Null Association between Prostate Cancer and Serum Folate, Vitamin B6, Vitamin B12, and Homocysteine

DOI: Published November 2003

Article Figures & Data

Table 1

Adjusted ORs and 95% CIs of prostate cancer by baseline serum nutrient quartiles (ATBC Study, 1985–1994)

Serum nutrients	Cases (n = 224)^a	Controls (n = 454)	OR^b	95% CI
Folate (nm)
1 (≤6.87)	56	118	1.00
2 (6.88–8.69)	55	109	1.10	0.69–1.75
3 (8.70–10.79)	52	114	1.04	0.64–1.67
4 (>10.79)	61	113	1.20	0.74–1.94
			p trend = 0.52
Vitamin B₆ (nm)
1 (≤19.31)	57	114	1.00
2 (19.32–27.88)	58	113	1.03	0.67–1.60
3 (27.89–41.08)	45	114	0.76	0.46–1.24
4 (>41.08)	64	113	1.11	0.71–1.75
			p trend = 0.64
Vitamin B₁₂ (pm)
1 (≤280.91)	53	114	1.00
2 (280.92–345.57)	61	113	1.19	0.76–1.86
3 (345.58–414.91)	52	114	1.00	0.62–1.60
4 (>414.91)	58	113	1.12	0.70–1.78
			p trend = 0.81
Homocysteine (μm)
1 (≤10.08)	53	114	1.00
2 (10.09–11.79)	51	113	0.94	0.58–1.52
3 (11.80–14.20)	62	115	1.15	0.71–1.86
4 (>14.20)	58	112	1.05	0.64–1.73
			p trend = 0.68

a Eight cases and 10 controls were lost due to cracked vials.
b ORs are adjusted for BPH. Controls were matched to cases on age, clinic, intervention group, and date of baseline blood draw.