Article Figures & Data
Figures
- Fig. 1.
Three-dimensional modeling of breast cancer risk estimates according to CAG repeat polymorphism of AR. “Short” and “long” allele are expressed in absolute number of CAG repeats, and estimated ORs have been calculated relative to women who have a median number of CAGn on each of their alleles (22 and 24, respectively).
Tables
- Table 1
Characteristics of breast cancer cases and controls from breast clinic of PGH, Manila, Philippines
No. (%) of Cases Controls Total (n) 299 229 Ethnicity Malay 220 (74.0) 163 (71.1) Malay-Other (e.g. Malay-Chinese) 61 (20.4) 43 (18.8) Spanish 5 (1.7) 3 (1.3) Chinese 4 (1.3) 3 (1.3) Spanish-Chinese 2 (.7) 1 (.4) Unknown 7 (2.3) 16 (7.0) Age distribution (yrs) 20–34 33 (11.0) 72 (31.4) 35–44 127 (42.5) 86 (37.6) 45–54 118 (39.5) 63 (27.5) 55–70 21 (7.0) 8 (3.5) Tumor histology Infiltrating ductal 257 (86.0) — Infiltrating lobular 2 (.7) Papillary 7 (2.3) Medullary 2 (.7) Other 17 (5.7) Unknown 14 (4.7) Stage I 8 (2.7) — II 94 (31.4) III 153 (51.2) IV 30 (10.0) Unknown 14 (4.7) Estrogen receptora Negative 52 (40.3) — Positive 77 (59.7) -
a Percentages were calculated from cases for whom this information was available.
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- Table 2
AR exon 1 CAGn allele categories and breast cancer risk among 299 cases and 229 controls
CAG repeat cut-off No. of cases No. of controls ORs 95% CI P AR long allele ≤21 16 6 2.1 0.81–5.45 0.13 ≤22 49 35 1.09 0.68–1.74 0.81 ≤23 94 94 0.66 0.46–0.94 0.028 ≤24 139 131 0.65 0.46–0.92 0.018 ≤25 183 169 0.56 0.38–0.82 0.003 ≤26 218 181 0.71 0.48–1.07 0.12 ≤27 254 206 0.63 0.37–1.08 0.12 AR short allele ≤19 46 40 0.86 0.54–1.37 0.55 ≤20 69 54 0.90 0.65–1.46 0.92 ≤21 110 81 1.06 0.74–1.52 0.78 ≤22 178 152 0.74 0.52–1.07 0.12 ≤23 239 194 0.72 0.46–1.14 0.17 ≤24 267 215 0.60 0.28–1.04 0.09 ≤25 284 223 0.51 0.19–1.33 0.18 AR mean of alleles ≤20 28 22 0.97 0.54–1.75 1 ≤21 54 40 1.0 0.66–1.64 0.91 ≤22 91 75 0.90 0.62–1.30 0.57 ≤23 139 129 0.67 0.48–0.95 0.028 ≤24 200 176 0.61 0.41–0.90 0.015 ≤25 242 206 0.47 0.28–0.80 0.005 ≤26 275 220 0.47 0.21–1.03 0.07 ≤27 288 225 0.46 0.15–1.48 0.7 -
The odds ratios presented are those for breast cancer risk for women falling in the category below the cutoff value, compared to women above the cutoff point.
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- Table 3
Association of AR exon 1 CAGn polymorphism with breast cancer
Mean of alleles cut-off Long allele cut-off No. ≤25 No. >25 Crude ORs (95% CI) Adjusteda ORs (95% CI) No. ≤25 No. >25 Crude ORs (95% CI) Adjusteda ORs (95% CI) All women Cases 242 57 0.47 (0.28–0.8) 0.47 (0.24–0.94) 183 116 0.56 (0.39–0.81) 0.43 (0.26–0.71) Controls 206 23 169 60 Age group <50 Cases 197 42 0.56 (0.32–0.98) 0.58 (0.27–1.23) 146 93 0.59 (0.40–0.89) 0.45 (0.26–0.76) Controls 176 21 143 54 50+ Cases 45 15 0.2 (0.04–0.94) 0.2 (0.03–1.15) 37 23 0.37 (0.13–1.04) 0.35 (0.08–1.39) Controls 30 2 26 6 Menopause Premenopausal Cases 181 40 0.44 (0.23–0.82) 0.39 (0.17–0.91) 135 86 0.6 (0.39–0.92) 0.38 (0.21–0.68) Controls 156 15 124 47 Postmenopausal Cases 56 16 0.36 (0.11–1.16) 0.39 (0.08–1.75) 45 27 0.44 (0.18–1.06) 0.43 (0.12–1.56) Controls 39 4 34 9 Family historyb Yes Cases 32 4 — — 25 11 0.67 (0.2–2.27) 0.67 (0.14–3.08) Controls 22 0 17 5 No Cases 192 49 0.38 (0.2–0.7) 0.42 (0.2–0.89) 146 95 0.52 (0.34–0.8) 0.38 (0.22–0.66) Controls 156 15 128 43 -
a Adjusted for age at menarche, age at first birth, age at last birth, oral contraceptive use, and smoking.
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b Family history of breast or ovarian cancer, includes only subjects for whom this information was available.
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- Table 4
Results of multivariate analyses of AR exon 1 CAGn polymorphism and breast cancer
ORsa (95% CI) Adjustedb ORs (95% CI) Total (n) AR long allele ≤23 0.61 (0.42–0.9) 0.47 (0.28–0.77) ≤24 0.62 (0.42–0.9) 0.47 (0.29–0.76) ≤25 0.50 (0.33–0.76) 0.39 (0.23–0.67) AR mean of alleles ≤23 0.64 (0.44–0.93) 0.57 (0.35–0.91) ≤24 0.54 (0.35–0.83) 0.48 (0.28–0.84) ≤25 0.32 (0.17–0.61) 0.34 (0.16–0.74) -
a Adjusted for age group, family history, acne, and menopausal status.
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b Adjusted for age group, family history, acne, menopausal status, age at menarche, parity, age at first birth, age at last birth, oral contraceptive use, and smoking.
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Volume 12, Issue 9
