Table 4.

Head injuries and risk estimates of childhood and adolescent brain tumors

1-year latency perioda2-years latency periodb5-years latency perioda
CasesControlsAdjusted ORc (95% CI)CasesControlsAdjusted ORc (95% CI)CasesControlsAdjusted ORc (95% CI)
Head injury
 Yes1652771.18 (0.90–1.54)1572651.17 (0.89–1.54)1162051.06 (0.79–1.43)
 No1863661 (ref)1943781 (ref)2354381 (ref)
 Missing131313
No. of times
 No head injury1863661 (ref)1943781 (ref)2354381 (ref)
 11011701.17 (0.85–1.60)1061721.20 (0.88–1.64)881471.12 (0.81–1.55)
 247711.35 (0.88–2.07)36611.18 (0.74–1.88)20381.01 (0.55–1.86)
 3 or more17360.97 (0.52–1.80)15320.98 (0.51–1.90)8200.76 (0.33–1.78)
Loss of consciousnessd
 Yes30421.36 (0.82–2.27)25371.28 (0.73–2.21)17261.17 (0.61–2.23)
 No1262291.09 (0.81–1.48)1242231.10 (0.82–1.48)941721.02 (0.74–1.40)
 No head injury1863661 (ref)1943781 (ref)2354381 (ref)
 Missing109109109
Vomitingd
 Yes44781.16 (0.76–1.78)38711.10 (0.70–1.72)22540.82 (0.48–1.41)
 No1181941.20 (0.90–1.62)116901.20 (0.89–1.61)911481.14 (0.83–1.57)
 No head injury1863661 (ref)1943781 (ref)2354381 (ref)
 Missing484848
Headached
 Yes771271.22 (0.85–1.75)661191.14 (0.78–1.66)39790.95 (0.61–1.50)
 No681161.21 (0.83–1.76)671131.22 (0.84–1.77)54931.12 (0.75–1.67)
 No head injury1863661 (ref)1943781 (ref)2354381 (ref)
 Missing213721372137
  • NOTE: Head injuries that occurred during the latency period were not taken into account.

  • aSensitivity analysis.

  • bMain analyses.

  • cConditional logistic regression models adjusted for highest parental education, maternal age, and paternal age.

  • dSymptoms caused by the head injury.