Table 3.

Adjusted logistic regression mediation models for healthcare system distrust (independent variable), physician trust (mediator), and adjuvant breast cancer treatment discordance (dependent variable)

Mediation model A: Physician trust (mediator) regressed on healthcare system distrustMediation model B: Discordance (dependent variable) regressed on healthcare system distrustFinal model: Discordance regressed on healthcare system distrust and physician trust
OR (95% CI)POR (95% CI)POR (95% CI)P
Healthcare system distrust
 Tertiles 1 & 2RefRefRef
 Tertile 30.56 (0.46—0.68)<0.0011.23 (1.03–1.47)0.021.22 (1.03–1.46)0.03
Physician Trust
 Tertiles 1 & 2RefRefRef
 Tertile 30.94 (0.77–1.13)0.49
Age (in years)0.98 (0.97–0.99)<0.0011.00 (0.99–1.01)0.561.00 (0.99–1.01)0.60
Race
 WhiteRefRefRef
 Black0.81 (0.66)1.010.060.89 (0.73)1.090.250.89 (0.72)1.090.24
 Other0.64 (0.40)1.010.051.26 (0.84)1.880.261.25 (0.84)1.870.27
Hispanic1.21 (0.85)1.740.290.90 (0.63)1.290.570.90 (0.63)1.300.58
Income
 <$10,000RefRefRef
 $10,001–$30,0001.19 (0.78)1.830.421.31 (0.88)1.940.191.31 (0.88)1.950.19
 $30,001–$70,0001.50 (0.99)2.280.061.60 (1.08)2.370.021.61 (1.08)2.390.02
 >$70,0001.66 (1.06)2.590.031.52 (0.99)2.330.051.53 (1.00)2.340.05
Education
 High school grad or lessRefRefRef
 Some college1.14 (0.90)1.440.271.12 (0.89)1.400.331.12 (0.90)1.400.32
 College grad or more1.01 (0.79)1.290.951.09 (0.86)1.390.461.09 (0.86)1.390.46
Married or coupled0.92 (0.75)1.130.420.78 (0.64)0.940.010.78 (0.64)0.940.01
Not employed for wages1.11 (0.92)1.340.301.12 (0.93)1.350.221.12 (0.93)1.350.22
Insured1.26 (0.82)1.940.290.91 (0.62)1.340.630.91 (0.62)1.340.64
Stage at diagnosis
 Stage IRefRefRef
 Stage II1.13 (0.94)1.350.200.71 (0.60)0.84<0.0010.71 (0.60)0.85<0.001
 Stage III1.32 (0.92)1.900.130.53 (0.36)0.80<0.0010.54 (0.36)0.80<0.001
State
 FloridaRefRefRef
 Pennsylvania0.90 (0.75)1.080.250.78 (0.66)0.930.010.78 (0.66)0.930.01