Table 2.

Relative HRs of death among elderly PDAC patients for metformin and/or statin users versus neither users (N = 12,572)

Conventional Cox modelTime-Varying Cox model
CategoryUnadjusted HR (95% CI)Adjusted HR (95% CI)aUnadjusted HR (95% CI)Adjusted HR (95% CI)a
Neither usersReferentReferentReferentReferent
Metformin users0.93 (0.87–1.00)0.91 (0.85–0.98)1.05 (0.98–1.13)1.01 (0.94–1.09)
Statin users0.93 (0.89–0.97)0.91 (0.88–0.95)0.95 (0.91–0.99)0.94 (0.90–0.98)
Dual users0.87 (0.83–0.92)0.90 (0.86–0.95)0.98 (0.93–1.03)1.00 (0.95–1.05)
  • aAdjusted for tumor characteristics: stage, grade, tumor size, treatment: resection, radiation, chemotherapy, propensity scores, and imbalanced variables after propensity scores adjustment.