Table 2.

Association between coffee consumption and risk of colorectal cancer, colon cancer, and rectal cancer in all MECC participants and in major ethnic subgroups

CRC (unadjusted)CRC (adjusteda)Colon (adjusteda)Rectal (adjusteda)
NcaseNcontrolOR95% LCL95% UCLPOR95% LCL95% UCLPOR95% LCL95% UCLPOR95% LCL95% UCLP
All coffee
 Total MECC5,1464,0970.730.640.82<0.0010.740.640.86<0.0010.740.630.87<0.0010.780.610.990.04
 Ashkenazi3,2492,4160.750.640.87<0.0010.820.680.980.030.830.691.010.060.810.611.090.17
 Sephardi1,0069760.660.490.870.0040.590.420.830.0030.570.400.820.0020.750.431.320.32
 Arab7644870.660.391.110.120.720.371.400.330.750.371.530.430.590.241.430.24
Decaf coffee
 Total MECC5,1464,0970.700.600.81<0.0010.820.680.990.040.830.671.020.070.860.621.190.36
 Ashkenazi3,2492,4160.690.580.81<0.0010.840.671.040.110.870.691.100.230.800.551.160.23
 Sephardi1,0069760.820.571.200.310.670.421.080.100.600.351.030.060.980.472.040.95
 Arab7644870.360.111.240.110.440.121.590.210.320.061.640.171.170.206.790.74

NOTE: Odds ratios represent the relative odds associated with developing CRC for coffee-drinkers of any amount versus non-drinkers.

Abbreviations: CRC, colorectal cancer; LCL, lower confidence limit; UCL, upper confidence limit.

  • aAdjusted for sex, age, ethnic subgroup (total MECC only), vegetable consumption, sports participation, statin use, daily low-dose aspirin use, smoking status, and family history in a first-degree relative.