Table 5.

Associations between statin use and prostate cancer aggressiveness, stratified by smoking status

n, cases (aggressive)ORa (95% CI)ORb (95% CI)
Never smokers
 Statin nonusers407 (69)1.00 (ref)1.00 (ref)
 Statin users243 (24)0.43 (0.26–0.72)0.42 (0.25–0.72)
Former smokers
 Statin nonusers585 (109)1.00 (ref)1.00 (ref)
 Statin users407 (67)0.78 (0.56–1.10)0.84 (0.59–1.19)
Current smokers
 Statin nonusers213 (55)1.00 (ref)1.00 (ref)
 Statin users75 (20)1.04 (0.57–1.90)1.36 (0.70–2.64)
  • aAdjusted for age only.

  • bAdjusted for age, race, site, BMI, cholesterol intake, percent saturated fat intake, and prostate cancer screening frequency.