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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention

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Research Articles

Determinants of Circulating Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations in a Cohort of Singapore Men and Women

Nicole M. Probst-Hensch, Hao Wang, Victor H. H. Goh, Adeline Seow, Hin-Peng Lee and Mimi C. Yu
Nicole M. Probst-Hensch
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Hao Wang
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Victor H. H. Goh
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Adeline Seow
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Hin-Peng Lee
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Mimi C. Yu
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DOI:  Published August 2003
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Abstract

Variation in the circulating concentrations of the insulin-like growth factor (IGF) system has been implicated in the etiology of chronic diseases including cancer (prostate, breast, colon, and lung), heart disease, type 2 diabetes, and osteoporosis. We searched for sociodemographic, anthropometric, reproductive, lifestyle, and dietary determinants of IGF-I and insulin-like growth factor binding protein (IGFBP) -3 serum concentrations. Serum samples were collected in a Singapore Chinese cohort with a mean age of 61 years. Subject information was assessed during an in-person interview. Radioimmunometrically measured IGF-I and IGFBP-3 concentrations were available for 312 men and 326 postmenopausal women ages 50 years or older. Mean IGF-I concentrations were 144 ng/ml and 121 ng/ml for men and women, respectively (gender difference, P < 0.0001), and mean IGFBP-3 concentrations were 3710 ng/ml and 4147 ng/ml for men and women, respectively (gender difference, P < 0.0001). IGF-I and IGFBP-3 decreased with age (P for trend <0.0001); the age-related decrease in the IGF-I:IGFBP-3 molar ratio was stronger in women than men. IGF-I concentrations were higher among physically inactive subjects and among women with an early age at menarche. Consumption of saturated fat was found to decrease, and intake of ω-3 polyunsaturated fatty acids and of dietary fiber was found to increase circulating IGFBP-3 concentrations. Intake of calcium from food and supplement was associated positively with circulating IGF-I, IGFBP-3, and molar ratio. Intake of soy was associated positively with IGF-I and molar ratio concentrations, but only in men. The results of this study lend additional support to the hypothesis that circulating IGF-I concentrations increase the risk of prostate, bladder, colorectal, and breast cancer.

  • Received January 17, 2003.
  • Revision received April 17, 2003.
  • Accepted April 30, 2003.
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Cancer Epidemiology Biomarkers & Prevention: 12 (8)
August 2003
Volume 12, Issue 8
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Determinants of Circulating Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations in a Cohort of Singapore Men and Women
Nicole M. Probst-Hensch, Hao Wang, Victor H. H. Goh, Adeline Seow, Hin-Peng Lee and Mimi C. Yu
Cancer Epidemiol Biomarkers Prev August 1 2003 (12) (8) 739-746;

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Determinants of Circulating Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations in a Cohort of Singapore Men and Women
Nicole M. Probst-Hensch, Hao Wang, Victor H. H. Goh, Adeline Seow, Hin-Peng Lee and Mimi C. Yu
Cancer Epidemiol Biomarkers Prev August 1 2003 (12) (8) 739-746;
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