Population-Based Prevalence and Age Distribution of Human Papillomavirus Among Women in Santiago, Chile

Catterina Ferreccio; Rodrigo B. Prado; Amaranta V. Luzoro; Sandra Ll. Ampuero; Peter J.F. Snijders; Chris J.L.M. Meijer; Salvatore V. Vaccarella; Alejandro T. Jara; Klaus I. Puschel; Sylvia C. Robles; Rolando Herrero; Silvia F. Franceschi; Jose M. Ojeda

DOI: Published December 2004

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Figure 1.
A. Prevalence of HR HPV by age groups among 955 women (Chile, 2000). Nonparametric regression and 95% CIs. B. Prevalence of LR HPV by age groups among 955 women (Chile, 2000). Nonparametric regression and 95% CIs.

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Table 1.

HPV infections by HPV type, multiplicity of infection, and cytological findings among 955 women (Chile, 2000-2001)

HPV type	Normal cytology					Abnormal cytology
HPV type		Single	Multiple	Total (%)	Single	Multiple	Total (%)	Single	Multiple	Total (%)
HPV−			818			15			833
HPV+	75	28	103 (11.2)	15	4	19 (55.9)	90	32	122 (12.8)
HR HPV+	46	25	71 (7.7)	12	4	16 (47.1)	58	29	87 (9.1)
LR HPV+	29	3	32 (3.5)	3	0	3 (8.8)	32	3	35 (3.7)
HR infections
16	14	6	20 (2.2)	5	0	5 (14.7)	19	6	25 (2.6)
18	4	0	4 (0.4)	0	1	1 (2.9)	4	1	5 (0.5)
31	1	4	5 (0.5)	4*	0	4 (11.8)	5	4	9 (0.9)
33	1	0	1 (0.1)	1	0	1 (2.9)	2	0	2 (0.2)
35	1	2	3 (0.3)	0	0	0	1	2	3 (0.3)
39	2	4	6 (0.7)	0	1	1 (2.9)	2	5	7 (0.7)
45	2	4	6 (0.7)	0	0	0	2	4	6 (0.6)
51	1	5	6 (0.7)	0	0	0	1	5	6 (0.6)
52	4	3	7 (0.8)	0	1	1 (2.9)	4	4	8 (0.8)
56	6	6	12 (1.3)	0	2†	2 (5.9)	6	8	14 (1.5)
58	4	5	9 (1.0)	1	0	1 (2.9)	5	5	10 (1.0)
59	4	4	8 (0.9)	^†	0	1 (2.9)	5	4	9 (0.9)
73	2	0	2 (0.2)	0	0	0	2	0	2 (0.2)
Subtotal	46	43	89	12	5	17	58	48	106
LR infections
6	0	2	2 (0.2)	0	0	0	0	2	2 (0.2)
11	2	2	4 (0.4)	0	0	0	2	2	4 (0.4)
30	0	0	0	0	1†	1 (2.9)	0	1	1 (0.1)
32	0	1	1 (0.1)	0	0	0	0	1	1 (0.1)
40	1	1	2 (0.2)	0	0	0	1	1	2 (0.2)
42	4	3	7 (0.8)	0	0	0	4	3	7 (0.7)
43	1	2	3 (0.3)	0	0	0	1	2	3 (0.3)
53	1	1	2 (0.2)	1	0	1 (2.9)	2	1	3 (0.3)
54	1	0	1 (0.1)	0	0	0	1	0	1 (0.1)
55	1	0	1 (0.1)	0	0	0	1	0	1 (0.1)
64	2	0	2 (0.2)	0	0	0	2	0	2 (0.2)
66	3	1	4 (0.4)	0	1	1 (2.9)	3	2	5 (0.5)
67	2	3	5 (0.5)	1	0	1 (2.9)	3	3	6 (0.6)
70	5	0	5 (0.5)	1	1	2 (5.9)	6	1	7 (0.7)
72	0	1	1 (0.1)	0	0	0	0	1	1 (0.1)
81	3	2	5 (0.5)	0	0	0	3	2	5 (0.5)
83	1	1	2 (0.2)	0	0	0	1	1	2 (0.2)
85	1	0	1 (0.1)	0	0	0	1	0	1 (0.1)
86	1	0	1 (0.1)	0	0	0	1	0	1 (0.1)
CP6108	0	2	2 (0.2)	0	0	0	0	2	2 (0.2)
JC9710	0	1	1 (0.1)	0	0	0	0	1	1 (0.1)
Subtotal	29	23	52	3	3	6	32	26	58
Total	75	66	141	15	8	23	90	74	164

↵* Includes two HSIL or worse.
↵† Includes one HSIL or worse.

