Table 2.

Colorectal cancer subsites in ever and never OC users among 88,691 NHSI and 93,080 NHSII participants

CasesHR (95% CI)
Age-adjustedMultivariablea
Never-usersEver-usersNever-usersEver-usersEver-users
NHSI
Colorectal1,079685ref.0.97 (0.87–1.08)1.01 (0.91–1.12)
 Colon844541ref.1.01 (0.89–1.13)1.04 (0.93–1.18)
  Proximal colon493330ref.1.10 (0.94–1.27)1.14 (0.98–1.32)
  Distal colon326195ref.0.88 (0.72–1.07)0.91 (0.75–1.11)
 Rectum235144ref.0.85 (0.68–1.06)0.89 (0.71–1.12)
NHSII
Colorectal29177ref.0.98 (0.66–1.46)1.03 (0.69–1.53)
 Colon21118ref.0.88 (0.55–1.39)0.91 (0.57–1.46)
  Proximal colon1454ref.0.60 (0.33–1.09)0.63 (0.35–1.15)
  Distal colon762ref.1.37 (0.62–2.99)1.44 (0.66–3.16)
 Rectum859ref.1.27 (0.61–2.66)1.35 (0.64–2.85)
  • aAdjusted for age, BMI, height, physical activity, smoking, processed and red meat, folate, calcium, total energy, aspirin use, alcohol, age at first birth, parity, HT use, family history, and previous endoscopy screening.