Table 3.

Relative hazard of death for statin use after cancer diagnosis versus never use by different modeling approaches

ModelAdjusted HR (95% CI)P
Model 1: Unadjusted model using statin as a non–time-dependent variable0.84 (0.70–1.00)0.047
Model 2: Unadjusted model using statin as a time-dependent variable (removes immortal time bias)0.97 (0.82–1.16)0.77
Model 3: Multivariable model using statin as a time-dependent variable adjusted for all variables in Table 20.94 (0.78–1.14)0.54
Model 4: Multivariable model using statin as a time-dependent variable that lags by 2 months (removes reverse causation, restricts population to >2 month survivors, n = 958)0.98 (0.80–1.20)0.82

Abbreviations: CI, confidence interval; HR, hazard ratio for statin use.