Table 1.

Characteristics of women diagnosed with colorectal cancer across tumor composite scores for CTLs and GZMBa

CTL composite tumor score n = 465GZMB composite tumor score n = 458
Participants' characteristics (%)2–3.94–5.15.2–6.2≥6.3Pe22.1–2.9≥3Pe
n = 103n = 139n = 108n = 115n = 196n = 92n = 170
22.2 (%)29.9 (%)23.2 (%)24.7 (%)47.7%24.9%26.5%
Age at CRC diagnosisb
 ≤71 y41.828.132.423.536.731.523.5
 72–77 y32.046.039.838.340.339.138.8
 >77 y26.225.927.838.30.0423.029.437.70.02
BMIb
 <25 kg/m235.936.038.034.841.329.435.9
 25–30 kg/m237.935.331.534.833.743.531.2
 >30 kg/m226.228.830.630.40.9825.027.232.90.12
Smokingc
 Current8.820.310.612.214.413.013.3
 Former18.616.723.123.521.719.619.3
 Never72.663.066.464.40.1263.967.467.50.96
Stage at diagnosisb
In situ or local30.123.042.637.424.535.940.6
 Regional39.844.638.042.645.438.038.8
 Distant22.318.08.33.520.414.14.1
 Unknown7.814.411.116.50.00089.712.016.5<.0001
Grade at diagnosisb
 Well differentiated4.94.311.11.75.17.64.1
 Moderately differentiated61.259.765.754.858.262.062.4
 Poorly differentiated26.233.118.540.931.123.931.8
 Lymphomas/not stated7.82.94.62.60.0035.66.51.80.28
CRC site
 Proximal colon53.951.144.978.350.351.169.2
 Distal colon/rectal46.148.955.121.7<0.000149.748.930.80.0005
Surgeryd
 No29.142.529.643.529.638.044.7
 Yes70.957.670.456.50.0370.462.055.30.01
Chemotherapyd
 No67.079.178.778.173.073.986.5
 Yes33.020.921.321.90.00827.026.113.50.004
Radiationd
 No95.097.796.399.194.898.998.2
 Yes5.02.33.70.90.435.21.11.80.09
  • Abbreviation: CRC, colorectal cancer.

  • aTumor CTL and GZMB composite scores were created as a sum of corresponding epithelial and stromal scores categorized into quartiles for CTL and tertiles for GZMB.

  • bValue at the CRC diagnosis.

  • cValue at baseline (in 1986).

  • dInitial course of therapy.

  • eP values were based on χ2 test.