisa H. Colbert, Tamara B. Harris, Anne B. Newman, Douglas C. Bauer, Suzanne Satterfield and Stephen B. Kritchevsky
Dora Il'yasova
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Lisa H. Colbert
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Tamara B. Harris
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Anne B. Newman
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Douglas C. Bauer
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Suzanne Satterfield
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Stephen B. Kritchevsky
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DOI: 10.1158/1055-9965.EPI-05-0316 Published October 2005
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    Figure 1.

    Dose-response relationships between circulating levels of inflammatory markers and the risk of cancer events: IL-6 (A), CRP (B), and TNF-α (C).

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    Figure 2.

    Time trends in the relationships between circulating levels of inflammatory markers and the risk of cancer events: IL-6 (A), CRP (B), and TNF-α (C). FU, follow-up.

Tables

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  • Table 1.

    Baseline characteristics of the study population

    Noncases 25%-median-75% or % (n = 2,169)Cancer cases 25%-median-75% or % (n = 296)P*
    Follow-up time (mean years)5.922.85
    Age71-73-7671-74-760.09
    Gender (females; %)5538<0.001
    Race (Caucasian; %)†55510.16
    Site (Memphis; %)†50480.49
    Education (%)
        Less than high school27250.30
        High school3331
        Postsecondary4044
    Smoking status (%)
        Never4633<0.001
        Former4452
        Current1016
        Pack-years (continuous)0-2-270-15-43
    Comorbid conditions (%)
        Cardiovascular disease23230.98
        Diabetes16160.91
        Chronic obstructive pulmonary disease and other pulmonary diseases12120.73
    BMI24.1-27.0-30.224.2-27.1-30.7‡0.71
    Abdominal visceral fat area (cm2)93-129-17899-138-183†0.08
    Physical activity, kcal/wk (%)
        0-499.937400.15
        500-999.93435
        ≥1,0002925
    Medication use (%)
        NSAIDs23180.04
        Corticosteroids430.38
        ACE inhibitors15170.43
        Statins12140.34
    • ↵* For continuous variables: P for Wilcoxon rank test (two-group comparison). For categorical variables: P for χ2 test.

    • ↵† Other categories are as follows: race, African American; site, Pittsburgh.

    • ↵‡ Only 185 cases ascertained 2 years after baseline examination (see Materials and Methods).

  • Table 2.

    Distribution of inflammatory markers in the study population

    Inflammatory markerRangeMean (SD)5%25%50%75%95%
    IL-6, pg/mL (n = 2,339)0.21-15.962.42 (1.99)0.721.261.832.826.39
    CRP, mg/L (n = 2,432)0.15-85.183.07 (4.99)0.641.011.693.179.99
    TNF-α, pg/mL (n = 2,298)0.57-29.553.44 (1.70)1.592.143.144.066.21
  • Table 3.

    Association between incident cancer events and inflammatory markers

    Inflammatory markersHR* (95% CI) Number of events
    All cancer events
    Nonfatal cancer events
    Cancer death
    UnadjustedAdjusted†NSAIDs users excluded†Adjusted†Adjusted†NSAIDs users excluded†
    log(IL-6), pg/mL1.18 (0.98-1.41) 2731.13 (0.94-1.37) 2731.10 (0.90-1.35) 2290.95 (0.75-1.19) 1891.63 (1.19-2.23) 841.65 (1.19-2.29) 80
    log(CRP), mg/L1.17 (1.02-1.33) 2911.25 (1.09-1.43) 2911.23 (1.06-1.43) 2431.17 (1.00-1.38) 2011.41 (1.13-1.77) 901.51 (1.19-1.92) 85
    log(TNF-α), pg/mL1.32 (1.00-1.76) 2751.28 (0.96-1.70) 2751.39 (1.02-1.90) 2291.07 (0.76-1.52) 1881.82 (1.14-2.92) 871.95 (1.20-3.15) 82
    • ↵* Log-transformed variables: the HR present the associations with the inflammatory markers related to a unit change on the log scale.

    • ↵† HR adjusted for age, gender, race, and site.

  • Table 4.

    Associations between inflammatory markers and common cancers

    Inflammatory markers*HR*,† (95% CI) Number of events
    BreastColorectalLungProstate
    log(IL-6), pg/mL0.95 (0.54-1.65) 301.44 (0.90-2.31) 401.43 (0.91-2.26) 420.88 (0.59-1.30) 63
    log(CRP), mg/L1.32 (0.91-1.93) 331.44 (1.03-2.02) 411.64 (1.20-2.24) 420.94 (0.70-1.28) 59
    log(TNF-α), pg/mL0.70 (0.29-1.72) 310.90 (0.42-1.94) 391.67 (0.79-3.55) 391.10 (0.61-1.98) 64
    • ↵* Log-transformed variables: the HR present the associations with the inflammatory markers related to a unit change on the log scale.

    • ↵† HR adjusted for age, gender, race, and site.

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Cancer Epidemiology Biomarkers & Prevention: 14 (10)
October 2005
Volume 14, Issue 10
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Circulating Levels of Inflammatory Markers and Cancer Risk in the Health Aging and Body Composition Cohort
Dora Il'yasova, Lisa H. Colbert, Tamara B. Harris, Anne B. Newman, Douglas C. Bauer, Suzanne Satterfield and Stephen B. Kritchevsky
Cancer Epidemiol Biomarkers Prev October 1 2005 (14) (10) 2413-2418; DOI: 10.1158/1055-9965.EPI-05-0316

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Circulating Levels of Inflammatory Markers and Cancer Risk in the Health Aging and Body Composition Cohort
Dora Il'yasova, Lisa H. Colbert, Tamara B. Harris, Anne B. Newman, Douglas C. Bauer, Suzanne Satterfield and Stephen B. Kritchevsky
Cancer Epidemiol Biomarkers Prev October 1 2005 (14) (10) 2413-2418; DOI: 10.1158/1055-9965.EPI-05-0316
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