Table 2.

OR and 95% CI of HPV infection by selected characteristics among 955 women (Chile, 2000-2001)

Selected characteristics			HPV	HPV	%	OR^* (95% CI)
Selected characteristics				Neg	Pos	Pos
Age (y); χ² per trend, 1.65; P = 0.20	<25^†	104	30	22.4	1
		25-34	163	22	11.9	0.5 (0.3-0.9)
		35-44	197	18	8.4	0.3 (0.2-0.6)
		45-54	151	17	10.1	0.4 (0.2-0.7)
		55-64	137	20	12.7	0.5 (0.3-0.9)
		>65	81	15	15.6	0.6 (0.3-1.3)
Education (years in school); χ² per trend 3.67; P = 0.06	>12^†	178	24	11.9	1
		8-11	306	42	12.1	1.2 (0.7-2.0)
		4-7	216	33	13.3	1.4 (0.8-2.6)
		<3	133	23	14.7	1.6 (0.8-3.4)
Smoking; χ² per trend 7.12; P = 0.01	Never†	378	38	9.1	1
		Former	131	20	13.3	1.5 (0.8-2.6)
		Current
		< 5 cigarette/d	165	35	17.5	2.1 (1.2-3.5)
		≥ 5 cigarette/d	155	29	15.8	2.0 (1.2-3.5)
		Ever	451	84	15.7	1.8 (1.2-2.8)

	Marital status	Married^†	644	78	10.8	1
		Single	73	20	21.5	1.6 (0.9-3.0)
	Separated/divorced/widowed	116	24	17.1	1.8 (1.0-3.3)
Age at first sexual intercourse; χ² per trend: 1.78; P = 0.18	>21^†	190	20	9.5	1
		19-20	135	17	11.2	1.2 (0.6-2.4)
		17-18	252	37	12.8	1.3 (0.7-2.3)
		<17	247	47	16.0	1.5 (0.8-2.7)
No. lifetime sexual partners; χ² per trend: 15.55; P < 0.001	1†	532	57	9.7	1
		2	223	43	16.2	1.8 (1.2-2.8)
		>3	71	21	22.8	2.8 (1.6-5.0)
Husband extramarital sexual relations	No^†	331	45	12.0	1
		Uncertain	92	9	8.9	0.7 (0.3-1.6)
		Yes	403	67	14.3	1.3 (0.9-2.0)
Condom use	Never^†	698	106	13.2	1
Condom use		Ever	127	15	10.6	0.8 (0.4-1.2)
Intrauterine device use	Never^†	232	45	16.3	1
Intrauterine device use		Ever	601	77	11.4	0.8 (0.5-1.2)
Injectable contraceptive use	Never used hormonal contraceptive^†	491	64	11.5	1
Injectable contraceptive use		Ever	48	9	15.8	1.8 (0.8-4.0)
Oral contraceptive use	Never^†	502	69	12.1	1
		Ever	322	52	13.9	1.3 (0.8-1.9)
		Current	81	16	16.5	1.4 (0.7-2.6)
		Former	242	36	13.0	1.2 (0.8-1.9)
Duration oral contraceptives; χ² per trend: 0.02; P = 0.89	<3	140	36	20.5	1.9 (1.2-3.0)
Duration oral contraceptives; χ² per trend: 0.02; P = 0.89		≥3	183	16	8.0	0.7 (0.4-1.3)

NOTE: Some strata do not add up to the total because of missing values.
Abbreviations: neg, negative; pos, positive.
↵* Adjusted by age (P < 0.05, in bold).
↵† Reference category.