Article Figures & Data
Tables
- Table 1.
NAT2 allele distribution among controls from case-control studies of breast, prostate, and stomach cancers
Allele Nucleotide substitution(s) Breast, n = 387 [n Alleles (%)] Stomach, n = 414 [n Alleles (%)] Prostate, n = 149 [n Alleles (%)] NAT2*4 None 187 (24.2) 219 (26.4) 64 (21.5) NAT2*5A T341C, C481T 20 (2.6) 7 (0.85) 5 (1.7) NAT2*5B T341C, C481T, A803G 318 (41.1) 309 (37.3) 104 (34.9) NAT2*5C T341C, A803G 17 (2.2) 17 (2.1) 9 (3.0) NAT2*5D T341C — — — NAT2*5E T341C, G590A — — 1 (0.34) NAT2*5F T341C, C481T, C759T, A803G — — — NAT2*6A C282T, G590A 206 (26.6) 251 (30.3) 66 (22.1) NAT2*6B G590A — 1 (0.12) 1 (0.34) NAT2*6C C282T, G590A, A803G — — — NAT2*6D T111C, C282T, G590A — — — NAT2*7A G857A — — — NAT2*7B C282T, G857A 15 (1.9) 19 (2.3) 8 (2.7) NAT2*10 G499A ND ND ND NAT2*11 C481T — — — NAT2*12A A803G 3 (0.4) 4 (0.48) 6 (2.0) NAT2*12B C282T, A803G — — 4 (1.3) NAT2*12C C481T, A803G — — 2 (0.67) NAT2*13 C282T 7 (0.9) 1 (0.12) 14 (4.7) NAT2*14A G191A — — 3 (1.0) NAT2*14B G191A, C282T 1 (0.1) — 11 (3.7) NAT2*14C G191A, T341C, C481T, A803G — — — NAT2*14D G191A, C282T, G590A — — — NAT2*14E G191A, A803G — — — NAT2*14F G191A, T341C, A803G — — — NAT2*14G G191A, C282T, A803G — — — NAT2*17 A434C — — — NAT2*18 A845C — — — NAT2*19 C190T ND ND ND NOTE: Alleles were assigned using a PCR-based assay that detects 11 SNPs and can therefore distinguish among 26 NAT2 allele variants. Alleles in boldface are high-activity (rapid) alleles, whereas all others are low-activity (slow) alleles. “Intermediate” acetylator phenotype is assigned when an individual possesses one “slow” and one “rapid” allele. It should be noted that NAT2*10 phenotype is unknown. ND, Our assay does not detect the G499A or C190T SNPs and thus cannot distinguish these alleles.
- Table 2.
Concordance between two NAT2 genotyping assays among controls from case-control studies of stomach, breast, and prostate cancers
3-SNP assay 11-SNP Assay S I R Total Stomach S 209 0 0 209 I 13 156 0 169 R 1 2 33 36 Total 223 158 33 414 Breast S 204 0 0 204 I 9 142 0 151 R 0 9 23 32 Total 213 151 23 387 Prostate S 62 1 0 63 I 12 50 1 63 R 1 7 15 23 Total 75 58 16 149
September 2004
Volume 13, Issue 9
Volume 13, Issue 9
Impact of Misclassification in Genotype-Exposure Interaction Studies: Example of N-Acetyltransferase 2 (NAT2), Smoking, and Bladder Cancer
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