Table 2.

GSEA results for 14 serous EOC risk locus TF-centric gene coexpression networksa

Serous EOC risk locusNetwork hub TF geneCoexpression network sizeNormalized enrichmentNominal PFDR q valueTop 5% fold enrichment
17q21.32HOXB2171.642.0E−05b4.0E−05b8.00
17q21.32HOXB7311.620b5.0E−05b4.50
17q21.32HOXB6331.435.0E−043.0E−034.50
2q31HOXD3521.395.0E−044.9E−033.67
17q21.32HOXB5301.374.0E−035.1E−033.00
2q31HOXD1691.258.1E−030.041.50
17q21.32SP21341.187.7E−030.091.57
17q21.32HOXB31031.180.020.082.17
17q21.32TBX21461.100.190.221.33
17q21.32NFE2L13151.060.120.351.06
19p13NR2F63121.040.230.431.50
8q24MYC1301.020.370.450.71
3q25SHOX23681.000.530.560.95
2q31HOXD10851.000.520.520.80
  • aHub-and-spoke networks containing 15 to 500 genes constructed from serous EOC TCGA data.

  • bFor 50,000 permutations, because nominal P = 0 at the default number of 10,000 permutations.