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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Effects of Oral Administration of N-Acetyl-l-cysteine

A Multi-Biomarker Study in Smokers

Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, Francesco D’Agostini, Alberto Izzotti, Anna Camoirano, Alfons J. M. Balm, Jan Willem Dallinga, Aalt Bast, Guido R. M. M. Haenen, Laura Van’t Veer, Paul Baas, Harumasa Sakai and Nico Van Zandwijk
Frederik Jan Van Schooten
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Ahmad Besarati Nia
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Silvio De Flora
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Francesco D’Agostini
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Alberto Izzotti
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Anna Camoirano
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Alfons J. M. Balm
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Jan Willem Dallinga
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Aalt Bast
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Guido R. M. M. Haenen
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Laura Van’t Veer
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Paul Baas
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Harumasa Sakai
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Nico Van Zandwijk
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DOI:  Published February 2002
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    Fig. 1.

    Flow diagram of the study.

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    Fig. 2.

    Correlation between plasma cotinine levels in the NAC (r = 0.7, P = 0.009) and placebo (r = 0.7, P = 0.005) groups at time 0 (T0) and after 6 months (T1).

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    Fig. 3.

    Dependency of exposure to NAC in modulating BAL cell lipophilic-DNA adducts.

Tables

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  • Table 1

    Characteristics of the study populationa

    NAC groupPlacebo group
    Number2120
    Sex (male/female)6/158/12
    Age42 ± 2.344 ± 1.9
    Cigarettes/day24.8 ± 2.028.5 ± 3.1
    Tar/day (mg)335.0 ± 46.1417.4 ± 56.9
    Nicotine/day (mg)29.3 ± 5.036.9 ± 6.1
    Smoking years25 ± 1.827 ± 1.8
    Pack years31.9 ± 3.739.8 ± 5.8
    • a Results are expressed as mean ± SE.

  • Table 2

    Summary of paired data of the quantified biomarkers in NAC and placebo groups at pre- and postintervention times

    NAC group Mean ± SEPlacebo group Mean ± SE
    nT0T1nT0T1
    Cotinine (plasma) (μg/l)15445 ± 57467 ± 5616510 ± 47469 ± 39
    Cotinine (BAL fluid; μg/l)111788 ± 3153678 ± 1793142527 ± 4801794 ± 291a
    Urine mutagenicity (×1000 revertants)6154 ± 36133 ± 1811153 ± 24121 ± 19
    4-ABP-Hb adducts (ng/g Hb)160.21 ± 0.020.20 ± 0.02160.23 ± 0.020.26 ± 0.02
    Lipophilic-DNA adducts (PBL;/108 nucleotides)151.46 ± 0.12.50 ± 0.5161.46 ± 0.22.52 ± 0.3b
    Lipophilic-DNA adducts (BAL cells; /108 nucleotides)106.01 ± 0.94.25 ± 0.8c106.03 ± 0.75.9 ± 0.7
    8-OH-dG adducts (BAL cells; 105 nucleotides)34.9 ± 0.71.8 ± 0.3d,e34.8 ± 0.53.2 ± 0.8
    PAH-DNA adducts (MFCs; Nucleic stain density)120.04 ± 0.010.06 ± 0.01140.05 ± 0.010.05 ± 0.01
    PAH-DNA adducts (BMCs; Nucleic stain density)90.06 ± 0.010.05 ± 0.01130.06 ± 0.010.07 ± 0.01
    Micronuclei (MFCs; %)151.3 ± 0.30.9 ± 0.3f151.2 ± 0.31.0 ± 0.2
    Micronuclei (SPCs; %)151.3 ± 0.20.9 ± 0.2151.4 ± 0.21.5 ± 0.2
    TEAC (plasma; μm/l)16393 ± 14473 ± 1916387 ± 11450 ± 12g
    TEAC (BAL fluid; μm/l)112043 ± 2541806 ± 271141703 ± 2031777 ± 272
    • a Statistically significant as compared with the placebo group at T0, P = 0.05.

    • b Statistically significant as compared with the placebo group at T0, P = 0.01.

    • c Statistically significant as compared with the NAC group at T0, P = 0.05.

    • d Statistically significant as compared with the placebo group at T1, P = 0.03.

    • e Statistically significant as compared with the NAC group at T0, P = 0.003.

    • f Statistically significant as compared with the NAC group at T0, P = 0.05.

    • g Statistically significant as compared with the placebo group at T0, P = 0.008.

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February 2002
Volume 11, Issue 2
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Effects of Oral Administration of N-Acetyl-l-cysteine
Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, Francesco D’Agostini, Alberto Izzotti, Anna Camoirano, Alfons J. M. Balm, Jan Willem Dallinga, Aalt Bast, Guido R. M. M. Haenen, Laura Van’t Veer, Paul Baas, Harumasa Sakai and Nico Van Zandwijk
Cancer Epidemiol Biomarkers Prev February 1 2002 (11) (2) 167-175;

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Effects of Oral Administration of N-Acetyl-l-cysteine
Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, Francesco D’Agostini, Alberto Izzotti, Anna Camoirano, Alfons J. M. Balm, Jan Willem Dallinga, Aalt Bast, Guido R. M. M. Haenen, Laura Van’t Veer, Paul Baas, Harumasa Sakai and Nico Van Zandwijk
Cancer Epidemiol Biomarkers Prev February 1 2002 (11) (2) 167-175;
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