Article Figures & Data
Tables
- Table 1
Adjusteda mean hormone concentrations by CYP17 MspA1 I and SRD5A2 V89L polymorphisms in 622 British men
CYP17 gene SRD5A2 gene A1/A1 n = 266 A1/A2n = 273 A2/A2n = 83 Pb V/Vn = 317 V/Ln = 245 L/Ln = 49 Pb Testosterone (nmol/liter) 20.2 (19.4–21.1) 21.0 (20.1–21.9) 20.6 (19.1–22.2) 0.446 21.2 (20.4–22.0)c 20.2 (19.4–21.1) 18.7 (16.8–20.6)c 0.037 FT (nmol/liter) 0.43 (0.41–0.44) 0.43 (0.42–0.45) 0.42 (0.39–0.44) 0.477 0.44 (0.42–0.45)d 0.43 (0.42–0.45)c 0.37 (0.34–0.40)d,e 0.001 A-diol-g (nmol/liter) 8.90 (8.46–9.36) 8.74 (8.31–9.19) 8.13 (7.36–8.93) 0.256 8.82 (8.41–9.24) 8.74 (8.27–9.21) 7.96 (6.99–9.00) 0.313 SHBG (nmol/liter) 44.3 (42.1–46.7) 46.3 (44.0–48.7) 49.3 (45.0–54.2) 0.128 46.6 (44.5–48.9) 44.3 (42.0–46.7)c 50.7 (45.0–57.1)e 0.093 LH (IU/liter) 5.34 (5.04–5.66) 5.06 (4.79–5.36) 5.50 (4.96–6.10) 0.266 5.39 (5.11–5.68) 5.29 (4.98–5.62) 5.16 (4.51–5.91) 0.809 -
a Values are adjusted for age (in categories of 20–29, 30–39, 40–49, 50–59, 60–69, 70+), time of day at venipuncture (<10, 10–13.29, 13.30+ h), time since last meal at venipuncture (<1.5, 1.5–<3, 3+ h), and time between blood draw and processing (1, 2, 3, 4+ days).
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b P is test for heterogeneity across the mean hormone concentrations in each genotype (see text).
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c Test of heterogeneity between two means; where two superscripts are the same, V/V genotype is different from V/L genotype at P < 0.05.
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d Test of heterogeneity between two means; where two superscripts are the same, V/V genotype is different from L/L genotype at P < 0.05.
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e Test of heterogeneity between two means; where two superscripts are the same, V/L genotype is different from L/L genotype at P < 0.05.
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Volume 10, Issue 3
