Table 3.

ORs for prostate cancer by percentile of the PRS and family history

PercentilesORa,bORa,c
PRS group
 <1%1 (baseline)0.14 (0.08–0.24)
 1%–10%2.98 (1.66–5.35)0.41 (0.36–0.47)
 10%–25%4.59 (2.58–8.17)0.63 (0.57–0.70)
 25%–75%7.23 (4.08–12.80)1 (baseline)
 75%–90%12.13 (6.83–21.54)1.68 (1.54–1.83)
 90%–99%16.70 (9.38–29.72)2.31 (2.09–2.56)
 ≥99%30.63 (16.36–57.34)4.24 (3.24–5.53)
Family history2.52 (2.29–2.78)2.52 (2.29–2.78)
  • aORs obtained by fitting PRS group, family history, and age at diagnosis jointly.

  • bORs compared with men in the 1st percentile as baseline.

  • cORs compared with men in the 25th–75th percentile as baseline.