Article Figures & Data
Tables
- Table 1
Mean ± SD of baseline characteristics of the 191 study subjects by the VDR FokI genotype
Variable VDR FokI genotype Pa FF Ff ff No. of subjects (%) 78 (41%) 73 (38%) 40 (21%) Age at surgery (yrs) 64.8 ± 6.8 65.2 ± 6.5 63.2 ± 6.2 0.28 % Gleason grade 4/5 42.8 ± 30.0 43.8 ± 30.2 30.3 ± 28.6 0.05b Index cancer volume (cc) 5.2 ± 5.3 5.3 ± 5.7 5.7 ± 6.0 0.88 Preoperative serum PSA (ng/ml) 24.5 ± 39.5 19.7 ± 23.2 18.5 ± 14.1 0.49 -
a By ANOVA.
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b P = 0.015 by t test when the FF and Ff genotypes were combined and compared with the ff genotype.
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- Table 2
Results of Cox proportional hazards model analysis for PSA failure
Covariates adjusted fora VDR FokI genotypeb Ff ff HR 95% CI HR 95% CI Age 1.02 0.66–1.58 0.76 0.44–1.32 Age, Gleason grade, cancer, volume, and preoperative serum PSA 1.07 0.68–1.69 1.03 0.58–1.85 -
a The following categories were used: age at surgery in years (<60, 60–64, 65–69, 70+); % Gleason grade 4/5 (<15%, 15–34%, 35–69%, ≥70%); cancer volume in cc (<2.00, 2.00–3.25, 3.26–6.68, ≥6.69); and preoperative serum PSA level in ng/ml (<9.1, 9.1–14.8, 14.9–24.9, ≥25.0).
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b The FF genotype was considered as a reference category.
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January 2003
Volume 12, Issue 1
Volume 12, Issue 1
Vitamin D Receptor Start Codon Polymorphism (FokI) and Prostate Cancer Progression
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