Model | Adjusted HR (95% CI) | P |
---|---|---|

Model 1: Unadjusted model using statin as a non–time-dependent variable | 0.84 (0.70–1.00) | 0.047 |

Model 2: Unadjusted model using statin as a time-dependent variable (removes immortal time bias) | 0.97 (0.82–1.16) | 0.77 |

Model 3: Multivariable model using statin as a time-dependent variable adjusted for all variables in Table 2 | 0.94 (0.78–1.14) | 0.54 |

Model 4: Multivariable model using statin as a time-dependent variable that lags by 2 months (removes reverse causation, restricts population to >2 month survivors, n = 958) | 0.98 (0.80–1.20) | 0.82 |

Abbreviations: CI, confidence interval; HR, hazard ratio for statin use.