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Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention
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Ethanol Promotes Intestinal Tumorigenesis in the MIN Mouse

Hemant K. Roy, James M. Gulizia, William J. Karolski, Anne Ratashak, Michael F. Sorrell and Dean Tuma
Hemant K. Roy
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James M. Gulizia
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William J. Karolski
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Anne Ratashak
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Michael F. Sorrell
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Dean Tuma
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DOI:  Published November 2002
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    Fig. 1.

    Dietary ethanol supplementation induced MIN mice tumorigenesis. Ethanol supplementation resulted in a 35% increase in intestinal tumor multiplicity (p = 0.027). The increase in tumor number with ethanol was most dramatic in the distal small bowel, which is where most of the tumors were located in both the control and ethanol groups.

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    Fig. 2.

    MAA adducts were detected in the uninvolved intestinal epithelium of the MIN mouse. These were demonstrated in both the nucleus (arrow) as well as the cytoplasmic localization.

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November 2002
Volume 11, Issue 11
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Ethanol Promotes Intestinal Tumorigenesis in the MIN Mouse
Hemant K. Roy, James M. Gulizia, William J. Karolski, Anne Ratashak, Michael F. Sorrell and Dean Tuma
Cancer Epidemiol Biomarkers Prev November 1 2002 (11) (11) 1499-1502;

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Ethanol Promotes Intestinal Tumorigenesis in the MIN Mouse
Hemant K. Roy, James M. Gulizia, William J. Karolski, Anne Ratashak, Michael F. Sorrell and Dean Tuma
Cancer Epidemiol Biomarkers Prev November 1 2002 (11) (11) 1499-1502;
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