Table 5.

Colorectal cancer by duration and time since last OC among 88,691 NHSI participants

N cases
HR (95% CI)aPtrend
Time since last OC use (years)
Duration of OC use (years)Never≤4>4 to <10≥10 to <1515+
Never1,122
ref
≤19277089
1.79 (0.92–3.47)1.40 (0.95–2.06)1.24 (0.97–1.59)0.91 (0.73–1.13)0.91
>1 to <24112824
1.35 (0.50–3.62)0.97 (0.53–1.77)1.06 (0.72–1.56)1.20 (0.79–1.80)0.87
≥2 to <58327834
1.00 (0.50–2.03)0.85 (0.59–1.22)0.97 (0.77–1.23)1.02 (0.72–1.44)0.88
≥5 to <101772596
0.98 (0.60–1.59)0.95 (0.74–1.21)1.05 (0.81–1.37)1.08 (0.48–2.41)0.91
10+293861
1.20 (0.82–1.74)0.88 (0.63–1.21)0.83 (0.37–1.86)4.61 (0.63–33.71)0.92
Ptrend0.670.670.680.70
  • aAdjusted for age, BMI, height, physical activity, smoking, processed and red meat, folate, calcium, total energy, aspirin use, alcohol, age at first birth, parity, HT use, family history, and previous endoscopy screening.