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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Impact of Misclassification in Genotype-Exposure Interaction Studies: Example of N-Acetyltransferase 2 (NAT2), Smoking, and Bladder Cancer

Anne C. Deitz, Nathanial Rothman, Timothy R. Rebbeck, Richard B. Hayes, Wong-Ho Chow, Wei Zheng, David W. Hein and Montserrat García-Closas
Anne C. Deitz
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Nathanial Rothman
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Timothy R. Rebbeck
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Richard B. Hayes
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Wong-Ho Chow
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Wei Zheng
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David W. Hein
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Montserrat García-Closas
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DOI:  Published September 2004
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Tables

  • Table 1.

    NAT2 allele distribution among controls from case-control studies of breast, prostate, and stomach cancers

    AlleleNucleotide substitution(s)Breast, n = 387 [n Alleles (%)]Stomach, n = 414 [n Alleles (%)]Prostate, n = 149 [n Alleles (%)]
    NAT2*4None187 (24.2)219 (26.4)64 (21.5)
    NAT2*5AT341C, C481T20 (2.6)7 (0.85)5 (1.7)
    NAT2*5BT341C, C481T, A803G318 (41.1)309 (37.3)104 (34.9)
    NAT2*5CT341C, A803G17 (2.2)17 (2.1)9 (3.0)
    NAT2*5DT341C———
    NAT2*5ET341C, G590A——1 (0.34)
    NAT2*5FT341C, C481T, C759T, A803G———
    NAT2*6AC282T, G590A206 (26.6)251 (30.3)66 (22.1)
    NAT2*6BG590A—1 (0.12)1 (0.34)
    NAT2*6CC282T, G590A, A803G———
    NAT2*6DT111C, C282T, G590A———
    NAT2*7AG857A———
    NAT2*7BC282T, G857A15 (1.9)19 (2.3)8 (2.7)
    NAT2*10G499ANDNDND
    NAT2*11C481T———
    NAT2*12AA803G3 (0.4)4 (0.48)6 (2.0)
    NAT2*12BC282T, A803G——4 (1.3)
    NAT2*12CC481T, A803G——2 (0.67)
    NAT2*13C282T7 (0.9)1 (0.12)14 (4.7)
    NAT2*14AG191A——3 (1.0)
    NAT2*14BG191A, C282T1 (0.1)—11 (3.7)
    NAT2*14CG191A, T341C, C481T, A803G———
    NAT2*14DG191A, C282T, G590A———
    NAT2*14EG191A, A803G———
    NAT2*14FG191A, T341C, A803G———
    NAT2*14GG191A, C282T, A803G———
    NAT2*17A434C———
    NAT2*18A845C———
    NAT2*19C190TNDNDND
    • NOTE: Alleles were assigned using a PCR-based assay that detects 11 SNPs and can therefore distinguish among 26 NAT2 allele variants. Alleles in boldface are high-activity (rapid) alleles, whereas all others are low-activity (slow) alleles. “Intermediate” acetylator phenotype is assigned when an individual possesses one “slow” and one “rapid” allele. It should be noted that NAT2*10 phenotype is unknown. ND, Our assay does not detect the G499A or C190T SNPs and thus cannot distinguish these alleles.

  • Table 2.

    Concordance between two NAT2 genotyping assays among controls from case-control studies of stomach, breast, and prostate cancers

    3-SNP assay11-SNP Assay
    SIRTotal
    Stomach
    S20900209
    I131560169
    R123336
    Total22315833414
    Breast
    S20400204
    I91420151
    R092332
    Total21315123387
    Prostate
    S621063
    I1250163
    R171523
    Total755816149
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Cancer Epidemiology Biomarkers & Prevention: 13 (9)
September 2004
Volume 13, Issue 9
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Impact of Misclassification in Genotype-Exposure Interaction Studies: Example of N-Acetyltransferase 2 (NAT2), Smoking, and Bladder Cancer
Anne C. Deitz, Nathanial Rothman, Timothy R. Rebbeck, Richard B. Hayes, Wong-Ho Chow, Wei Zheng, David W. Hein and Montserrat García-Closas
Cancer Epidemiol Biomarkers Prev September 1 2004 (13) (9) 1543-1546;

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Impact of Misclassification in Genotype-Exposure Interaction Studies: Example of N-Acetyltransferase 2 (NAT2), Smoking, and Bladder Cancer
Anne C. Deitz, Nathanial Rothman, Timothy R. Rebbeck, Richard B. Hayes, Wong-Ho Chow, Wei Zheng, David W. Hein and Montserrat García-Closas
Cancer Epidemiol Biomarkers Prev September 1 2004 (13) (9) 1543-1546;
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