Table 3.

Association of lead SNPs identified in women of European and non-European descent with breast cancer risk among women of Asian (6,269 cases and 6,624 controls) and African ancestry (1,116 cases and 932 controls)

Top SNPsAllelesbSingle marker analysis (Asian)Single marker analysis (African)
RAFLD (r2)cOR (95% CI)dPtrenddRAFLD (r2)cOR (95% CI)dPtrendd
Identified in women of European descent
 Signal 1rs9790517aT/C0.601.00 (0.95–1.06)0.930.061.21 (0.88–1.55)0.28
 Signal 2rs77928427A/C0.060.011.02 (0.91–1.12)0.500.1601.03 (0.85–1.22)0.86
Identified in women of non-European descent
rs1116764G/A0.660.131.10 (1.04–1.16)4.21 × 10−40.8901.02 (0.81–1.23)0.98
rs79219151C/TNA0.9501.63 (1.13–2.13)7.44 × 10–3
rs112095278C/TNA0.9501.65 (1.16–2.14)4.13 × 10−3
rs144956461A/TNA0.9301.56 (1.12–2.01)6.73 × 10−3

Abbreviation: RAF, risk allele frequency.

  • aIndex SNP

  • bRisk/reference allele; risk alleles are shown in bold.

  • cr2 for LD with the index SNP rs9790517 in Asians and Africans, respectively.

  • dAdjusted for age, study, and the first six PC and an additional PC for LMBC study.